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LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans
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| Zeitschriftentitel: | Aging Cell |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Aging Cell, 4, 2005, 5, S. 235-245 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Nanji, Manoj Hopper, Neil A. Gems, David Nanji, Manoj Hopper, Neil A. Gems, David |
|---|---|
| author |
Nanji, Manoj Hopper, Neil A. Gems, David |
| spellingShingle |
Nanji, Manoj Hopper, Neil A. Gems, David Aging Cell LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans Cell Biology Aging |
| author_sort |
nanji, manoj |
| spelling |
Nanji, Manoj Hopper, Neil A. Gems, David 1474-9718 1474-9726 Wiley Cell Biology Aging http://dx.doi.org/10.1111/j.1474-9726.2005.00166.x <jats:title>Summary</jats:title><jats:p>The DAF‐2 insulin/insulin‐like growth factor 1 (IGF‐1) receptor signals via a phosphatidylinositol 3‐kinase (PI3K) pathway to control dauer larva formation and adult longevity in <jats:italic>Caenorhabditis elegans</jats:italic>. Yet epistasis analysis suggests signal bifurcation downstream of DAF‐2. We have used epistasis analysis to test whether the Ras pathway (which plays a role in signaling from mammalian insulin receptors) acts downstream of DAF‐2. We find that an activated Ras mutation, <jats:italic>let‐60(n1046gf)</jats:italic>, weakly suppresses constitutive dauer diapause in <jats:italic>daf‐2</jats:italic> and <jats:italic>age‐1</jats:italic> (PI3K) mutants. Moreover, increased Ras pathway signaling partially suppresses the <jats:italic>daf‐2</jats:italic> mutant feeding defect, while reduced Ras pathway signaling enhances it. By contrast, activated Ras extends the longevity induced by mutation of daf‐2, while reduced Ras pathway signaling partially suppresses it. Thus, Ras pathway signaling appears to act with insulin/IGF‐1 signaling during larval development, but against it during aging.</jats:p> LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in <i>Caenorhabditis elegans</i> Aging Cell |
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10.1111/j.1474-9726.2005.00166.x |
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Wiley, 2005 |
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Aging Cell |
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| title |
LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_unstemmed |
LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_full |
LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_fullStr |
LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_full_unstemmed |
LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_short |
LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_sort |
let‐60 ras modulates effects of insulin/igf‐1 signaling on development and aging in <i>caenorhabditis elegans</i> |
| topic |
Cell Biology Aging |
| url |
http://dx.doi.org/10.1111/j.1474-9726.2005.00166.x |
| publishDate |
2005 |
| physical |
235-245 |
| description |
<jats:title>Summary</jats:title><jats:p>The DAF‐2 insulin/insulin‐like growth factor 1 (IGF‐1) receptor signals via a phosphatidylinositol 3‐kinase (PI3K) pathway to control dauer larva formation and adult longevity in <jats:italic>Caenorhabditis elegans</jats:italic>. Yet epistasis analysis suggests signal bifurcation downstream of DAF‐2. We have used epistasis analysis to test whether the Ras pathway (which plays a role in signaling from mammalian insulin receptors) acts downstream of DAF‐2. We find that an activated Ras mutation, <jats:italic>let‐60(n1046gf)</jats:italic>, weakly suppresses constitutive dauer diapause in <jats:italic>daf‐2</jats:italic> and <jats:italic>age‐1</jats:italic> (PI3K) mutants. Moreover, increased Ras pathway signaling partially suppresses the <jats:italic>daf‐2</jats:italic> mutant feeding defect, while reduced Ras pathway signaling enhances it. By contrast, activated Ras extends the longevity induced by mutation of daf‐2, while reduced Ras pathway signaling partially suppresses it. Thus, Ras pathway signaling appears to act with insulin/IGF‐1 signaling during larval development, but against it during aging.</jats:p> |
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| author | Nanji, Manoj, Hopper, Neil A., Gems, David |
| author_facet | Nanji, Manoj, Hopper, Neil A., Gems, David, Nanji, Manoj, Hopper, Neil A., Gems, David |
| author_sort | nanji, manoj |
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| container_start_page | 235 |
| container_title | Aging Cell |
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| description | <jats:title>Summary</jats:title><jats:p>The DAF‐2 insulin/insulin‐like growth factor 1 (IGF‐1) receptor signals via a phosphatidylinositol 3‐kinase (PI3K) pathway to control dauer larva formation and adult longevity in <jats:italic>Caenorhabditis elegans</jats:italic>. Yet epistasis analysis suggests signal bifurcation downstream of DAF‐2. We have used epistasis analysis to test whether the Ras pathway (which plays a role in signaling from mammalian insulin receptors) acts downstream of DAF‐2. We find that an activated Ras mutation, <jats:italic>let‐60(n1046gf)</jats:italic>, weakly suppresses constitutive dauer diapause in <jats:italic>daf‐2</jats:italic> and <jats:italic>age‐1</jats:italic> (PI3K) mutants. Moreover, increased Ras pathway signaling partially suppresses the <jats:italic>daf‐2</jats:italic> mutant feeding defect, while reduced Ras pathway signaling enhances it. By contrast, activated Ras extends the longevity induced by mutation of daf‐2, while reduced Ras pathway signaling partially suppresses it. Thus, Ras pathway signaling appears to act with insulin/IGF‐1 signaling during larval development, but against it during aging.</jats:p> |
| doi_str_mv | 10.1111/j.1474-9726.2005.00166.x |
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| imprint | Wiley, 2005 |
| imprint_str_mv | Wiley, 2005 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 1474-9718, 1474-9726 |
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| language | English |
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| physical | 235-245 |
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| series | Aging Cell |
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| spelling | Nanji, Manoj Hopper, Neil A. Gems, David 1474-9718 1474-9726 Wiley Cell Biology Aging http://dx.doi.org/10.1111/j.1474-9726.2005.00166.x <jats:title>Summary</jats:title><jats:p>The DAF‐2 insulin/insulin‐like growth factor 1 (IGF‐1) receptor signals via a phosphatidylinositol 3‐kinase (PI3K) pathway to control dauer larva formation and adult longevity in <jats:italic>Caenorhabditis elegans</jats:italic>. Yet epistasis analysis suggests signal bifurcation downstream of DAF‐2. We have used epistasis analysis to test whether the Ras pathway (which plays a role in signaling from mammalian insulin receptors) acts downstream of DAF‐2. We find that an activated Ras mutation, <jats:italic>let‐60(n1046gf)</jats:italic>, weakly suppresses constitutive dauer diapause in <jats:italic>daf‐2</jats:italic> and <jats:italic>age‐1</jats:italic> (PI3K) mutants. Moreover, increased Ras pathway signaling partially suppresses the <jats:italic>daf‐2</jats:italic> mutant feeding defect, while reduced Ras pathway signaling enhances it. By contrast, activated Ras extends the longevity induced by mutation of daf‐2, while reduced Ras pathway signaling partially suppresses it. Thus, Ras pathway signaling appears to act with insulin/IGF‐1 signaling during larval development, but against it during aging.</jats:p> LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in <i>Caenorhabditis elegans</i> Aging Cell |
| spellingShingle | Nanji, Manoj, Hopper, Neil A., Gems, David, Aging Cell, LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans, Cell Biology, Aging |
| title | LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_full | LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_fullStr | LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_full_unstemmed | LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_short | LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| title_sort | let‐60 ras modulates effects of insulin/igf‐1 signaling on development and aging in <i>caenorhabditis elegans</i> |
| title_unstemmed | LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans |
| topic | Cell Biology, Aging |
| url | http://dx.doi.org/10.1111/j.1474-9726.2005.00166.x |