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Oligodendrocyte‐microglia cross‐talk in the central nervous system
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| Zeitschriftentitel: | Immunology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Immunology, 141, 2014, 3, S. 302-313 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Peferoen, Laura Kipp, Markus van der Valk, Paul van Noort, Johannes M. Amor, Sandra Peferoen, Laura Kipp, Markus van der Valk, Paul van Noort, Johannes M. Amor, Sandra |
|---|---|
| author |
Peferoen, Laura Kipp, Markus van der Valk, Paul van Noort, Johannes M. Amor, Sandra |
| spellingShingle |
Peferoen, Laura Kipp, Markus van der Valk, Paul van Noort, Johannes M. Amor, Sandra Immunology Oligodendrocyte‐microglia cross‐talk in the central nervous system Immunology Immunology and Allergy |
| author_sort |
peferoen, laura |
| spelling |
Peferoen, Laura Kipp, Markus van der Valk, Paul van Noort, Johannes M. Amor, Sandra 0019-2805 1365-2567 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1111/imm.12163 <jats:title>Summary</jats:title><jats:p>Communication between the immune system and the central nervous system (<jats:styled-content style="fixed-case">CNS</jats:styled-content>) is exemplified by cross‐talk between glia and neurons shown to be essential for maintaining homeostasis. While microglia are actively modulated by neurons in the healthy brain, little is known about the cross‐talk between oligodendrocytes and microglia. Oligodendrocytes, the myelin‐forming cells in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>, are essential for the propagation of action potentials along axons, and additionally serve to support neurons by producing neurotrophic factors. In demyelinating diseases such as multiple sclerosis, oligodendrocytes are thought to be the victims. Here, we review evidence that oligodendrocytes also have strong immune functions, express a wide variety of innate immune receptors, and produce and respond to chemokines and cytokines that modulate immune responses in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>. We also review evidence that during stress events in the brain, oligodendrocytes can trigger a cascade of protective and regenerative responses, in addition to responses that elicit progressive neurodegeneration. Knowledge of the cross‐talk between microglia and oligodendrocytes may continue to uncover novel pathways of immune regulation in the brain that could be further exploited to control neuroinflammation and degeneration.</jats:p> Oligodendrocyte‐microglia cross‐talk in the central nervous system Immunology |
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10.1111/imm.12163 |
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Online Free |
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Medizin |
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Wiley, 2014 |
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Wiley, 2014 |
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0019-2805 1365-2567 |
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Immunology |
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| title |
Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_unstemmed |
Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_full |
Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_fullStr |
Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_full_unstemmed |
Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_short |
Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_sort |
oligodendrocyte‐microglia cross‐talk in the central nervous system |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1111/imm.12163 |
| publishDate |
2014 |
| physical |
302-313 |
| description |
<jats:title>Summary</jats:title><jats:p>Communication between the immune system and the central nervous system (<jats:styled-content style="fixed-case">CNS</jats:styled-content>) is exemplified by cross‐talk between glia and neurons shown to be essential for maintaining homeostasis. While microglia are actively modulated by neurons in the healthy brain, little is known about the cross‐talk between oligodendrocytes and microglia. Oligodendrocytes, the myelin‐forming cells in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>, are essential for the propagation of action potentials along axons, and additionally serve to support neurons by producing neurotrophic factors. In demyelinating diseases such as multiple sclerosis, oligodendrocytes are thought to be the victims. Here, we review evidence that oligodendrocytes also have strong immune functions, express a wide variety of innate immune receptors, and produce and respond to chemokines and cytokines that modulate immune responses in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>. We also review evidence that during stress events in the brain, oligodendrocytes can trigger a cascade of protective and regenerative responses, in addition to responses that elicit progressive neurodegeneration. Knowledge of the cross‐talk between microglia and oligodendrocytes may continue to uncover novel pathways of immune regulation in the brain that could be further exploited to control neuroinflammation and degeneration.</jats:p> |
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| author | Peferoen, Laura, Kipp, Markus, van der Valk, Paul, van Noort, Johannes M., Amor, Sandra |
| author_facet | Peferoen, Laura, Kipp, Markus, van der Valk, Paul, van Noort, Johannes M., Amor, Sandra, Peferoen, Laura, Kipp, Markus, van der Valk, Paul, van Noort, Johannes M., Amor, Sandra |
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| description | <jats:title>Summary</jats:title><jats:p>Communication between the immune system and the central nervous system (<jats:styled-content style="fixed-case">CNS</jats:styled-content>) is exemplified by cross‐talk between glia and neurons shown to be essential for maintaining homeostasis. While microglia are actively modulated by neurons in the healthy brain, little is known about the cross‐talk between oligodendrocytes and microglia. Oligodendrocytes, the myelin‐forming cells in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>, are essential for the propagation of action potentials along axons, and additionally serve to support neurons by producing neurotrophic factors. In demyelinating diseases such as multiple sclerosis, oligodendrocytes are thought to be the victims. Here, we review evidence that oligodendrocytes also have strong immune functions, express a wide variety of innate immune receptors, and produce and respond to chemokines and cytokines that modulate immune responses in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>. We also review evidence that during stress events in the brain, oligodendrocytes can trigger a cascade of protective and regenerative responses, in addition to responses that elicit progressive neurodegeneration. Knowledge of the cross‐talk between microglia and oligodendrocytes may continue to uncover novel pathways of immune regulation in the brain that could be further exploited to control neuroinflammation and degeneration.</jats:p> |
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| spelling | Peferoen, Laura Kipp, Markus van der Valk, Paul van Noort, Johannes M. Amor, Sandra 0019-2805 1365-2567 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1111/imm.12163 <jats:title>Summary</jats:title><jats:p>Communication between the immune system and the central nervous system (<jats:styled-content style="fixed-case">CNS</jats:styled-content>) is exemplified by cross‐talk between glia and neurons shown to be essential for maintaining homeostasis. While microglia are actively modulated by neurons in the healthy brain, little is known about the cross‐talk between oligodendrocytes and microglia. Oligodendrocytes, the myelin‐forming cells in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>, are essential for the propagation of action potentials along axons, and additionally serve to support neurons by producing neurotrophic factors. In demyelinating diseases such as multiple sclerosis, oligodendrocytes are thought to be the victims. Here, we review evidence that oligodendrocytes also have strong immune functions, express a wide variety of innate immune receptors, and produce and respond to chemokines and cytokines that modulate immune responses in the <jats:styled-content style="fixed-case">CNS</jats:styled-content>. We also review evidence that during stress events in the brain, oligodendrocytes can trigger a cascade of protective and regenerative responses, in addition to responses that elicit progressive neurodegeneration. Knowledge of the cross‐talk between microglia and oligodendrocytes may continue to uncover novel pathways of immune regulation in the brain that could be further exploited to control neuroinflammation and degeneration.</jats:p> Oligodendrocyte‐microglia cross‐talk in the central nervous system Immunology |
| spellingShingle | Peferoen, Laura, Kipp, Markus, van der Valk, Paul, van Noort, Johannes M., Amor, Sandra, Immunology, Oligodendrocyte‐microglia cross‐talk in the central nervous system, Immunology, Immunology and Allergy |
| title | Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_full | Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_fullStr | Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_full_unstemmed | Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_short | Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_sort | oligodendrocyte‐microglia cross‐talk in the central nervous system |
| title_unstemmed | Oligodendrocyte‐microglia cross‐talk in the central nervous system |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/imm.12163 |