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The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition
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| Zeitschriftentitel: | Immunology & Cell Biology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , |
| In: | Immunology & Cell Biology, 96, 2018, 1, S. 81-99 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Bardet, Maureen Unterreiner, Adeline Malinverni, Claire Lafossas, Frédérique Vedrine, Corinne Boesch, Danielle Kolb, Yeter Kaiser, Daniel Glück, Anton Schneider, Martin A Katopodis, Andreas Renatus, Martin Simic, Oliver Schlapbach, Achim Quancard, Jean Régnier, Catherine H Bold, Guido Pissot‐Soldermann, Carole Carballido, José M Kovarik, Jiri Calzascia, Thomas Bornancin, Frédéric Bardet, Maureen Unterreiner, Adeline Malinverni, Claire Lafossas, Frédérique Vedrine, Corinne Boesch, Danielle Kolb, Yeter Kaiser, Daniel Glück, Anton Schneider, Martin A Katopodis, Andreas Renatus, Martin Simic, Oliver Schlapbach, Achim Quancard, Jean Régnier, Catherine H Bold, Guido Pissot‐Soldermann, Carole Carballido, José M Kovarik, Jiri Calzascia, Thomas Bornancin, Frédéric |
|---|---|
| author |
Bardet, Maureen Unterreiner, Adeline Malinverni, Claire Lafossas, Frédérique Vedrine, Corinne Boesch, Danielle Kolb, Yeter Kaiser, Daniel Glück, Anton Schneider, Martin A Katopodis, Andreas Renatus, Martin Simic, Oliver Schlapbach, Achim Quancard, Jean Régnier, Catherine H Bold, Guido Pissot‐Soldermann, Carole Carballido, José M Kovarik, Jiri Calzascia, Thomas Bornancin, Frédéric |
| spellingShingle |
Bardet, Maureen Unterreiner, Adeline Malinverni, Claire Lafossas, Frédérique Vedrine, Corinne Boesch, Danielle Kolb, Yeter Kaiser, Daniel Glück, Anton Schneider, Martin A Katopodis, Andreas Renatus, Martin Simic, Oliver Schlapbach, Achim Quancard, Jean Régnier, Catherine H Bold, Guido Pissot‐Soldermann, Carole Carballido, José M Kovarik, Jiri Calzascia, Thomas Bornancin, Frédéric Immunology & Cell Biology The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition Cell Biology Immunology Immunology and Allergy |
| author_sort |
bardet, maureen |
| spelling |
Bardet, Maureen Unterreiner, Adeline Malinverni, Claire Lafossas, Frédérique Vedrine, Corinne Boesch, Danielle Kolb, Yeter Kaiser, Daniel Glück, Anton Schneider, Martin A Katopodis, Andreas Renatus, Martin Simic, Oliver Schlapbach, Achim Quancard, Jean Régnier, Catherine H Bold, Guido Pissot‐Soldermann, Carole Carballido, José M Kovarik, Jiri Calzascia, Thomas Bornancin, Frédéric 0818-9641 1440-1711 Wiley Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1111/imcb.1018 <jats:title>Abstract</jats:title><jats:p>Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is essential for immune responses triggered by antigen receptors but the contribution of its paracaspase activity is not fully understood. Here, we studied how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 proteolytic function regulates T‐cell activation and fate after engagement of the T‐cell receptor pathway. We show that <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827, a potent and selective <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase inhibitor, does not prevent the initial phase of T‐cell activation, in contrast to the pan‐protein kinase C inhibitor <jats:styled-content style="fixed-case">AEB</jats:styled-content>071. However, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 strongly impacted cell expansion after activation. We demonstrate this is the consequence of profound inhibition of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 production as well as reduced expression of the <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 receptor alpha subunit (<jats:styled-content style="fixed-case">CD</jats:styled-content>25), resulting from defective canonical <jats:styled-content style="fixed-case">NF</jats:styled-content>‐κB activation and accelerated <jats:styled-content style="fixed-case">mRNA</jats:styled-content> turnover mechanisms. Accordingly, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 revealed a unique transcriptional fingerprint of <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 protease activity, providing evidence for broad control of T‐cell signaling pathways. Altogether, this first report with a potent and selective inhibitor elucidates how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase activity integrates several T‐cell activation pathways and indirectly controls gamma‐chain receptor dependent survival, to impact on T‐cell expansion.</jats:p> The T‐cell fingerprint of <scp>MALT</scp>1 paracaspase revealed by selective inhibition Immunology & Cell Biology |
| doi_str_mv |
10.1111/imcb.1018 |
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Online |
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Biologie Medizin |
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Wiley, 2018 |
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Immunology & Cell Biology |
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| title |
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_unstemmed |
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_full |
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_fullStr |
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_full_unstemmed |
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_short |
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_sort |
the t‐cell fingerprint of <scp>malt</scp>1 paracaspase revealed by selective inhibition |
| topic |
Cell Biology Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1111/imcb.1018 |
| publishDate |
2018 |
| physical |
81-99 |
| description |
<jats:title>Abstract</jats:title><jats:p>Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is essential for immune responses triggered by antigen receptors but the contribution of its paracaspase activity is not fully understood. Here, we studied how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 proteolytic function regulates T‐cell activation and fate after engagement of the T‐cell receptor pathway. We show that <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827, a potent and selective <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase inhibitor, does not prevent the initial phase of T‐cell activation, in contrast to the pan‐protein kinase C inhibitor <jats:styled-content style="fixed-case">AEB</jats:styled-content>071. However, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 strongly impacted cell expansion after activation. We demonstrate this is the consequence of profound inhibition of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 production as well as reduced expression of the <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 receptor alpha subunit (<jats:styled-content style="fixed-case">CD</jats:styled-content>25), resulting from defective canonical <jats:styled-content style="fixed-case">NF</jats:styled-content>‐κB activation and accelerated <jats:styled-content style="fixed-case">mRNA</jats:styled-content> turnover mechanisms. Accordingly, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 revealed a unique transcriptional fingerprint of <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 protease activity, providing evidence for broad control of T‐cell signaling pathways. Altogether, this first report with a potent and selective inhibitor elucidates how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase activity integrates several T‐cell activation pathways and indirectly controls gamma‐chain receptor dependent survival, to impact on T‐cell expansion.</jats:p> |
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| author | Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric |
| author_facet | Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric, Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric |
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| description | <jats:title>Abstract</jats:title><jats:p>Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is essential for immune responses triggered by antigen receptors but the contribution of its paracaspase activity is not fully understood. Here, we studied how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 proteolytic function regulates T‐cell activation and fate after engagement of the T‐cell receptor pathway. We show that <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827, a potent and selective <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase inhibitor, does not prevent the initial phase of T‐cell activation, in contrast to the pan‐protein kinase C inhibitor <jats:styled-content style="fixed-case">AEB</jats:styled-content>071. However, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 strongly impacted cell expansion after activation. We demonstrate this is the consequence of profound inhibition of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 production as well as reduced expression of the <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 receptor alpha subunit (<jats:styled-content style="fixed-case">CD</jats:styled-content>25), resulting from defective canonical <jats:styled-content style="fixed-case">NF</jats:styled-content>‐κB activation and accelerated <jats:styled-content style="fixed-case">mRNA</jats:styled-content> turnover mechanisms. Accordingly, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 revealed a unique transcriptional fingerprint of <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 protease activity, providing evidence for broad control of T‐cell signaling pathways. Altogether, this first report with a potent and selective inhibitor elucidates how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase activity integrates several T‐cell activation pathways and indirectly controls gamma‐chain receptor dependent survival, to impact on T‐cell expansion.</jats:p> |
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| imprint_str_mv | Wiley, 2018 |
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| spelling | Bardet, Maureen Unterreiner, Adeline Malinverni, Claire Lafossas, Frédérique Vedrine, Corinne Boesch, Danielle Kolb, Yeter Kaiser, Daniel Glück, Anton Schneider, Martin A Katopodis, Andreas Renatus, Martin Simic, Oliver Schlapbach, Achim Quancard, Jean Régnier, Catherine H Bold, Guido Pissot‐Soldermann, Carole Carballido, José M Kovarik, Jiri Calzascia, Thomas Bornancin, Frédéric 0818-9641 1440-1711 Wiley Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1111/imcb.1018 <jats:title>Abstract</jats:title><jats:p>Mucosa‐associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is essential for immune responses triggered by antigen receptors but the contribution of its paracaspase activity is not fully understood. Here, we studied how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 proteolytic function regulates T‐cell activation and fate after engagement of the T‐cell receptor pathway. We show that <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827, a potent and selective <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase inhibitor, does not prevent the initial phase of T‐cell activation, in contrast to the pan‐protein kinase C inhibitor <jats:styled-content style="fixed-case">AEB</jats:styled-content>071. However, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 strongly impacted cell expansion after activation. We demonstrate this is the consequence of profound inhibition of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 production as well as reduced expression of the <jats:styled-content style="fixed-case">IL</jats:styled-content>‐2 receptor alpha subunit (<jats:styled-content style="fixed-case">CD</jats:styled-content>25), resulting from defective canonical <jats:styled-content style="fixed-case">NF</jats:styled-content>‐κB activation and accelerated <jats:styled-content style="fixed-case">mRNA</jats:styled-content> turnover mechanisms. Accordingly, <jats:styled-content style="fixed-case">MLT</jats:styled-content>‐827 revealed a unique transcriptional fingerprint of <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 protease activity, providing evidence for broad control of T‐cell signaling pathways. Altogether, this first report with a potent and selective inhibitor elucidates how <jats:styled-content style="fixed-case">MALT</jats:styled-content>1 paracaspase activity integrates several T‐cell activation pathways and indirectly controls gamma‐chain receptor dependent survival, to impact on T‐cell expansion.</jats:p> The T‐cell fingerprint of <scp>MALT</scp>1 paracaspase revealed by selective inhibition Immunology & Cell Biology |
| spellingShingle | Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric, Immunology & Cell Biology, The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition, Cell Biology, Immunology, Immunology and Allergy |
| title | The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_full | The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_fullStr | The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_full_unstemmed | The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_short | The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| title_sort | the t‐cell fingerprint of <scp>malt</scp>1 paracaspase revealed by selective inhibition |
| title_unstemmed | The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition |
| topic | Cell Biology, Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/imcb.1018 |