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Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease
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| Zeitschriftentitel: | British Journal of Pharmacology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | British Journal of Pharmacology, 158, 2009, 2, S. 413-428 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
de Roos, Baukje Mavrommatis, Yiannis Brouwer, Ingeborg A de Roos, Baukje Mavrommatis, Yiannis Brouwer, Ingeborg A |
|---|---|
| author |
de Roos, Baukje Mavrommatis, Yiannis Brouwer, Ingeborg A |
| spellingShingle |
de Roos, Baukje Mavrommatis, Yiannis Brouwer, Ingeborg A British Journal of Pharmacology Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease Pharmacology |
| author_sort |
de roos, baukje |
| spelling |
de Roos, Baukje Mavrommatis, Yiannis Brouwer, Ingeborg A 0007-1188 1476-5381 Wiley Pharmacology http://dx.doi.org/10.1111/j.1476-5381.2009.00189.x <jats:p>Evidence from observational studies, prospective cohort studies and randomized clinical intervention studies indicate that moderate doses of long‐chain n‐3 polyunsaturated fatty acids (LC n‐3 PUFA) significantly decrease risk of fatal coronary heart disease (CHD). Higher doses and longer duration of intervention may also protect from non‐fatal CHD events. The exact mechanisms through which LC n‐3 PUFA has an effect on CHD are not well established but may include a decrease in fasting and postprandial triacylglycerol levels, a decrease in arrhythmias, modulation of platelet aggregation and decreased synthesis of pro‐inflammatory agents. The mechanistic relation between LC n‐3 PUFA and inflammation has attracted great interest, and <jats:italic>in vitro</jats:italic> studies have revealed that these fatty acids decrease endothelial activation, affect eicosanoid metabolism (including epoxygenation pathways) and induce inflammatory resolution. However, the effects of LC n‐3 PUFA on established biomarkers of inflammation and endothelial activation <jats:italic>in vivo</jats:italic> are not strong. Consequently we need new and more sensitive and systemic biomarkers to reveal the effects of LC n‐3 PUFA on localized inflammatory processes.</jats:p> Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease British Journal of Pharmacology |
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| title |
Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_unstemmed |
Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_full |
Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_fullStr |
Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_full_unstemmed |
Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_short |
Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_sort |
long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
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Pharmacology |
| url |
http://dx.doi.org/10.1111/j.1476-5381.2009.00189.x |
| publishDate |
2009 |
| physical |
413-428 |
| description |
<jats:p>Evidence from observational studies, prospective cohort studies and randomized clinical intervention studies indicate that moderate doses of long‐chain n‐3 polyunsaturated fatty acids (LC n‐3 PUFA) significantly decrease risk of fatal coronary heart disease (CHD). Higher doses and longer duration of intervention may also protect from non‐fatal CHD events. The exact mechanisms through which LC n‐3 PUFA has an effect on CHD are not well established but may include a decrease in fasting and postprandial triacylglycerol levels, a decrease in arrhythmias, modulation of platelet aggregation and decreased synthesis of pro‐inflammatory agents. The mechanistic relation between LC n‐3 PUFA and inflammation has attracted great interest, and <jats:italic>in vitro</jats:italic> studies have revealed that these fatty acids decrease endothelial activation, affect eicosanoid metabolism (including epoxygenation pathways) and induce inflammatory resolution. However, the effects of LC n‐3 PUFA on established biomarkers of inflammation and endothelial activation <jats:italic>in vivo</jats:italic> are not strong. Consequently we need new and more sensitive and systemic biomarkers to reveal the effects of LC n‐3 PUFA on localized inflammatory processes.</jats:p> |
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| description | <jats:p>Evidence from observational studies, prospective cohort studies and randomized clinical intervention studies indicate that moderate doses of long‐chain n‐3 polyunsaturated fatty acids (LC n‐3 PUFA) significantly decrease risk of fatal coronary heart disease (CHD). Higher doses and longer duration of intervention may also protect from non‐fatal CHD events. The exact mechanisms through which LC n‐3 PUFA has an effect on CHD are not well established but may include a decrease in fasting and postprandial triacylglycerol levels, a decrease in arrhythmias, modulation of platelet aggregation and decreased synthesis of pro‐inflammatory agents. The mechanistic relation between LC n‐3 PUFA and inflammation has attracted great interest, and <jats:italic>in vitro</jats:italic> studies have revealed that these fatty acids decrease endothelial activation, affect eicosanoid metabolism (including epoxygenation pathways) and induce inflammatory resolution. However, the effects of LC n‐3 PUFA on established biomarkers of inflammation and endothelial activation <jats:italic>in vivo</jats:italic> are not strong. Consequently we need new and more sensitive and systemic biomarkers to reveal the effects of LC n‐3 PUFA on localized inflammatory processes.</jats:p> |
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| spelling | de Roos, Baukje Mavrommatis, Yiannis Brouwer, Ingeborg A 0007-1188 1476-5381 Wiley Pharmacology http://dx.doi.org/10.1111/j.1476-5381.2009.00189.x <jats:p>Evidence from observational studies, prospective cohort studies and randomized clinical intervention studies indicate that moderate doses of long‐chain n‐3 polyunsaturated fatty acids (LC n‐3 PUFA) significantly decrease risk of fatal coronary heart disease (CHD). Higher doses and longer duration of intervention may also protect from non‐fatal CHD events. The exact mechanisms through which LC n‐3 PUFA has an effect on CHD are not well established but may include a decrease in fasting and postprandial triacylglycerol levels, a decrease in arrhythmias, modulation of platelet aggregation and decreased synthesis of pro‐inflammatory agents. The mechanistic relation between LC n‐3 PUFA and inflammation has attracted great interest, and <jats:italic>in vitro</jats:italic> studies have revealed that these fatty acids decrease endothelial activation, affect eicosanoid metabolism (including epoxygenation pathways) and induce inflammatory resolution. However, the effects of LC n‐3 PUFA on established biomarkers of inflammation and endothelial activation <jats:italic>in vivo</jats:italic> are not strong. Consequently we need new and more sensitive and systemic biomarkers to reveal the effects of LC n‐3 PUFA on localized inflammatory processes.</jats:p> Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease British Journal of Pharmacology |
| spellingShingle | de Roos, Baukje, Mavrommatis, Yiannis, Brouwer, Ingeborg A, British Journal of Pharmacology, Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease, Pharmacology |
| title | Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_full | Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_fullStr | Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_full_unstemmed | Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_short | Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_sort | long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| title_unstemmed | Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease |
| topic | Pharmacology |
| url | http://dx.doi.org/10.1111/j.1476-5381.2009.00189.x |