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The life (and death) of CD4+CD28null T cells in inflammatory diseases
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| Zeitschriftentitel: | Immunology |
|---|---|
| Personen und Körperschaften: | |
| In: | Immunology, 146, 2015, 2, S. 185-193 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Dumitriu, Ingrid E. Dumitriu, Ingrid E. |
|---|---|
| author |
Dumitriu, Ingrid E. |
| spellingShingle |
Dumitriu, Ingrid E. Immunology The life (and death) of CD4+CD28null T cells in inflammatory diseases Immunology Immunology and Allergy |
| author_sort |
dumitriu, ingrid e. |
| spelling |
Dumitriu, Ingrid E. 0019-2805 1365-2567 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1111/imm.12506 <jats:title>Summary</jats:title><jats:p>Inflammation contributes to the development and perpetuation of several disorders and T lymphocytes orchestrate the inflammatory immune response. Although the role of T cells in inflammation is widely recognized, specific therapies that tackle inflammatory networks in disease are yet to be developed. <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells are a unique subset of helper T lymphocytes that recently shot back into the limelight as potential catalysts of inflammation in several inflammatory disorders such as autoimmunity, atherosclerosis and chronic viral infections. In contrast to conventional helper T cells, <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells have an inbuilt ability to release inflammatory cytokines and cytotoxic molecules that can damage tissues and amplify inflammatory pathways. It comes as no surprise that patients who have high numbers of these cells have more severe disease and poor prognosis. In this review, I provide an overview on the latest advances in the biology of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells. Understanding the complex functions and dynamics of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells may open new avenues for therapeutic intervention to prevent progression of inflammatory diseases.</jats:p> The life (and death) of <scp>CD</scp>4<sup>+</sup><scp>CD</scp>28<sup>null</sup> T cells in inflammatory diseases Immunology |
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10.1111/imm.12506 |
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Wiley, 2015 |
| imprint_str_mv |
Wiley, 2015 |
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Immunology |
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| title |
The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_unstemmed |
The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_full |
The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_fullStr |
The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_full_unstemmed |
The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_short |
The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_sort |
the life (and death) of <scp>cd</scp>4<sup>+</sup><scp>cd</scp>28<sup>null</sup> t cells in inflammatory diseases |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1111/imm.12506 |
| publishDate |
2015 |
| physical |
185-193 |
| description |
<jats:title>Summary</jats:title><jats:p>Inflammation contributes to the development and perpetuation of several disorders and T lymphocytes orchestrate the inflammatory immune response. Although the role of T cells in inflammation is widely recognized, specific therapies that tackle inflammatory networks in disease are yet to be developed. <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells are a unique subset of helper T lymphocytes that recently shot back into the limelight as potential catalysts of inflammation in several inflammatory disorders such as autoimmunity, atherosclerosis and chronic viral infections. In contrast to conventional helper T cells, <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells have an inbuilt ability to release inflammatory cytokines and cytotoxic molecules that can damage tissues and amplify inflammatory pathways. It comes as no surprise that patients who have high numbers of these cells have more severe disease and poor prognosis. In this review, I provide an overview on the latest advances in the biology of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells. Understanding the complex functions and dynamics of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells may open new avenues for therapeutic intervention to prevent progression of inflammatory diseases.</jats:p> |
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| description | <jats:title>Summary</jats:title><jats:p>Inflammation contributes to the development and perpetuation of several disorders and T lymphocytes orchestrate the inflammatory immune response. Although the role of T cells in inflammation is widely recognized, specific therapies that tackle inflammatory networks in disease are yet to be developed. <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells are a unique subset of helper T lymphocytes that recently shot back into the limelight as potential catalysts of inflammation in several inflammatory disorders such as autoimmunity, atherosclerosis and chronic viral infections. In contrast to conventional helper T cells, <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells have an inbuilt ability to release inflammatory cytokines and cytotoxic molecules that can damage tissues and amplify inflammatory pathways. It comes as no surprise that patients who have high numbers of these cells have more severe disease and poor prognosis. In this review, I provide an overview on the latest advances in the biology of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells. Understanding the complex functions and dynamics of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells may open new avenues for therapeutic intervention to prevent progression of inflammatory diseases.</jats:p> |
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| spelling | Dumitriu, Ingrid E. 0019-2805 1365-2567 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1111/imm.12506 <jats:title>Summary</jats:title><jats:p>Inflammation contributes to the development and perpetuation of several disorders and T lymphocytes orchestrate the inflammatory immune response. Although the role of T cells in inflammation is widely recognized, specific therapies that tackle inflammatory networks in disease are yet to be developed. <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells are a unique subset of helper T lymphocytes that recently shot back into the limelight as potential catalysts of inflammation in several inflammatory disorders such as autoimmunity, atherosclerosis and chronic viral infections. In contrast to conventional helper T cells, <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells have an inbuilt ability to release inflammatory cytokines and cytotoxic molecules that can damage tissues and amplify inflammatory pathways. It comes as no surprise that patients who have high numbers of these cells have more severe disease and poor prognosis. In this review, I provide an overview on the latest advances in the biology of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells. Understanding the complex functions and dynamics of <jats:styled-content style="fixed-case">CD</jats:styled-content>4<jats:sup>+</jats:sup><jats:styled-content style="fixed-case">CD</jats:styled-content>28<jats:sup>null</jats:sup> T cells may open new avenues for therapeutic intervention to prevent progression of inflammatory diseases.</jats:p> The life (and death) of <scp>CD</scp>4<sup>+</sup><scp>CD</scp>28<sup>null</sup> T cells in inflammatory diseases Immunology |
| spellingShingle | Dumitriu, Ingrid E., Immunology, The life (and death) of CD4+CD28null T cells in inflammatory diseases, Immunology, Immunology and Allergy |
| title | The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_full | The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_fullStr | The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_full_unstemmed | The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_short | The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| title_sort | the life (and death) of <scp>cd</scp>4<sup>+</sup><scp>cd</scp>28<sup>null</sup> t cells in inflammatory diseases |
| title_unstemmed | The life (and death) of CD4+CD28null T cells in inflammatory diseases |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/imm.12506 |