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Mitochondria as all‐round players of the calcium game
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| Zeitschriftentitel: | The Journal of Physiology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of Physiology, 529, 2000, 1, S. 37-47 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Rizzuto, Rosario Bernardi, Paolo Pozzan, Tullio Rizzuto, Rosario Bernardi, Paolo Pozzan, Tullio |
|---|---|
| author |
Rizzuto, Rosario Bernardi, Paolo Pozzan, Tullio |
| spellingShingle |
Rizzuto, Rosario Bernardi, Paolo Pozzan, Tullio The Journal of Physiology Mitochondria as all‐round players of the calcium game Physiology |
| author_sort |
rizzuto, rosario |
| spelling |
Rizzuto, Rosario Bernardi, Paolo Pozzan, Tullio 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1111/j.1469-7793.2000.00037.x <jats:p>Although it has been known for over three decades that mitochondria are endowed with a complex array of Ca<jats:sup>2+</jats:sup> transporters and that key enzymes of mitochondrial metabolism are regulated by Ca<jats:sup>2+</jats:sup>, the possibility that physiological stimuli that raise the [Ca<jats:sup>2+</jats:sup>] of the cytoplasm could trigger major mitochondrial Ca<jats:sup>2+</jats:sup> uptake has long been considered unlikely, based on the low affinity of the mitochondrial transporters and the limited amplitude of the cytoplasmic [Ca<jats:sup>2+</jats:sup>] rises. The direct measurement of mitochondrial [Ca<jats:sup>2+</jats:sup>] with highly selective probes has led to a complete reversion of this view, by demonstrating that, after cell stimulation, the cytoplasmic Ca<jats:sup>2+</jats:sup> signal is always paralleled by a much larger rise in [Ca<jats:sup>2+</jats:sup>] in the mitochondrial matrix. This observation has rejuvenated the study of mitochondrial Ca<jats:sup>2+</jats:sup> transport and novel, unexpected results have altered long‐standing dogmas in the field of calcium signalling. Here we focus on four main topics: (i) the current knowledge of the functional properties of the Ca<jats:sup>2+</jats:sup> transporters and of the thermodynamic constraints under which they operate; (ii) the occurrence of mitochondrial Ca<jats:sup>2+</jats:sup> uptake in living cells and the key role of local signalling routes between the mitochondria and the Ca<jats:sup>2+</jats:sup> sources; (iii) the physiological consequences of Ca<jats:sup>2+</jats:sup> transport for both mitochondrial function and the modulation of the cytoplasmic Ca<jats:sup>2+</jats:sup> signal; and (iv) evidence that alterations of mitochondrial Ca<jats:sup>2+</jats:sup> signalling may occur in pathophysiological conditions.</jats:p> Mitochondria as all‐round players of the calcium game The Journal of Physiology |
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| title |
Mitochondria as all‐round players of the calcium game |
| title_unstemmed |
Mitochondria as all‐round players of the calcium game |
| title_full |
Mitochondria as all‐round players of the calcium game |
| title_fullStr |
Mitochondria as all‐round players of the calcium game |
| title_full_unstemmed |
Mitochondria as all‐round players of the calcium game |
| title_short |
Mitochondria as all‐round players of the calcium game |
| title_sort |
mitochondria as all‐round players of the calcium game |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1111/j.1469-7793.2000.00037.x |
| publishDate |
2000 |
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37-47 |
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<jats:p>Although it has been known for over three decades that mitochondria are endowed with a complex array of Ca<jats:sup>2+</jats:sup> transporters and that key enzymes of mitochondrial metabolism are regulated by Ca<jats:sup>2+</jats:sup>, the possibility that physiological stimuli that raise the [Ca<jats:sup>2+</jats:sup>] of the cytoplasm could trigger major mitochondrial Ca<jats:sup>2+</jats:sup> uptake has long been considered unlikely, based on the low affinity of the mitochondrial transporters and the limited amplitude of the cytoplasmic [Ca<jats:sup>2+</jats:sup>] rises. The direct measurement of mitochondrial [Ca<jats:sup>2+</jats:sup>] with highly selective probes has led to a complete reversion of this view, by demonstrating that, after cell stimulation, the cytoplasmic Ca<jats:sup>2+</jats:sup> signal is always paralleled by a much larger rise in [Ca<jats:sup>2+</jats:sup>] in the mitochondrial matrix. This observation has rejuvenated the study of mitochondrial Ca<jats:sup>2+</jats:sup> transport and novel, unexpected results have altered long‐standing dogmas in the field of calcium signalling. Here we focus on four main topics: (i) the current knowledge of the functional properties of the Ca<jats:sup>2+</jats:sup> transporters and of the thermodynamic constraints under which they operate; (ii) the occurrence of mitochondrial Ca<jats:sup>2+</jats:sup> uptake in living cells and the key role of local signalling routes between the mitochondria and the Ca<jats:sup>2+</jats:sup> sources; (iii) the physiological consequences of Ca<jats:sup>2+</jats:sup> transport for both mitochondrial function and the modulation of the cytoplasmic Ca<jats:sup>2+</jats:sup> signal; and (iv) evidence that alterations of mitochondrial Ca<jats:sup>2+</jats:sup> signalling may occur in pathophysiological conditions.</jats:p> |
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| description | <jats:p>Although it has been known for over three decades that mitochondria are endowed with a complex array of Ca<jats:sup>2+</jats:sup> transporters and that key enzymes of mitochondrial metabolism are regulated by Ca<jats:sup>2+</jats:sup>, the possibility that physiological stimuli that raise the [Ca<jats:sup>2+</jats:sup>] of the cytoplasm could trigger major mitochondrial Ca<jats:sup>2+</jats:sup> uptake has long been considered unlikely, based on the low affinity of the mitochondrial transporters and the limited amplitude of the cytoplasmic [Ca<jats:sup>2+</jats:sup>] rises. The direct measurement of mitochondrial [Ca<jats:sup>2+</jats:sup>] with highly selective probes has led to a complete reversion of this view, by demonstrating that, after cell stimulation, the cytoplasmic Ca<jats:sup>2+</jats:sup> signal is always paralleled by a much larger rise in [Ca<jats:sup>2+</jats:sup>] in the mitochondrial matrix. This observation has rejuvenated the study of mitochondrial Ca<jats:sup>2+</jats:sup> transport and novel, unexpected results have altered long‐standing dogmas in the field of calcium signalling. Here we focus on four main topics: (i) the current knowledge of the functional properties of the Ca<jats:sup>2+</jats:sup> transporters and of the thermodynamic constraints under which they operate; (ii) the occurrence of mitochondrial Ca<jats:sup>2+</jats:sup> uptake in living cells and the key role of local signalling routes between the mitochondria and the Ca<jats:sup>2+</jats:sup> sources; (iii) the physiological consequences of Ca<jats:sup>2+</jats:sup> transport for both mitochondrial function and the modulation of the cytoplasmic Ca<jats:sup>2+</jats:sup> signal; and (iv) evidence that alterations of mitochondrial Ca<jats:sup>2+</jats:sup> signalling may occur in pathophysiological conditions.</jats:p> |
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| spelling | Rizzuto, Rosario Bernardi, Paolo Pozzan, Tullio 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1111/j.1469-7793.2000.00037.x <jats:p>Although it has been known for over three decades that mitochondria are endowed with a complex array of Ca<jats:sup>2+</jats:sup> transporters and that key enzymes of mitochondrial metabolism are regulated by Ca<jats:sup>2+</jats:sup>, the possibility that physiological stimuli that raise the [Ca<jats:sup>2+</jats:sup>] of the cytoplasm could trigger major mitochondrial Ca<jats:sup>2+</jats:sup> uptake has long been considered unlikely, based on the low affinity of the mitochondrial transporters and the limited amplitude of the cytoplasmic [Ca<jats:sup>2+</jats:sup>] rises. The direct measurement of mitochondrial [Ca<jats:sup>2+</jats:sup>] with highly selective probes has led to a complete reversion of this view, by demonstrating that, after cell stimulation, the cytoplasmic Ca<jats:sup>2+</jats:sup> signal is always paralleled by a much larger rise in [Ca<jats:sup>2+</jats:sup>] in the mitochondrial matrix. This observation has rejuvenated the study of mitochondrial Ca<jats:sup>2+</jats:sup> transport and novel, unexpected results have altered long‐standing dogmas in the field of calcium signalling. Here we focus on four main topics: (i) the current knowledge of the functional properties of the Ca<jats:sup>2+</jats:sup> transporters and of the thermodynamic constraints under which they operate; (ii) the occurrence of mitochondrial Ca<jats:sup>2+</jats:sup> uptake in living cells and the key role of local signalling routes between the mitochondria and the Ca<jats:sup>2+</jats:sup> sources; (iii) the physiological consequences of Ca<jats:sup>2+</jats:sup> transport for both mitochondrial function and the modulation of the cytoplasmic Ca<jats:sup>2+</jats:sup> signal; and (iv) evidence that alterations of mitochondrial Ca<jats:sup>2+</jats:sup> signalling may occur in pathophysiological conditions.</jats:p> Mitochondria as all‐round players of the calcium game The Journal of Physiology |
| spellingShingle | Rizzuto, Rosario, Bernardi, Paolo, Pozzan, Tullio, The Journal of Physiology, Mitochondria as all‐round players of the calcium game, Physiology |
| title | Mitochondria as all‐round players of the calcium game |
| title_full | Mitochondria as all‐round players of the calcium game |
| title_fullStr | Mitochondria as all‐round players of the calcium game |
| title_full_unstemmed | Mitochondria as all‐round players of the calcium game |
| title_short | Mitochondria as all‐round players of the calcium game |
| title_sort | mitochondria as all‐round players of the calcium game |
| title_unstemmed | Mitochondria as all‐round players of the calcium game |
| topic | Physiology |
| url | http://dx.doi.org/10.1111/j.1469-7793.2000.00037.x |