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Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults
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| Zeitschriftentitel: | Clinical Physiology and Functional Imaging |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Clinical Physiology and Functional Imaging, 38, 2018, 3, S. 502-507 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Harbin, Michelle M. Ostrem, Joseph D. Evanoff, Nicholas G. Kelly, Aaron S. Dengel, Donald R. Harbin, Michelle M. Ostrem, Joseph D. Evanoff, Nicholas G. Kelly, Aaron S. Dengel, Donald R. |
|---|---|
| author |
Harbin, Michelle M. Ostrem, Joseph D. Evanoff, Nicholas G. Kelly, Aaron S. Dengel, Donald R. |
| spellingShingle |
Harbin, Michelle M. Ostrem, Joseph D. Evanoff, Nicholas G. Kelly, Aaron S. Dengel, Donald R. Clinical Physiology and Functional Imaging Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults Physiology (medical) General Medicine Physiology General Medicine |
| author_sort |
harbin, michelle m. |
| spelling |
Harbin, Michelle M. Ostrem, Joseph D. Evanoff, Nicholas G. Kelly, Aaron S. Dengel, Donald R. 1475-0961 1475-097X Wiley Physiology (medical) General Medicine Physiology General Medicine http://dx.doi.org/10.1111/cpf.12448 <jats:title>Summary</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>When assessing brachial endothelial function by reactive hyperaemia, stopping blood flow creates a period of low‐flow‐mediated constriction (L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>). As little is known about how this parameter influences flow‐mediated vasodilation (<jats:styled-content style="fixed-case">FMD</jats:styled-content>), the purpose of this study was to better understand this relationship and to determine the intra‐ and interday reproducibility of brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and <jats:styled-content style="fixed-case">FMD</jats:styled-content> were measured on 26 healthy, young adults (13 males, 13 females; 24·6 ± 2·7 years). Each participant had two assessments conducted on two separate visits, separated by a minimum of seven days. Brachial artery baseline diameter was imaged during rest. Continuous imaging of the artery was performed during the last 20 s of cuff‐occlusion to 180 s postcuff release. An L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> was considered present if the relative change from pre‐occlusion baseline to L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> artery diameter was less than −0·1%.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Overall, there was a strong, positive correlation between increased brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and blunted <jats:styled-content style="fixed-case">FMD</jats:styled-content> (visit 1 test 1: <jats:italic>r</jats:italic> = 0·758, <jats:italic>P</jats:italic><0·001; visit 1 test 2: <jats:italic>r</jats:italic> = 0·706, <jats:italic>P</jats:italic><0·001; visit 2 test 1: <jats:italic>r</jats:italic> = 0·836, <jats:italic>P</jats:italic><0·001; visit 2 test 2: <jats:italic>r</jats:italic> = 0·857, <jats:italic>P</jats:italic><0·001). The reproducibility of intra‐ and interday L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> diameter was intraclass correlation coefficients (<jats:styled-content style="fixed-case">ICC</jats:styled-content>) = 0·627, coefficient of variation (<jats:styled-content style="fixed-case">CV</jats:styled-content>) = 54·4% and <jats:styled-content style="fixed-case">ICC</jats:styled-content> = 0·734, <jats:styled-content style="fixed-case">CV</jats:styled-content> = 43·5%, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Vasoconstriction to low‐flow conditions influences the subsequent maximal dilation during reactive hyperaemia. However, L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> is variable as evidenced by the weak intra‐ and interday reproducibility of the measure. Further research should study brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> reproducibility among varying populations and the implications L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> has on the interpretation of <jats:styled-content style="fixed-case">FMD</jats:styled-content> results.</jats:p></jats:sec> Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults Clinical Physiology and Functional Imaging |
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10.1111/cpf.12448 |
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Wiley, 2018 |
| imprint_str_mv |
Wiley, 2018 |
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2018 |
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Wiley |
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Clinical Physiology and Functional Imaging |
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49 |
| title |
Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_unstemmed |
Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_full |
Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_fullStr |
Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_full_unstemmed |
Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_short |
Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_sort |
intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| topic |
Physiology (medical) General Medicine Physiology General Medicine |
| url |
http://dx.doi.org/10.1111/cpf.12448 |
| publishDate |
2018 |
| physical |
502-507 |
| description |
<jats:title>Summary</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>When assessing brachial endothelial function by reactive hyperaemia, stopping blood flow creates a period of low‐flow‐mediated constriction (L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>). As little is known about how this parameter influences flow‐mediated vasodilation (<jats:styled-content style="fixed-case">FMD</jats:styled-content>), the purpose of this study was to better understand this relationship and to determine the intra‐ and interday reproducibility of brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and <jats:styled-content style="fixed-case">FMD</jats:styled-content> were measured on 26 healthy, young adults (13 males, 13 females; 24·6 ± 2·7 years). Each participant had two assessments conducted on two separate visits, separated by a minimum of seven days. Brachial artery baseline diameter was imaged during rest. Continuous imaging of the artery was performed during the last 20 s of cuff‐occlusion to 180 s postcuff release. An L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> was considered present if the relative change from pre‐occlusion baseline to L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> artery diameter was less than −0·1%.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Overall, there was a strong, positive correlation between increased brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and blunted <jats:styled-content style="fixed-case">FMD</jats:styled-content> (visit 1 test 1: <jats:italic>r</jats:italic> = 0·758, <jats:italic>P</jats:italic><0·001; visit 1 test 2: <jats:italic>r</jats:italic> = 0·706, <jats:italic>P</jats:italic><0·001; visit 2 test 1: <jats:italic>r</jats:italic> = 0·836, <jats:italic>P</jats:italic><0·001; visit 2 test 2: <jats:italic>r</jats:italic> = 0·857, <jats:italic>P</jats:italic><0·001). The reproducibility of intra‐ and interday L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> diameter was intraclass correlation coefficients (<jats:styled-content style="fixed-case">ICC</jats:styled-content>) = 0·627, coefficient of variation (<jats:styled-content style="fixed-case">CV</jats:styled-content>) = 54·4% and <jats:styled-content style="fixed-case">ICC</jats:styled-content> = 0·734, <jats:styled-content style="fixed-case">CV</jats:styled-content> = 43·5%, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Vasoconstriction to low‐flow conditions influences the subsequent maximal dilation during reactive hyperaemia. However, L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> is variable as evidenced by the weak intra‐ and interday reproducibility of the measure. Further research should study brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> reproducibility among varying populations and the implications L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> has on the interpretation of <jats:styled-content style="fixed-case">FMD</jats:styled-content> results.</jats:p></jats:sec> |
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| author | Harbin, Michelle M., Ostrem, Joseph D., Evanoff, Nicholas G., Kelly, Aaron S., Dengel, Donald R. |
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| description | <jats:title>Summary</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>When assessing brachial endothelial function by reactive hyperaemia, stopping blood flow creates a period of low‐flow‐mediated constriction (L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>). As little is known about how this parameter influences flow‐mediated vasodilation (<jats:styled-content style="fixed-case">FMD</jats:styled-content>), the purpose of this study was to better understand this relationship and to determine the intra‐ and interday reproducibility of brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and <jats:styled-content style="fixed-case">FMD</jats:styled-content> were measured on 26 healthy, young adults (13 males, 13 females; 24·6 ± 2·7 years). Each participant had two assessments conducted on two separate visits, separated by a minimum of seven days. Brachial artery baseline diameter was imaged during rest. Continuous imaging of the artery was performed during the last 20 s of cuff‐occlusion to 180 s postcuff release. An L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> was considered present if the relative change from pre‐occlusion baseline to L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> artery diameter was less than −0·1%.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Overall, there was a strong, positive correlation between increased brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and blunted <jats:styled-content style="fixed-case">FMD</jats:styled-content> (visit 1 test 1: <jats:italic>r</jats:italic> = 0·758, <jats:italic>P</jats:italic><0·001; visit 1 test 2: <jats:italic>r</jats:italic> = 0·706, <jats:italic>P</jats:italic><0·001; visit 2 test 1: <jats:italic>r</jats:italic> = 0·836, <jats:italic>P</jats:italic><0·001; visit 2 test 2: <jats:italic>r</jats:italic> = 0·857, <jats:italic>P</jats:italic><0·001). The reproducibility of intra‐ and interday L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> diameter was intraclass correlation coefficients (<jats:styled-content style="fixed-case">ICC</jats:styled-content>) = 0·627, coefficient of variation (<jats:styled-content style="fixed-case">CV</jats:styled-content>) = 54·4% and <jats:styled-content style="fixed-case">ICC</jats:styled-content> = 0·734, <jats:styled-content style="fixed-case">CV</jats:styled-content> = 43·5%, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Vasoconstriction to low‐flow conditions influences the subsequent maximal dilation during reactive hyperaemia. However, L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> is variable as evidenced by the weak intra‐ and interday reproducibility of the measure. Further research should study brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> reproducibility among varying populations and the implications L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> has on the interpretation of <jats:styled-content style="fixed-case">FMD</jats:styled-content> results.</jats:p></jats:sec> |
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| imprint | Wiley, 2018 |
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| spelling | Harbin, Michelle M. Ostrem, Joseph D. Evanoff, Nicholas G. Kelly, Aaron S. Dengel, Donald R. 1475-0961 1475-097X Wiley Physiology (medical) General Medicine Physiology General Medicine http://dx.doi.org/10.1111/cpf.12448 <jats:title>Summary</jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>When assessing brachial endothelial function by reactive hyperaemia, stopping blood flow creates a period of low‐flow‐mediated constriction (L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>). As little is known about how this parameter influences flow‐mediated vasodilation (<jats:styled-content style="fixed-case">FMD</jats:styled-content>), the purpose of this study was to better understand this relationship and to determine the intra‐ and interday reproducibility of brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and <jats:styled-content style="fixed-case">FMD</jats:styled-content> were measured on 26 healthy, young adults (13 males, 13 females; 24·6 ± 2·7 years). Each participant had two assessments conducted on two separate visits, separated by a minimum of seven days. Brachial artery baseline diameter was imaged during rest. Continuous imaging of the artery was performed during the last 20 s of cuff‐occlusion to 180 s postcuff release. An L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> was considered present if the relative change from pre‐occlusion baseline to L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> artery diameter was less than −0·1%.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Overall, there was a strong, positive correlation between increased brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> and blunted <jats:styled-content style="fixed-case">FMD</jats:styled-content> (visit 1 test 1: <jats:italic>r</jats:italic> = 0·758, <jats:italic>P</jats:italic><0·001; visit 1 test 2: <jats:italic>r</jats:italic> = 0·706, <jats:italic>P</jats:italic><0·001; visit 2 test 1: <jats:italic>r</jats:italic> = 0·836, <jats:italic>P</jats:italic><0·001; visit 2 test 2: <jats:italic>r</jats:italic> = 0·857, <jats:italic>P</jats:italic><0·001). The reproducibility of intra‐ and interday L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> diameter was intraclass correlation coefficients (<jats:styled-content style="fixed-case">ICC</jats:styled-content>) = 0·627, coefficient of variation (<jats:styled-content style="fixed-case">CV</jats:styled-content>) = 54·4% and <jats:styled-content style="fixed-case">ICC</jats:styled-content> = 0·734, <jats:styled-content style="fixed-case">CV</jats:styled-content> = 43·5%, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Vasoconstriction to low‐flow conditions influences the subsequent maximal dilation during reactive hyperaemia. However, L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> is variable as evidenced by the weak intra‐ and interday reproducibility of the measure. Further research should study brachial L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> reproducibility among varying populations and the implications L‐<jats:styled-content style="fixed-case">FMC</jats:styled-content> has on the interpretation of <jats:styled-content style="fixed-case">FMD</jats:styled-content> results.</jats:p></jats:sec> Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults Clinical Physiology and Functional Imaging |
| spellingShingle | Harbin, Michelle M., Ostrem, Joseph D., Evanoff, Nicholas G., Kelly, Aaron S., Dengel, Donald R., Clinical Physiology and Functional Imaging, Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults, Physiology (medical), General Medicine, Physiology, General Medicine |
| title | Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_full | Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_fullStr | Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_full_unstemmed | Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_short | Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_sort | intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| title_unstemmed | Intra‐ and inter‐day reproducibility of low‐flow mediated constriction response in young adults |
| topic | Physiology (medical), General Medicine, Physiology, General Medicine |
| url | http://dx.doi.org/10.1111/cpf.12448 |