Eintrag weiter verarbeiten
The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex
Gespeichert in:
| Zeitschriftentitel: | British Journal of Pharmacology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | British Journal of Pharmacology, 107, 1992, 1, S. 5-7 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Tonini, M. Coccini, T. Onori, L. Candura, S.M. Rizzi, C.A. Manzo, L. Tonini, M. Coccini, T. Onori, L. Candura, S.M. Rizzi, C.A. Manzo, L. |
|---|---|
| author |
Tonini, M. Coccini, T. Onori, L. Candura, S.M. Rizzi, C.A. Manzo, L. |
| spellingShingle |
Tonini, M. Coccini, T. Onori, L. Candura, S.M. Rizzi, C.A. Manzo, L. British Journal of Pharmacology The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex Pharmacology |
| author_sort |
tonini, m. |
| spelling |
Tonini, M. Coccini, T. Onori, L. Candura, S.M. Rizzi, C.A. Manzo, L. 0007-1188 1476-5381 Wiley Pharmacology http://dx.doi.org/10.1111/j.1476-5381.1992.tb14455.x <jats:p>A partitioned bath made it possible to separate the site of recording of the ascending excitatory reflex of the ileal circular muscle (oral compartment) from the site of reflex induction (caudal compartment), evoked by inflating an intraluminal balloon. In the caudal compartment, blockade of cholinergic ganglionic transmission by hexamethonium (100 μ<jats:sc>m</jats:sc>) and hyoscine (0.3 μ<jats:sc>m</jats:sc>) caused an approximately 65% reduction in the amplitude of reflex contractions, suggesting that the remaining response was mediated by non‐cholinergic transmission near the distension site. This non‐cholinergic component of ganglionic transmission was insensitive to the action of methiothepin (1 μ<jats:sc>m</jats:sc>), ondansetron (1 μ<jats:sc>m</jats:sc>), tropisetron (1.5 μ<jats:sc>m</jats:sc>), DAU 6285 (1 μ<jats:sc>m</jats:sc>) and renzapride (1 μ<jats:sc>m</jats:sc>), agents that antagonize the action of 5‐hydroxytryptamine (5‐HT) at neural 5‐HT<jats:sub>1</jats:sub>‐like, 5‐HT<jats:sub>3</jats:sub>, 5‐HT<jats:sub>4</jats:sub> and putative 5‐HT<jats:sub>1P</jats:sub> receptors. These findings suggest that the neural pathways subserving non‐cholinergic ganglionic transmission in the ascending excitatory reflex in the guinea‐pig ileum do not involve 5‐HT as neurotransmitter.</jats:p> The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex British Journal of Pharmacology |
| doi_str_mv |
10.1111/j.1476-5381.1992.tb14455.x |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE0NzYtNTM4MS4xOTkyLnRiMTQ0NTUueA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE0NzYtNTM4MS4xOTkyLnRiMTQ0NTUueA |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Wiley, 1992 |
| imprint_str_mv |
Wiley, 1992 |
| issn |
0007-1188 1476-5381 |
| issn_str_mv |
0007-1188 1476-5381 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
tonini1992theinfluenceofneuronal5hydroxytryptaminereceptorantagonistsonnoncholinergicganglionictransmissionintheguineapigentericexcitatoryreflex |
| publishDateSort |
1992 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
British Journal of Pharmacology |
| source_id |
49 |
| title |
The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_unstemmed |
The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_full |
The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_fullStr |
The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_full_unstemmed |
The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_short |
The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_sort |
the influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| topic |
Pharmacology |
| url |
http://dx.doi.org/10.1111/j.1476-5381.1992.tb14455.x |
| publishDate |
1992 |
| physical |
5-7 |
| description |
<jats:p>A partitioned bath made it possible to separate the site of recording of the ascending excitatory reflex of the ileal circular muscle (oral compartment) from the site of reflex induction (caudal compartment), evoked by inflating an intraluminal balloon. In the caudal compartment, blockade of cholinergic ganglionic transmission by hexamethonium (100 μ<jats:sc>m</jats:sc>) and hyoscine (0.3 μ<jats:sc>m</jats:sc>) caused an approximately 65% reduction in the amplitude of reflex contractions, suggesting that the remaining response was mediated by non‐cholinergic transmission near the distension site. This non‐cholinergic component of ganglionic transmission was insensitive to the action of methiothepin (1 μ<jats:sc>m</jats:sc>), ondansetron (1 μ<jats:sc>m</jats:sc>), tropisetron (1.5 μ<jats:sc>m</jats:sc>), DAU 6285 (1 μ<jats:sc>m</jats:sc>) and renzapride (1 μ<jats:sc>m</jats:sc>), agents that antagonize the action of 5‐hydroxytryptamine (5‐HT) at neural 5‐HT<jats:sub>1</jats:sub>‐like, 5‐HT<jats:sub>3</jats:sub>, 5‐HT<jats:sub>4</jats:sub> and putative 5‐HT<jats:sub>1P</jats:sub> receptors. These findings suggest that the neural pathways subserving non‐cholinergic ganglionic transmission in the ascending excitatory reflex in the guinea‐pig ileum do not involve 5‐HT as neurotransmitter.</jats:p> |
| container_issue |
1 |
| container_start_page |
5 |
| container_title |
British Journal of Pharmacology |
| container_volume |
107 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336647104233483 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:03:45.31Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+influence+of+neuronal+5%E2%80%90hydroxytryptamine+receptor+antagonists+on+non%E2%80%90cholinergic+ganglionic+transmission+in+the+guinea%E2%80%90pig+enteric+excitatory+reflex&rft.date=1992-09-01&genre=article&issn=1476-5381&volume=107&issue=1&spage=5&epage=7&pages=5-7&jtitle=British+Journal+of+Pharmacology&atitle=The+influence+of+neuronal+5%E2%80%90hydroxytryptamine+receptor+antagonists+on+non%E2%80%90cholinergic+ganglionic+transmission+in+the+guinea%E2%80%90pig+enteric+excitatory+reflex&aulast=Manzo&aufirst=L.&rft_id=info%3Adoi%2F10.1111%2Fj.1476-5381.1992.tb14455.x&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336647104233483 |
| author | Tonini, M., Coccini, T., Onori, L., Candura, S.M., Rizzi, C.A., Manzo, L. |
| author_facet | Tonini, M., Coccini, T., Onori, L., Candura, S.M., Rizzi, C.A., Manzo, L., Tonini, M., Coccini, T., Onori, L., Candura, S.M., Rizzi, C.A., Manzo, L. |
| author_sort | tonini, m. |
| container_issue | 1 |
| container_start_page | 5 |
| container_title | British Journal of Pharmacology |
| container_volume | 107 |
| description | <jats:p>A partitioned bath made it possible to separate the site of recording of the ascending excitatory reflex of the ileal circular muscle (oral compartment) from the site of reflex induction (caudal compartment), evoked by inflating an intraluminal balloon. In the caudal compartment, blockade of cholinergic ganglionic transmission by hexamethonium (100 μ<jats:sc>m</jats:sc>) and hyoscine (0.3 μ<jats:sc>m</jats:sc>) caused an approximately 65% reduction in the amplitude of reflex contractions, suggesting that the remaining response was mediated by non‐cholinergic transmission near the distension site. This non‐cholinergic component of ganglionic transmission was insensitive to the action of methiothepin (1 μ<jats:sc>m</jats:sc>), ondansetron (1 μ<jats:sc>m</jats:sc>), tropisetron (1.5 μ<jats:sc>m</jats:sc>), DAU 6285 (1 μ<jats:sc>m</jats:sc>) and renzapride (1 μ<jats:sc>m</jats:sc>), agents that antagonize the action of 5‐hydroxytryptamine (5‐HT) at neural 5‐HT<jats:sub>1</jats:sub>‐like, 5‐HT<jats:sub>3</jats:sub>, 5‐HT<jats:sub>4</jats:sub> and putative 5‐HT<jats:sub>1P</jats:sub> receptors. These findings suggest that the neural pathways subserving non‐cholinergic ganglionic transmission in the ascending excitatory reflex in the guinea‐pig ileum do not involve 5‐HT as neurotransmitter.</jats:p> |
| doi_str_mv | 10.1111/j.1476-5381.1992.tb14455.x |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE0NzYtNTM4MS4xOTkyLnRiMTQ0NTUueA |
| imprint | Wiley, 1992 |
| imprint_str_mv | Wiley, 1992 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0007-1188, 1476-5381 |
| issn_str_mv | 0007-1188, 1476-5381 |
| language | English |
| last_indexed | 2024-03-01T15:03:45.31Z |
| match_str | tonini1992theinfluenceofneuronal5hydroxytryptaminereceptorantagonistsonnoncholinergicganglionictransmissionintheguineapigentericexcitatoryreflex |
| mega_collection | Wiley (CrossRef) |
| physical | 5-7 |
| publishDate | 1992 |
| publishDateSort | 1992 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | British Journal of Pharmacology |
| source_id | 49 |
| spelling | Tonini, M. Coccini, T. Onori, L. Candura, S.M. Rizzi, C.A. Manzo, L. 0007-1188 1476-5381 Wiley Pharmacology http://dx.doi.org/10.1111/j.1476-5381.1992.tb14455.x <jats:p>A partitioned bath made it possible to separate the site of recording of the ascending excitatory reflex of the ileal circular muscle (oral compartment) from the site of reflex induction (caudal compartment), evoked by inflating an intraluminal balloon. In the caudal compartment, blockade of cholinergic ganglionic transmission by hexamethonium (100 μ<jats:sc>m</jats:sc>) and hyoscine (0.3 μ<jats:sc>m</jats:sc>) caused an approximately 65% reduction in the amplitude of reflex contractions, suggesting that the remaining response was mediated by non‐cholinergic transmission near the distension site. This non‐cholinergic component of ganglionic transmission was insensitive to the action of methiothepin (1 μ<jats:sc>m</jats:sc>), ondansetron (1 μ<jats:sc>m</jats:sc>), tropisetron (1.5 μ<jats:sc>m</jats:sc>), DAU 6285 (1 μ<jats:sc>m</jats:sc>) and renzapride (1 μ<jats:sc>m</jats:sc>), agents that antagonize the action of 5‐hydroxytryptamine (5‐HT) at neural 5‐HT<jats:sub>1</jats:sub>‐like, 5‐HT<jats:sub>3</jats:sub>, 5‐HT<jats:sub>4</jats:sub> and putative 5‐HT<jats:sub>1P</jats:sub> receptors. These findings suggest that the neural pathways subserving non‐cholinergic ganglionic transmission in the ascending excitatory reflex in the guinea‐pig ileum do not involve 5‐HT as neurotransmitter.</jats:p> The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex British Journal of Pharmacology |
| spellingShingle | Tonini, M., Coccini, T., Onori, L., Candura, S.M., Rizzi, C.A., Manzo, L., British Journal of Pharmacology, The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex, Pharmacology |
| title | The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_full | The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_fullStr | The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_full_unstemmed | The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_short | The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_sort | the influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| title_unstemmed | The influence of neuronal 5‐hydroxytryptamine receptor antagonists on non‐cholinergic ganglionic transmission in the guinea‐pig enteric excitatory reflex |
| topic | Pharmacology |
| url | http://dx.doi.org/10.1111/j.1476-5381.1992.tb14455.x |