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Patch testing with components of water‐based metalworking fluids
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| Zeitschriftentitel: | Contact Dermatitis |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Contact Dermatitis, 49, 2003, 2, S. 85-90 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Geier, Johannes Lessmann, Holger Frosch, Peter J. Pirker, Claudia Koch, Patrick Aschoff, Roland Richter, Gerhard Becker, Detlef Eckert, Christian Uter, Wolfgang Schnuch, Axel Fuchs, Thomas Geier, Johannes Lessmann, Holger Frosch, Peter J. Pirker, Claudia Koch, Patrick Aschoff, Roland Richter, Gerhard Becker, Detlef Eckert, Christian Uter, Wolfgang Schnuch, Axel Fuchs, Thomas |
|---|---|
| author |
Geier, Johannes Lessmann, Holger Frosch, Peter J. Pirker, Claudia Koch, Patrick Aschoff, Roland Richter, Gerhard Becker, Detlef Eckert, Christian Uter, Wolfgang Schnuch, Axel Fuchs, Thomas |
| spellingShingle |
Geier, Johannes Lessmann, Holger Frosch, Peter J. Pirker, Claudia Koch, Patrick Aschoff, Roland Richter, Gerhard Becker, Detlef Eckert, Christian Uter, Wolfgang Schnuch, Axel Fuchs, Thomas Contact Dermatitis Patch testing with components of water‐based metalworking fluids Dermatology Immunology and Allergy |
| author_sort |
geier, johannes |
| spelling |
Geier, Johannes Lessmann, Holger Frosch, Peter J. Pirker, Claudia Koch, Patrick Aschoff, Roland Richter, Gerhard Becker, Detlef Eckert, Christian Uter, Wolfgang Schnuch, Axel Fuchs, Thomas 0105-1873 1600-0536 Wiley Dermatology Immunology and Allergy http://dx.doi.org/10.1111/j.0105-1873.2003.00187.x <jats:p>Water‐based metalworking fluids (MWFs) may cause both irritant and allergic contact dermatitis. Several well‐known MWF allergens are available for patch testing, but considering the wide variety of possible components used in MWF, our diagnostic arsenal covers only a small part of potential allergens. We therefore selected 13 frequently used MWF components that might be sensitizers and had not yet been tested routinely. In 5 centres, 233 dermatitis patients with present or past occupational exposure to MWF were patch tested with this and other panels. Only 7 patients showed positive reactions to the study panel. Allergic reactions to the emulsifier diglycolamine [syn. 2‐(2‐aminoethoxy) ethanol] were seen in 5 patients, and 1 patient each reacted positively to 2‐amino‐2‐ethyl‐1,3‐propanediol (AEPD) and methyldiethanolamine (MDEA). Clinical relevance of the reactions to diglycolamine was unequivocally proven by its presence in the MWF from the patients' workplace in 3 cases. Diglycolamine seems to be an important MWF allergen, independently from monoethanolamine and diethanolamine. A test concentration of 1% petrolatum (pet.) appears to be appropriate. The importance of AEPD and MDEA as MWF allergens still remains to be established. The lack of positive test reactions to the other MWF components tested may be due to their low‐sensitizing potential or too low a patch test concentration being used.</jats:p> Patch testing with components of water‐based metalworking fluids Contact Dermatitis |
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| title |
Patch testing with components of water‐based metalworking fluids |
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Patch testing with components of water‐based metalworking fluids |
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Patch testing with components of water‐based metalworking fluids |
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Patch testing with components of water‐based metalworking fluids |
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Patch testing with components of water‐based metalworking fluids |
| title_short |
Patch testing with components of water‐based metalworking fluids |
| title_sort |
patch testing with components of water‐based metalworking fluids |
| topic |
Dermatology Immunology and Allergy |
| url |
http://dx.doi.org/10.1111/j.0105-1873.2003.00187.x |
| publishDate |
2003 |
| physical |
85-90 |
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<jats:p>Water‐based metalworking fluids (MWFs) may cause both irritant and allergic contact dermatitis. Several well‐known MWF allergens are available for patch testing, but considering the wide variety of possible components used in MWF, our diagnostic arsenal covers only a small part of potential allergens. We therefore selected 13 frequently used MWF components that might be sensitizers and had not yet been tested routinely. In 5 centres, 233 dermatitis patients with present or past occupational exposure to MWF were patch tested with this and other panels. Only 7 patients showed positive reactions to the study panel. Allergic reactions to the emulsifier diglycolamine [syn. 2‐(2‐aminoethoxy) ethanol] were seen in 5 patients, and 1 patient each reacted positively to 2‐amino‐2‐ethyl‐1,3‐propanediol (AEPD) and methyldiethanolamine (MDEA). Clinical relevance of the reactions to diglycolamine was unequivocally proven by its presence in the MWF from the patients' workplace in 3 cases. Diglycolamine seems to be an important MWF allergen, independently from monoethanolamine and diethanolamine. A test concentration of 1% petrolatum (pet.) appears to be appropriate. The importance of AEPD and MDEA as MWF allergens still remains to be established. The lack of positive test reactions to the other MWF components tested may be due to their low‐sensitizing potential or too low a patch test concentration being used.</jats:p> |
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| author | Geier, Johannes, Lessmann, Holger, Frosch, Peter J., Pirker, Claudia, Koch, Patrick, Aschoff, Roland, Richter, Gerhard, Becker, Detlef, Eckert, Christian, Uter, Wolfgang, Schnuch, Axel, Fuchs, Thomas |
| author_facet | Geier, Johannes, Lessmann, Holger, Frosch, Peter J., Pirker, Claudia, Koch, Patrick, Aschoff, Roland, Richter, Gerhard, Becker, Detlef, Eckert, Christian, Uter, Wolfgang, Schnuch, Axel, Fuchs, Thomas, Geier, Johannes, Lessmann, Holger, Frosch, Peter J., Pirker, Claudia, Koch, Patrick, Aschoff, Roland, Richter, Gerhard, Becker, Detlef, Eckert, Christian, Uter, Wolfgang, Schnuch, Axel, Fuchs, Thomas |
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| description | <jats:p>Water‐based metalworking fluids (MWFs) may cause both irritant and allergic contact dermatitis. Several well‐known MWF allergens are available for patch testing, but considering the wide variety of possible components used in MWF, our diagnostic arsenal covers only a small part of potential allergens. We therefore selected 13 frequently used MWF components that might be sensitizers and had not yet been tested routinely. In 5 centres, 233 dermatitis patients with present or past occupational exposure to MWF were patch tested with this and other panels. Only 7 patients showed positive reactions to the study panel. Allergic reactions to the emulsifier diglycolamine [syn. 2‐(2‐aminoethoxy) ethanol] were seen in 5 patients, and 1 patient each reacted positively to 2‐amino‐2‐ethyl‐1,3‐propanediol (AEPD) and methyldiethanolamine (MDEA). Clinical relevance of the reactions to diglycolamine was unequivocally proven by its presence in the MWF from the patients' workplace in 3 cases. Diglycolamine seems to be an important MWF allergen, independently from monoethanolamine and diethanolamine. A test concentration of 1% petrolatum (pet.) appears to be appropriate. The importance of AEPD and MDEA as MWF allergens still remains to be established. The lack of positive test reactions to the other MWF components tested may be due to their low‐sensitizing potential or too low a patch test concentration being used.</jats:p> |
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| spelling | Geier, Johannes Lessmann, Holger Frosch, Peter J. Pirker, Claudia Koch, Patrick Aschoff, Roland Richter, Gerhard Becker, Detlef Eckert, Christian Uter, Wolfgang Schnuch, Axel Fuchs, Thomas 0105-1873 1600-0536 Wiley Dermatology Immunology and Allergy http://dx.doi.org/10.1111/j.0105-1873.2003.00187.x <jats:p>Water‐based metalworking fluids (MWFs) may cause both irritant and allergic contact dermatitis. Several well‐known MWF allergens are available for patch testing, but considering the wide variety of possible components used in MWF, our diagnostic arsenal covers only a small part of potential allergens. We therefore selected 13 frequently used MWF components that might be sensitizers and had not yet been tested routinely. In 5 centres, 233 dermatitis patients with present or past occupational exposure to MWF were patch tested with this and other panels. Only 7 patients showed positive reactions to the study panel. Allergic reactions to the emulsifier diglycolamine [syn. 2‐(2‐aminoethoxy) ethanol] were seen in 5 patients, and 1 patient each reacted positively to 2‐amino‐2‐ethyl‐1,3‐propanediol (AEPD) and methyldiethanolamine (MDEA). Clinical relevance of the reactions to diglycolamine was unequivocally proven by its presence in the MWF from the patients' workplace in 3 cases. Diglycolamine seems to be an important MWF allergen, independently from monoethanolamine and diethanolamine. A test concentration of 1% petrolatum (pet.) appears to be appropriate. The importance of AEPD and MDEA as MWF allergens still remains to be established. The lack of positive test reactions to the other MWF components tested may be due to their low‐sensitizing potential or too low a patch test concentration being used.</jats:p> Patch testing with components of water‐based metalworking fluids Contact Dermatitis |
| spellingShingle | Geier, Johannes, Lessmann, Holger, Frosch, Peter J., Pirker, Claudia, Koch, Patrick, Aschoff, Roland, Richter, Gerhard, Becker, Detlef, Eckert, Christian, Uter, Wolfgang, Schnuch, Axel, Fuchs, Thomas, Contact Dermatitis, Patch testing with components of water‐based metalworking fluids, Dermatology, Immunology and Allergy |
| title | Patch testing with components of water‐based metalworking fluids |
| title_full | Patch testing with components of water‐based metalworking fluids |
| title_fullStr | Patch testing with components of water‐based metalworking fluids |
| title_full_unstemmed | Patch testing with components of water‐based metalworking fluids |
| title_short | Patch testing with components of water‐based metalworking fluids |
| title_sort | patch testing with components of water‐based metalworking fluids |
| title_unstemmed | Patch testing with components of water‐based metalworking fluids |
| topic | Dermatology, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/j.0105-1873.2003.00187.x |