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Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count?
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| Zeitschriftentitel: | International Journal of Laboratory Hematology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | International Journal of Laboratory Hematology, 40, 2018, 4, S. 488-492 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Li, X. Li, W. Luo, Y. Qin, L. Su, Q. Mo, W. Li, X. Li, W. Luo, Y. Qin, L. Su, Q. Mo, W. |
|---|---|
| author |
Li, X. Li, W. Luo, Y. Qin, L. Su, Q. Mo, W. |
| spellingShingle |
Li, X. Li, W. Luo, Y. Qin, L. Su, Q. Mo, W. International Journal of Laboratory Hematology Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? Biochemistry (medical) Clinical Biochemistry Hematology General Medicine |
| author_sort |
li, x. |
| spelling |
Li, X. Li, W. Luo, Y. Qin, L. Su, Q. Mo, W. 1751-5521 1751-553X Wiley Biochemistry (medical) Clinical Biochemistry Hematology General Medicine http://dx.doi.org/10.1111/ijlh.12845 <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Guillain‐Barré syndrome (<jats:styled-content style="fixed-case">GBS</jats:styled-content>) is an inflammatory demyelinating autoimmune disease, associated with blood‐nerve barrier breakdown, inflammatory cells infiltration, and cytokine leakage in the peripheral nervous system. Currently, it has been revealed that monocytes play key roles in the inflammatory response. Therefore, we aimed to assess the correlation between monocyte count and <jats:styled-content style="fixed-case">GBS</jats:styled-content> in this study.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Retrospective study was conducted in 114 patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> and 120 age‐ and gender‐matched individuals.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Absolute monocyte count in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> was higher than that in healthy controls (0.61 ± 0.24 vs 0.41 ± 0.10; <jats:italic>P</jats:italic> < .001). Interestingly, monocyte count had significant positive correlations with <jats:styled-content style="fixed-case">CRP</jats:styled-content>,<jats:styled-content style="fixed-case"> ESR</jats:styled-content>, and disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content> (<jats:italic>r</jats:italic> = .244, <jats:italic>P</jats:italic> = .009; <jats:italic>r</jats:italic> = .269, <jats:italic>P</jats:italic> = .004; <jats:italic>r</jats:italic> = .322, <jats:italic>P</jats:italic> < .001). A cutoff value of 0.515 for monocyte count was observed in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> (areas under the curve = 0.808, 95% confidence interval = 0.749‐0.868, <jats:italic>P</jats:italic> < .001). Meanwhile, absolute monocyte count was independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> in logistic regression analysis (odds ratio = 2.291, 95% confidence interval = 3.557‐27.493, <jats:italic>P</jats:italic> < .001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings demonstrated that elevated monocyte count is independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> patients, and suggested monocyte count is positively associated with disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content>.</jats:p></jats:sec> Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? International Journal of Laboratory Hematology |
| doi_str_mv |
10.1111/ijlh.12845 |
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Online |
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Medizin Biologie Chemie und Pharmazie |
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| imprint |
Wiley, 2018 |
| imprint_str_mv |
Wiley, 2018 |
| issn |
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2018 |
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Wiley |
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International Journal of Laboratory Hematology |
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49 |
| title |
Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_unstemmed |
Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_full |
Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_fullStr |
Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_full_unstemmed |
Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_short |
Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_sort |
can we assess severity of guillain‐barré syndrome using absolute monocyte count? |
| topic |
Biochemistry (medical) Clinical Biochemistry Hematology General Medicine |
| url |
http://dx.doi.org/10.1111/ijlh.12845 |
| publishDate |
2018 |
| physical |
488-492 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Guillain‐Barré syndrome (<jats:styled-content style="fixed-case">GBS</jats:styled-content>) is an inflammatory demyelinating autoimmune disease, associated with blood‐nerve barrier breakdown, inflammatory cells infiltration, and cytokine leakage in the peripheral nervous system. Currently, it has been revealed that monocytes play key roles in the inflammatory response. Therefore, we aimed to assess the correlation between monocyte count and <jats:styled-content style="fixed-case">GBS</jats:styled-content> in this study.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Retrospective study was conducted in 114 patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> and 120 age‐ and gender‐matched individuals.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Absolute monocyte count in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> was higher than that in healthy controls (0.61 ± 0.24 vs 0.41 ± 0.10; <jats:italic>P</jats:italic> < .001). Interestingly, monocyte count had significant positive correlations with <jats:styled-content style="fixed-case">CRP</jats:styled-content>,<jats:styled-content style="fixed-case"> ESR</jats:styled-content>, and disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content> (<jats:italic>r</jats:italic> = .244, <jats:italic>P</jats:italic> = .009; <jats:italic>r</jats:italic> = .269, <jats:italic>P</jats:italic> = .004; <jats:italic>r</jats:italic> = .322, <jats:italic>P</jats:italic> < .001). A cutoff value of 0.515 for monocyte count was observed in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> (areas under the curve = 0.808, 95% confidence interval = 0.749‐0.868, <jats:italic>P</jats:italic> < .001). Meanwhile, absolute monocyte count was independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> in logistic regression analysis (odds ratio = 2.291, 95% confidence interval = 3.557‐27.493, <jats:italic>P</jats:italic> < .001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings demonstrated that elevated monocyte count is independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> patients, and suggested monocyte count is positively associated with disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content>.</jats:p></jats:sec> |
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| author | Li, X., Li, W., Luo, Y., Qin, L., Su, Q., Mo, W. |
| author_facet | Li, X., Li, W., Luo, Y., Qin, L., Su, Q., Mo, W., Li, X., Li, W., Luo, Y., Qin, L., Su, Q., Mo, W. |
| author_sort | li, x. |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Guillain‐Barré syndrome (<jats:styled-content style="fixed-case">GBS</jats:styled-content>) is an inflammatory demyelinating autoimmune disease, associated with blood‐nerve barrier breakdown, inflammatory cells infiltration, and cytokine leakage in the peripheral nervous system. Currently, it has been revealed that monocytes play key roles in the inflammatory response. Therefore, we aimed to assess the correlation between monocyte count and <jats:styled-content style="fixed-case">GBS</jats:styled-content> in this study.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Retrospective study was conducted in 114 patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> and 120 age‐ and gender‐matched individuals.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Absolute monocyte count in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> was higher than that in healthy controls (0.61 ± 0.24 vs 0.41 ± 0.10; <jats:italic>P</jats:italic> < .001). Interestingly, monocyte count had significant positive correlations with <jats:styled-content style="fixed-case">CRP</jats:styled-content>,<jats:styled-content style="fixed-case"> ESR</jats:styled-content>, and disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content> (<jats:italic>r</jats:italic> = .244, <jats:italic>P</jats:italic> = .009; <jats:italic>r</jats:italic> = .269, <jats:italic>P</jats:italic> = .004; <jats:italic>r</jats:italic> = .322, <jats:italic>P</jats:italic> < .001). A cutoff value of 0.515 for monocyte count was observed in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> (areas under the curve = 0.808, 95% confidence interval = 0.749‐0.868, <jats:italic>P</jats:italic> < .001). Meanwhile, absolute monocyte count was independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> in logistic regression analysis (odds ratio = 2.291, 95% confidence interval = 3.557‐27.493, <jats:italic>P</jats:italic> < .001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings demonstrated that elevated monocyte count is independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> patients, and suggested monocyte count is positively associated with disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content>.</jats:p></jats:sec> |
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| imprint | Wiley, 2018 |
| imprint_str_mv | Wiley, 2018 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Li, X. Li, W. Luo, Y. Qin, L. Su, Q. Mo, W. 1751-5521 1751-553X Wiley Biochemistry (medical) Clinical Biochemistry Hematology General Medicine http://dx.doi.org/10.1111/ijlh.12845 <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>Guillain‐Barré syndrome (<jats:styled-content style="fixed-case">GBS</jats:styled-content>) is an inflammatory demyelinating autoimmune disease, associated with blood‐nerve barrier breakdown, inflammatory cells infiltration, and cytokine leakage in the peripheral nervous system. Currently, it has been revealed that monocytes play key roles in the inflammatory response. Therefore, we aimed to assess the correlation between monocyte count and <jats:styled-content style="fixed-case">GBS</jats:styled-content> in this study.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Retrospective study was conducted in 114 patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> and 120 age‐ and gender‐matched individuals.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Absolute monocyte count in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> was higher than that in healthy controls (0.61 ± 0.24 vs 0.41 ± 0.10; <jats:italic>P</jats:italic> < .001). Interestingly, monocyte count had significant positive correlations with <jats:styled-content style="fixed-case">CRP</jats:styled-content>,<jats:styled-content style="fixed-case"> ESR</jats:styled-content>, and disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content> (<jats:italic>r</jats:italic> = .244, <jats:italic>P</jats:italic> = .009; <jats:italic>r</jats:italic> = .269, <jats:italic>P</jats:italic> = .004; <jats:italic>r</jats:italic> = .322, <jats:italic>P</jats:italic> < .001). A cutoff value of 0.515 for monocyte count was observed in patients with <jats:styled-content style="fixed-case">GBS</jats:styled-content> (areas under the curve = 0.808, 95% confidence interval = 0.749‐0.868, <jats:italic>P</jats:italic> < .001). Meanwhile, absolute monocyte count was independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> in logistic regression analysis (odds ratio = 2.291, 95% confidence interval = 3.557‐27.493, <jats:italic>P</jats:italic> < .001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings demonstrated that elevated monocyte count is independently associated with <jats:styled-content style="fixed-case">GBS</jats:styled-content> patients, and suggested monocyte count is positively associated with disease severity of <jats:styled-content style="fixed-case">GBS</jats:styled-content>.</jats:p></jats:sec> Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? International Journal of Laboratory Hematology |
| spellingShingle | Li, X., Li, W., Luo, Y., Qin, L., Su, Q., Mo, W., International Journal of Laboratory Hematology, Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count?, Biochemistry (medical), Clinical Biochemistry, Hematology, General Medicine |
| title | Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_full | Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_fullStr | Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_full_unstemmed | Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_short | Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| title_sort | can we assess severity of guillain‐barré syndrome using absolute monocyte count? |
| title_unstemmed | Can we assess severity of Guillain‐Barré syndrome using absolute monocyte count? |
| topic | Biochemistry (medical), Clinical Biochemistry, Hematology, General Medicine |
| url | http://dx.doi.org/10.1111/ijlh.12845 |