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Telomeres in a Life-Span Perspective : A New “Psychobiomarker”?: A New “Psychobiomarker”?
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| Zeitschriftentitel: | Current Directions in Psychological Science |
|---|---|
| Personen und Körperschaften: | |
| In: | Current Directions in Psychological Science, 18, 2009, 1, S. 6-10 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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Epel, Elissa S. Epel, Elissa S. |
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Epel, Elissa S. |
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Epel, Elissa S. Current Directions in Psychological Science Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? General Psychology |
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Epel, Elissa S. 0963-7214 1467-8721 SAGE Publications General Psychology http://dx.doi.org/10.1111/j.1467-8721.2009.01596.x <jats:p> In order to more fully understand associations between psychological stress and health, it is helpful for researchers to identify “psychobiomarkers,” or biological measures that are regulated in part by psychological function and that predict longevity. Telomere length appears to be such a measure. Telomeres, the protective caps at the tips of chromosomes, shorten with age, and this shortening predicts disease and longevity. Leukocyte telomere length may be best viewed through a life-span approach, as it reflects in part the cumulative number of cell divisions that have occurred and the long-term biochemical environment. Recently, a critical mass of studies demonstrated that telomeres appear to shorten with chronic stress, although the mechanisms are unknown. This paper reviews what appear to be malleable determinants of rate of telomere attrition, focusing on early life chronic stressors and metabolic adversity (poor nutrition during development, and obesity). The next generation of research will benefit from experimental and longitudinal models integrating genetic variation, social environments, life experience, and health behaviors. </jats:p> A New “Psychobiomarker”? Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? Current Directions in Psychological Science |
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A New “Psychobiomarker”? |
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Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
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Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
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Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
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Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
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Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
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Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
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telomeres in a life-span perspective : a new “psychobiomarker”? |
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General Psychology |
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http://dx.doi.org/10.1111/j.1467-8721.2009.01596.x |
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6-10 |
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<jats:p> In order to more fully understand associations between psychological stress and health, it is helpful for researchers to identify “psychobiomarkers,” or biological measures that are regulated in part by psychological function and that predict longevity. Telomere length appears to be such a measure. Telomeres, the protective caps at the tips of chromosomes, shorten with age, and this shortening predicts disease and longevity. Leukocyte telomere length may be best viewed through a life-span approach, as it reflects in part the cumulative number of cell divisions that have occurred and the long-term biochemical environment. Recently, a critical mass of studies demonstrated that telomeres appear to shorten with chronic stress, although the mechanisms are unknown. This paper reviews what appear to be malleable determinants of rate of telomere attrition, focusing on early life chronic stressors and metabolic adversity (poor nutrition during development, and obesity). The next generation of research will benefit from experimental and longitudinal models integrating genetic variation, social environments, life experience, and health behaviors. </jats:p> |
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| description | <jats:p> In order to more fully understand associations between psychological stress and health, it is helpful for researchers to identify “psychobiomarkers,” or biological measures that are regulated in part by psychological function and that predict longevity. Telomere length appears to be such a measure. Telomeres, the protective caps at the tips of chromosomes, shorten with age, and this shortening predicts disease and longevity. Leukocyte telomere length may be best viewed through a life-span approach, as it reflects in part the cumulative number of cell divisions that have occurred and the long-term biochemical environment. Recently, a critical mass of studies demonstrated that telomeres appear to shorten with chronic stress, although the mechanisms are unknown. This paper reviews what appear to be malleable determinants of rate of telomere attrition, focusing on early life chronic stressors and metabolic adversity (poor nutrition during development, and obesity). The next generation of research will benefit from experimental and longitudinal models integrating genetic variation, social environments, life experience, and health behaviors. </jats:p> |
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| spelling | Epel, Elissa S. 0963-7214 1467-8721 SAGE Publications General Psychology http://dx.doi.org/10.1111/j.1467-8721.2009.01596.x <jats:p> In order to more fully understand associations between psychological stress and health, it is helpful for researchers to identify “psychobiomarkers,” or biological measures that are regulated in part by psychological function and that predict longevity. Telomere length appears to be such a measure. Telomeres, the protective caps at the tips of chromosomes, shorten with age, and this shortening predicts disease and longevity. Leukocyte telomere length may be best viewed through a life-span approach, as it reflects in part the cumulative number of cell divisions that have occurred and the long-term biochemical environment. Recently, a critical mass of studies demonstrated that telomeres appear to shorten with chronic stress, although the mechanisms are unknown. This paper reviews what appear to be malleable determinants of rate of telomere attrition, focusing on early life chronic stressors and metabolic adversity (poor nutrition during development, and obesity). The next generation of research will benefit from experimental and longitudinal models integrating genetic variation, social environments, life experience, and health behaviors. </jats:p> A New “Psychobiomarker”? Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? Current Directions in Psychological Science |
| spellingShingle | Epel, Elissa S., Current Directions in Psychological Science, Telomeres in a Life-Span Perspective : A New “Psychobiomarker”?, General Psychology |
| title | Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
| title_full | Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
| title_fullStr | Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
| title_full_unstemmed | Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
| title_short | Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
| title_sort | telomeres in a life-span perspective : a new “psychobiomarker”? |
| title_sub | A New “Psychobiomarker”? |
| title_unstemmed | Telomeres in a Life-Span Perspective : A New “Psychobiomarker”? |
| topic | General Psychology |
| url | http://dx.doi.org/10.1111/j.1467-8721.2009.01596.x |