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Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development
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| Zeitschriftentitel: | Journal of Anatomy |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Anatomy, 209, 2006, 4, S. 447-468 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Ripamonti, Ugo Ferretti, C. Heliotis, M. Ripamonti, Ugo Ferretti, C. Heliotis, M. |
|---|---|
| author |
Ripamonti, Ugo Ferretti, C. Heliotis, M. |
| spellingShingle |
Ripamonti, Ugo Ferretti, C. Heliotis, M. Journal of Anatomy Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development Cell Biology Developmental Biology Molecular Biology Ecology, Evolution, Behavior and Systematics Histology Anatomy |
| author_sort |
ripamonti, ugo |
| spelling |
Ripamonti, Ugo Ferretti, C. Heliotis, M. 0021-8782 1469-7580 Wiley Cell Biology Developmental Biology Molecular Biology Ecology, Evolution, Behavior and Systematics Histology Anatomy http://dx.doi.org/10.1111/j.1469-7580.2006.00635.x <jats:title>Abstract</jats:title><jats:p>The osteogenic molecular signals of the transforming growth factor‐β (TGF‐β) superfamily, the bone morphogenetic/osteogenic proteins (BMPs/OPs) and uniquely in primates the TGF‐β isoforms <jats:italic>per se</jats:italic>, pleiotropic members of the TGF‐β supergene family, induce <jats:italic>de novo</jats:italic> endochondral bone formation as a recapitulation of embryonic development. Naturally derived BMPs/OPs and gamma‐irradiated human recombinant osteogenic protein‐1 (hOP‐1) delivered by allogeneic and xenogeneic insoluble collagenous matrices initiate <jats:italic>de novo</jats:italic> bone induction in heterotopic and orthotopic sites of the primate <jats:italic>Papio ursinus</jats:italic>, culminating in complete calvarial regeneration by day 90 and maintaining the regenerated structures by day 365. The induction of bone by hOP‐1 in <jats:italic>P. ursinus</jats:italic> develops as a <jats:italic>mosaic</jats:italic> structure with distinct spatial and temporal patterns of gene expression of members of the TGF‐β superfamily that singly, synergistically and synchronously initiate and maintain tissue induction and morphogenesis. The temporal and spatial expressions of TGF‐β1 mRNA indicate a specific temporal transcriptional window during which expression of TGF‐β1 is mandatory for successful and optimal osteogenesis. Highly purified naturally derived bovine BMPs/OPs and hOP‐1 delivered by human collagenous bone matrices and porous hydroxyapatite, respectively, induce bone formation in mandibular defects of human patients. By using healthy body sites as bioreactors it is possible to recapitulate embryonic developments by inducing selected biomaterials combined with recombinant proteins to transform into custom‐made prefabricated bone grafts for human reconstruction. The osteogenic proteins of the TGF‐β superfamily, BMPs/OPs and TGF‐βs, the last endowed with the striking prerogative of inducing endochondral bone formation in primates only, are helping to engineer skeletal reconstruction in molecular terms.</jats:p> Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development Journal of Anatomy |
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| title |
Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_unstemmed |
Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_full |
Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_fullStr |
Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_full_unstemmed |
Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_short |
Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_sort |
soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| topic |
Cell Biology Developmental Biology Molecular Biology Ecology, Evolution, Behavior and Systematics Histology Anatomy |
| url |
http://dx.doi.org/10.1111/j.1469-7580.2006.00635.x |
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2006 |
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447-468 |
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<jats:title>Abstract</jats:title><jats:p>The osteogenic molecular signals of the transforming growth factor‐β (TGF‐β) superfamily, the bone morphogenetic/osteogenic proteins (BMPs/OPs) and uniquely in primates the TGF‐β isoforms <jats:italic>per se</jats:italic>, pleiotropic members of the TGF‐β supergene family, induce <jats:italic>de novo</jats:italic> endochondral bone formation as a recapitulation of embryonic development. Naturally derived BMPs/OPs and gamma‐irradiated human recombinant osteogenic protein‐1 (hOP‐1) delivered by allogeneic and xenogeneic insoluble collagenous matrices initiate <jats:italic>de novo</jats:italic> bone induction in heterotopic and orthotopic sites of the primate <jats:italic>Papio ursinus</jats:italic>, culminating in complete calvarial regeneration by day 90 and maintaining the regenerated structures by day 365. The induction of bone by hOP‐1 in <jats:italic>P. ursinus</jats:italic> develops as a <jats:italic>mosaic</jats:italic> structure with distinct spatial and temporal patterns of gene expression of members of the TGF‐β superfamily that singly, synergistically and synchronously initiate and maintain tissue induction and morphogenesis. The temporal and spatial expressions of TGF‐β1 mRNA indicate a specific temporal transcriptional window during which expression of TGF‐β1 is mandatory for successful and optimal osteogenesis. Highly purified naturally derived bovine BMPs/OPs and hOP‐1 delivered by human collagenous bone matrices and porous hydroxyapatite, respectively, induce bone formation in mandibular defects of human patients. By using healthy body sites as bioreactors it is possible to recapitulate embryonic developments by inducing selected biomaterials combined with recombinant proteins to transform into custom‐made prefabricated bone grafts for human reconstruction. The osteogenic proteins of the TGF‐β superfamily, BMPs/OPs and TGF‐βs, the last endowed with the striking prerogative of inducing endochondral bone formation in primates only, are helping to engineer skeletal reconstruction in molecular terms.</jats:p> |
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| description | <jats:title>Abstract</jats:title><jats:p>The osteogenic molecular signals of the transforming growth factor‐β (TGF‐β) superfamily, the bone morphogenetic/osteogenic proteins (BMPs/OPs) and uniquely in primates the TGF‐β isoforms <jats:italic>per se</jats:italic>, pleiotropic members of the TGF‐β supergene family, induce <jats:italic>de novo</jats:italic> endochondral bone formation as a recapitulation of embryonic development. Naturally derived BMPs/OPs and gamma‐irradiated human recombinant osteogenic protein‐1 (hOP‐1) delivered by allogeneic and xenogeneic insoluble collagenous matrices initiate <jats:italic>de novo</jats:italic> bone induction in heterotopic and orthotopic sites of the primate <jats:italic>Papio ursinus</jats:italic>, culminating in complete calvarial regeneration by day 90 and maintaining the regenerated structures by day 365. The induction of bone by hOP‐1 in <jats:italic>P. ursinus</jats:italic> develops as a <jats:italic>mosaic</jats:italic> structure with distinct spatial and temporal patterns of gene expression of members of the TGF‐β superfamily that singly, synergistically and synchronously initiate and maintain tissue induction and morphogenesis. The temporal and spatial expressions of TGF‐β1 mRNA indicate a specific temporal transcriptional window during which expression of TGF‐β1 is mandatory for successful and optimal osteogenesis. Highly purified naturally derived bovine BMPs/OPs and hOP‐1 delivered by human collagenous bone matrices and porous hydroxyapatite, respectively, induce bone formation in mandibular defects of human patients. By using healthy body sites as bioreactors it is possible to recapitulate embryonic developments by inducing selected biomaterials combined with recombinant proteins to transform into custom‐made prefabricated bone grafts for human reconstruction. The osteogenic proteins of the TGF‐β superfamily, BMPs/OPs and TGF‐βs, the last endowed with the striking prerogative of inducing endochondral bone formation in primates only, are helping to engineer skeletal reconstruction in molecular terms.</jats:p> |
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| spelling | Ripamonti, Ugo Ferretti, C. Heliotis, M. 0021-8782 1469-7580 Wiley Cell Biology Developmental Biology Molecular Biology Ecology, Evolution, Behavior and Systematics Histology Anatomy http://dx.doi.org/10.1111/j.1469-7580.2006.00635.x <jats:title>Abstract</jats:title><jats:p>The osteogenic molecular signals of the transforming growth factor‐β (TGF‐β) superfamily, the bone morphogenetic/osteogenic proteins (BMPs/OPs) and uniquely in primates the TGF‐β isoforms <jats:italic>per se</jats:italic>, pleiotropic members of the TGF‐β supergene family, induce <jats:italic>de novo</jats:italic> endochondral bone formation as a recapitulation of embryonic development. Naturally derived BMPs/OPs and gamma‐irradiated human recombinant osteogenic protein‐1 (hOP‐1) delivered by allogeneic and xenogeneic insoluble collagenous matrices initiate <jats:italic>de novo</jats:italic> bone induction in heterotopic and orthotopic sites of the primate <jats:italic>Papio ursinus</jats:italic>, culminating in complete calvarial regeneration by day 90 and maintaining the regenerated structures by day 365. The induction of bone by hOP‐1 in <jats:italic>P. ursinus</jats:italic> develops as a <jats:italic>mosaic</jats:italic> structure with distinct spatial and temporal patterns of gene expression of members of the TGF‐β superfamily that singly, synergistically and synchronously initiate and maintain tissue induction and morphogenesis. The temporal and spatial expressions of TGF‐β1 mRNA indicate a specific temporal transcriptional window during which expression of TGF‐β1 is mandatory for successful and optimal osteogenesis. Highly purified naturally derived bovine BMPs/OPs and hOP‐1 delivered by human collagenous bone matrices and porous hydroxyapatite, respectively, induce bone formation in mandibular defects of human patients. By using healthy body sites as bioreactors it is possible to recapitulate embryonic developments by inducing selected biomaterials combined with recombinant proteins to transform into custom‐made prefabricated bone grafts for human reconstruction. The osteogenic proteins of the TGF‐β superfamily, BMPs/OPs and TGF‐βs, the last endowed with the striking prerogative of inducing endochondral bone formation in primates only, are helping to engineer skeletal reconstruction in molecular terms.</jats:p> Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development Journal of Anatomy |
| spellingShingle | Ripamonti, Ugo, Ferretti, C., Heliotis, M., Journal of Anatomy, Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development, Cell Biology, Developmental Biology, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Histology, Anatomy |
| title | Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_full | Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_fullStr | Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_full_unstemmed | Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_short | Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_sort | soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| title_unstemmed | Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development |
| topic | Cell Biology, Developmental Biology, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Histology, Anatomy |
| url | http://dx.doi.org/10.1111/j.1469-7580.2006.00635.x |