Eintrag weiter verarbeiten
What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype?
Gespeichert in:
| Zeitschriftentitel: | British Journal of Pharmacology |
|---|---|
| Personen und Körperschaften: | |
| In: | British Journal of Pharmacology, 165, 2012, 5, S. 1223-1225 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Ventura, S Ventura, S |
|---|---|
| author |
Ventura, S |
| spellingShingle |
Ventura, S British Journal of Pharmacology What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? Pharmacology |
| author_sort |
ventura, s |
| spelling |
Ventura, S 0007-1188 1476-5381 Wiley Pharmacology http://dx.doi.org/10.1111/j.1476-5381.2011.01663.x <jats:p>The α<jats:sub>1A</jats:sub>‐adrenoceptor is therapeutically exploited because of its prevalence in the lower urinary tract. The pharmacology shown by this lower urinary tract α<jats:sub>1A</jats:sub>‐adrenoceptor is different from that shown by other α<jats:sub>1A</jats:sub>‐adrenoceptors, which has led to it being subclassified as an α<jats:sub>1L</jats:sub>‐adrenoceptor. Only in the last few years was it shown that this pharmacologically distinct α<jats:sub>1L</jats:sub>‐adrenoceptor is a product of the α<jats:sub>1A</jats:sub>‐adrenoceptor gene. In this issue of the <jats:italic>BJP</jats:italic>, Nishimune <jats:italic>et al</jats:italic>. review the literature on α<jats:sub>1L</jats:sub>‐adrenoceptor pharmacology and discuss the possible molecular mechanisms by which the α<jats:sub>1A</jats:sub>‐adrenoceptor gene is able to produce two pharmacologically distinct adrenoceptor subtypes. Based primarily from their own research using cell lines transfected with α<jats:sub>1A</jats:sub>‐adrenoceptors, they conclude that a protein that interacts with the receptor is the most plausible explanation. The challenge remains to identify any such interacting protein and show how it is able to change the pharmacology of the receptor for different ligands.</jats:p><jats:p><jats:bold>LINKED ARTICLE</jats:bold> This article is a commentary on Nishimune <jats:italic>et al</jats:italic>., pp. 1226–1234 of this issue. To view this paper visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://dx.doi.org/10.1111/j.1476-5381.2011.01591.x">http://dx.doi.org/10.1111/j.1476‐5381.2011.01591.x</jats:ext-link></jats:p> What makes the α<sub>1A</sub>‐adrenoceptor gene express the α<sub>1L</sub>‐adrenoceptor functional phenotype? British Journal of Pharmacology |
| doi_str_mv |
10.1111/j.1476-5381.2011.01663.x |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE0NzYtNTM4MS4yMDExLjAxNjYzLng |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE0NzYtNTM4MS4yMDExLjAxNjYzLng |
| institution |
DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 |
| imprint |
Wiley, 2012 |
| imprint_str_mv |
Wiley, 2012 |
| issn |
1476-5381 0007-1188 |
| issn_str_mv |
1476-5381 0007-1188 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
ventura2012whatmakesthea1aadrenoceptorgeneexpressthea1ladrenoceptorfunctionalphenotype |
| publishDateSort |
2012 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
British Journal of Pharmacology |
| source_id |
49 |
| title |
What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_unstemmed |
What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_full |
What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_fullStr |
What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_full_unstemmed |
What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_short |
What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_sort |
what makes the α<sub>1a</sub>‐adrenoceptor gene express the α<sub>1l</sub>‐adrenoceptor functional phenotype? |
| topic |
Pharmacology |
| url |
http://dx.doi.org/10.1111/j.1476-5381.2011.01663.x |
| publishDate |
2012 |
| physical |
1223-1225 |
| description |
<jats:p>The α<jats:sub>1A</jats:sub>‐adrenoceptor is therapeutically exploited because of its prevalence in the lower urinary tract. The pharmacology shown by this lower urinary tract α<jats:sub>1A</jats:sub>‐adrenoceptor is different from that shown by other α<jats:sub>1A</jats:sub>‐adrenoceptors, which has led to it being subclassified as an α<jats:sub>1L</jats:sub>‐adrenoceptor. Only in the last few years was it shown that this pharmacologically distinct α<jats:sub>1L</jats:sub>‐adrenoceptor is a product of the α<jats:sub>1A</jats:sub>‐adrenoceptor gene. In this issue of the <jats:italic>BJP</jats:italic>, Nishimune <jats:italic>et al</jats:italic>. review the literature on α<jats:sub>1L</jats:sub>‐adrenoceptor pharmacology and discuss the possible molecular mechanisms by which the α<jats:sub>1A</jats:sub>‐adrenoceptor gene is able to produce two pharmacologically distinct adrenoceptor subtypes. Based primarily from their own research using cell lines transfected with α<jats:sub>1A</jats:sub>‐adrenoceptors, they conclude that a protein that interacts with the receptor is the most plausible explanation. The challenge remains to identify any such interacting protein and show how it is able to change the pharmacology of the receptor for different ligands.</jats:p><jats:p><jats:bold>LINKED ARTICLE</jats:bold> This article is a commentary on Nishimune <jats:italic>et al</jats:italic>., pp. 1226–1234 of this issue. To view this paper visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://dx.doi.org/10.1111/j.1476-5381.2011.01591.x">http://dx.doi.org/10.1111/j.1476‐5381.2011.01591.x</jats:ext-link></jats:p> |
| container_issue |
5 |
| container_start_page |
1223 |
| container_title |
British Journal of Pharmacology |
| container_volume |
165 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336041982558219 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:54:08.186Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=What+makes+the+%CE%B11A%E2%80%90adrenoceptor+gene+express+the+%CE%B11L%E2%80%90adrenoceptor+functional+phenotype%3F&rft.date=2012-03-01&genre=article&issn=1476-5381&volume=165&issue=5&spage=1223&epage=1225&pages=1223-1225&jtitle=British+Journal+of+Pharmacology&atitle=What+makes+the+%CE%B1%3Csub%3E1A%3C%2Fsub%3E%E2%80%90adrenoceptor+gene+express+the+%CE%B1%3Csub%3E1L%3C%2Fsub%3E%E2%80%90adrenoceptor+functional+phenotype%3F&aulast=Ventura&aufirst=S&rft_id=info%3Adoi%2F10.1111%2Fj.1476-5381.2011.01663.x&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336041982558219 |
| author | Ventura, S |
| author_facet | Ventura, S, Ventura, S |
| author_sort | ventura, s |
| container_issue | 5 |
| container_start_page | 1223 |
| container_title | British Journal of Pharmacology |
| container_volume | 165 |
| description | <jats:p>The α<jats:sub>1A</jats:sub>‐adrenoceptor is therapeutically exploited because of its prevalence in the lower urinary tract. The pharmacology shown by this lower urinary tract α<jats:sub>1A</jats:sub>‐adrenoceptor is different from that shown by other α<jats:sub>1A</jats:sub>‐adrenoceptors, which has led to it being subclassified as an α<jats:sub>1L</jats:sub>‐adrenoceptor. Only in the last few years was it shown that this pharmacologically distinct α<jats:sub>1L</jats:sub>‐adrenoceptor is a product of the α<jats:sub>1A</jats:sub>‐adrenoceptor gene. In this issue of the <jats:italic>BJP</jats:italic>, Nishimune <jats:italic>et al</jats:italic>. review the literature on α<jats:sub>1L</jats:sub>‐adrenoceptor pharmacology and discuss the possible molecular mechanisms by which the α<jats:sub>1A</jats:sub>‐adrenoceptor gene is able to produce two pharmacologically distinct adrenoceptor subtypes. Based primarily from their own research using cell lines transfected with α<jats:sub>1A</jats:sub>‐adrenoceptors, they conclude that a protein that interacts with the receptor is the most plausible explanation. The challenge remains to identify any such interacting protein and show how it is able to change the pharmacology of the receptor for different ligands.</jats:p><jats:p><jats:bold>LINKED ARTICLE</jats:bold> This article is a commentary on Nishimune <jats:italic>et al</jats:italic>., pp. 1226–1234 of this issue. To view this paper visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://dx.doi.org/10.1111/j.1476-5381.2011.01591.x">http://dx.doi.org/10.1111/j.1476‐5381.2011.01591.x</jats:ext-link></jats:p> |
| doi_str_mv | 10.1111/j.1476-5381.2011.01663.x |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE0NzYtNTM4MS4yMDExLjAxNjYzLng |
| imprint | Wiley, 2012 |
| imprint_str_mv | Wiley, 2012 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
| issn | 1476-5381, 0007-1188 |
| issn_str_mv | 1476-5381, 0007-1188 |
| language | English |
| last_indexed | 2024-03-01T14:54:08.186Z |
| match_str | ventura2012whatmakesthea1aadrenoceptorgeneexpressthea1ladrenoceptorfunctionalphenotype |
| mega_collection | Wiley (CrossRef) |
| physical | 1223-1225 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | British Journal of Pharmacology |
| source_id | 49 |
| spelling | Ventura, S 0007-1188 1476-5381 Wiley Pharmacology http://dx.doi.org/10.1111/j.1476-5381.2011.01663.x <jats:p>The α<jats:sub>1A</jats:sub>‐adrenoceptor is therapeutically exploited because of its prevalence in the lower urinary tract. The pharmacology shown by this lower urinary tract α<jats:sub>1A</jats:sub>‐adrenoceptor is different from that shown by other α<jats:sub>1A</jats:sub>‐adrenoceptors, which has led to it being subclassified as an α<jats:sub>1L</jats:sub>‐adrenoceptor. Only in the last few years was it shown that this pharmacologically distinct α<jats:sub>1L</jats:sub>‐adrenoceptor is a product of the α<jats:sub>1A</jats:sub>‐adrenoceptor gene. In this issue of the <jats:italic>BJP</jats:italic>, Nishimune <jats:italic>et al</jats:italic>. review the literature on α<jats:sub>1L</jats:sub>‐adrenoceptor pharmacology and discuss the possible molecular mechanisms by which the α<jats:sub>1A</jats:sub>‐adrenoceptor gene is able to produce two pharmacologically distinct adrenoceptor subtypes. Based primarily from their own research using cell lines transfected with α<jats:sub>1A</jats:sub>‐adrenoceptors, they conclude that a protein that interacts with the receptor is the most plausible explanation. The challenge remains to identify any such interacting protein and show how it is able to change the pharmacology of the receptor for different ligands.</jats:p><jats:p><jats:bold>LINKED ARTICLE</jats:bold> This article is a commentary on Nishimune <jats:italic>et al</jats:italic>., pp. 1226–1234 of this issue. To view this paper visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://dx.doi.org/10.1111/j.1476-5381.2011.01591.x">http://dx.doi.org/10.1111/j.1476‐5381.2011.01591.x</jats:ext-link></jats:p> What makes the α<sub>1A</sub>‐adrenoceptor gene express the α<sub>1L</sub>‐adrenoceptor functional phenotype? British Journal of Pharmacology |
| spellingShingle | Ventura, S, British Journal of Pharmacology, What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype?, Pharmacology |
| title | What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_full | What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_fullStr | What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_full_unstemmed | What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_short | What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| title_sort | what makes the α<sub>1a</sub>‐adrenoceptor gene express the α<sub>1l</sub>‐adrenoceptor functional phenotype? |
| title_unstemmed | What makes the α1A‐adrenoceptor gene express the α1L‐adrenoceptor functional phenotype? |
| topic | Pharmacology |
| url | http://dx.doi.org/10.1111/j.1476-5381.2011.01663.x |