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The Role of the Kidneys in Hypertension
Gespeichert in:
Zeitschriftentitel: | The Journal of Clinical Hypertension |
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Personen und Körperschaften: | |
In: | The Journal of Clinical Hypertension, 7, 2005, 9, S. 542-549 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Navar, L. Gabriel Navar, L. Gabriel |
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author |
Navar, L. Gabriel |
spellingShingle |
Navar, L. Gabriel The Journal of Clinical Hypertension The Role of the Kidneys in Hypertension Cardiology and Cardiovascular Medicine Endocrinology, Diabetes and Metabolism Internal Medicine |
author_sort |
navar, l. gabriel |
spelling |
Navar, L. Gabriel 1524-6175 1751-7176 Wiley Cardiology and Cardiovascular Medicine Endocrinology, Diabetes and Metabolism Internal Medicine http://dx.doi.org/10.1111/j.1524-6175.2005.04130.x <jats:p> <jats:italic>The devastating long‐term consequences of high blood pressure include stroke, heart disease, atherosclerosis, renal disease, and other end‐organ damage. From a physiologic perspective, it is not apparent why the propensity for hypertension is so widespread in the general population. Clearly, an adequate arterial pressure is essential for perfusion of the tissues to provide adequate oxygenation and nutrition to the brain and other critical organs. Although the various microcirculatory beds have the capability to adjust vascular resistance to autoregulate blood flow, systemic arterial pressure is usually maintained at levels greater than required for requisite tissue perfusion. The myriad of neurohumoral mechanisms designed to protect against decreases in systemic arterial pressure provide a reserve capacity for increased perfusion when there are increased tissue demands. The unfortunate consequence of having these powerful physiologic control mechanisms is that they may be inappropriately activated in certain circumstances or by genetically determined traits, leading to hypertension and cardiovascular injury. Evidence continues to accumulate indicating that the kidney not only is victim to hypertension‐related injury, but also contributes as a villain to the hypertensinogenic process.</jats:italic> </jats:p> The Role of the Kidneys in Hypertension The Journal of Clinical Hypertension |
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The Role of the Kidneys in Hypertension |
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The Role of the Kidneys in Hypertension |
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The Role of the Kidneys in Hypertension |
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The Role of the Kidneys in Hypertension |
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The Role of the Kidneys in Hypertension |
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the role of the kidneys in hypertension |
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Cardiology and Cardiovascular Medicine Endocrinology, Diabetes and Metabolism Internal Medicine |
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http://dx.doi.org/10.1111/j.1524-6175.2005.04130.x |
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2005 |
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<jats:p> <jats:italic>The devastating long‐term consequences of high blood pressure include stroke, heart disease, atherosclerosis, renal disease, and other end‐organ damage. From a physiologic perspective, it is not apparent why the propensity for hypertension is so widespread in the general population. Clearly, an adequate arterial pressure is essential for perfusion of the tissues to provide adequate oxygenation and nutrition to the brain and other critical organs. Although the various microcirculatory beds have the capability to adjust vascular resistance to autoregulate blood flow, systemic arterial pressure is usually maintained at levels greater than required for requisite tissue perfusion. The myriad of neurohumoral mechanisms designed to protect against decreases in systemic arterial pressure provide a reserve capacity for increased perfusion when there are increased tissue demands. The unfortunate consequence of having these powerful physiologic control mechanisms is that they may be inappropriately activated in certain circumstances or by genetically determined traits, leading to hypertension and cardiovascular injury. Evidence continues to accumulate indicating that the kidney not only is victim to hypertension‐related injury, but also contributes as a villain to the hypertensinogenic process.</jats:italic> </jats:p> |
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author | Navar, L. Gabriel |
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description | <jats:p> <jats:italic>The devastating long‐term consequences of high blood pressure include stroke, heart disease, atherosclerosis, renal disease, and other end‐organ damage. From a physiologic perspective, it is not apparent why the propensity for hypertension is so widespread in the general population. Clearly, an adequate arterial pressure is essential for perfusion of the tissues to provide adequate oxygenation and nutrition to the brain and other critical organs. Although the various microcirculatory beds have the capability to adjust vascular resistance to autoregulate blood flow, systemic arterial pressure is usually maintained at levels greater than required for requisite tissue perfusion. The myriad of neurohumoral mechanisms designed to protect against decreases in systemic arterial pressure provide a reserve capacity for increased perfusion when there are increased tissue demands. The unfortunate consequence of having these powerful physiologic control mechanisms is that they may be inappropriately activated in certain circumstances or by genetically determined traits, leading to hypertension and cardiovascular injury. Evidence continues to accumulate indicating that the kidney not only is victim to hypertension‐related injury, but also contributes as a villain to the hypertensinogenic process.</jats:italic> </jats:p> |
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spelling | Navar, L. Gabriel 1524-6175 1751-7176 Wiley Cardiology and Cardiovascular Medicine Endocrinology, Diabetes and Metabolism Internal Medicine http://dx.doi.org/10.1111/j.1524-6175.2005.04130.x <jats:p> <jats:italic>The devastating long‐term consequences of high blood pressure include stroke, heart disease, atherosclerosis, renal disease, and other end‐organ damage. From a physiologic perspective, it is not apparent why the propensity for hypertension is so widespread in the general population. Clearly, an adequate arterial pressure is essential for perfusion of the tissues to provide adequate oxygenation and nutrition to the brain and other critical organs. Although the various microcirculatory beds have the capability to adjust vascular resistance to autoregulate blood flow, systemic arterial pressure is usually maintained at levels greater than required for requisite tissue perfusion. The myriad of neurohumoral mechanisms designed to protect against decreases in systemic arterial pressure provide a reserve capacity for increased perfusion when there are increased tissue demands. The unfortunate consequence of having these powerful physiologic control mechanisms is that they may be inappropriately activated in certain circumstances or by genetically determined traits, leading to hypertension and cardiovascular injury. Evidence continues to accumulate indicating that the kidney not only is victim to hypertension‐related injury, but also contributes as a villain to the hypertensinogenic process.</jats:italic> </jats:p> The Role of the Kidneys in Hypertension The Journal of Clinical Hypertension |
spellingShingle | Navar, L. Gabriel, The Journal of Clinical Hypertension, The Role of the Kidneys in Hypertension, Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine |
title | The Role of the Kidneys in Hypertension |
title_full | The Role of the Kidneys in Hypertension |
title_fullStr | The Role of the Kidneys in Hypertension |
title_full_unstemmed | The Role of the Kidneys in Hypertension |
title_short | The Role of the Kidneys in Hypertension |
title_sort | the role of the kidneys in hypertension |
title_unstemmed | The Role of the Kidneys in Hypertension |
topic | Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine |
url | http://dx.doi.org/10.1111/j.1524-6175.2005.04130.x |