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Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption
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| Zeitschriftentitel: | CNS Neuroscience & Therapeutics |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | CNS Neuroscience & Therapeutics, 26, 2020, 2, S. 228-239 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Zhang, Rui Liu, Yun Chen, Yan Li, Qian Marshall, Charles Wu, Ting Hu, Gang Xiao, Ming Zhang, Rui Liu, Yun Chen, Yan Li, Qian Marshall, Charles Wu, Ting Hu, Gang Xiao, Ming |
|---|---|
| author |
Zhang, Rui Liu, Yun Chen, Yan Li, Qian Marshall, Charles Wu, Ting Hu, Gang Xiao, Ming |
| spellingShingle |
Zhang, Rui Liu, Yun Chen, Yan Li, Qian Marshall, Charles Wu, Ting Hu, Gang Xiao, Ming CNS Neuroscience & Therapeutics Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
zhang, rui |
| spelling |
Zhang, Rui Liu, Yun Chen, Yan Li, Qian Marshall, Charles Wu, Ting Hu, Gang Xiao, Ming 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13194 <jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via the glymphatic system. The aim of the present study was to investigate pathophysiological roles of astroglial aquaporin 4 (AQP4), a functional regulator of glymphatic clearance, in a mouse model of chronic sleep disruption (SD).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Adult AQP4 null mice and wild‐type (WT) mice were given 7 days of SD using the improved rotating rod method, and then received behavioral, neuropathological, and neurochemical analyses.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Aquaporin 4 deletion resulted in an impairment of glymphatic transport and accumulation of β‐amyloid and Tau proteins in the brain following SD. AQP4 null SD mice exhibited severe activation of microglia, neuroinflammation, and synaptic protein loss in the hippocampus, as well as decreased working memory, compared with WT‐SD mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results demonstrate that AQP4‐mediated glymphatic clearance ameliorates brain impairments caused by abnormal accumulation of metabolic wastes following chronic SD, thus serving as a potential target for sleep‐related disorders.</jats:p></jats:sec> Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption CNS Neuroscience & Therapeutics |
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10.1111/cns.13194 |
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| title |
Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_unstemmed |
Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_full |
Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_fullStr |
Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_full_unstemmed |
Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_short |
Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_sort |
aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| topic |
Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| url |
http://dx.doi.org/10.1111/cns.13194 |
| publishDate |
2020 |
| physical |
228-239 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via the glymphatic system. The aim of the present study was to investigate pathophysiological roles of astroglial aquaporin 4 (AQP4), a functional regulator of glymphatic clearance, in a mouse model of chronic sleep disruption (SD).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Adult AQP4 null mice and wild‐type (WT) mice were given 7 days of SD using the improved rotating rod method, and then received behavioral, neuropathological, and neurochemical analyses.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Aquaporin 4 deletion resulted in an impairment of glymphatic transport and accumulation of β‐amyloid and Tau proteins in the brain following SD. AQP4 null SD mice exhibited severe activation of microglia, neuroinflammation, and synaptic protein loss in the hippocampus, as well as decreased working memory, compared with WT‐SD mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results demonstrate that AQP4‐mediated glymphatic clearance ameliorates brain impairments caused by abnormal accumulation of metabolic wastes following chronic SD, thus serving as a potential target for sleep‐related disorders.</jats:p></jats:sec> |
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| author | Zhang, Rui, Liu, Yun, Chen, Yan, Li, Qian, Marshall, Charles, Wu, Ting, Hu, Gang, Xiao, Ming |
| author_facet | Zhang, Rui, Liu, Yun, Chen, Yan, Li, Qian, Marshall, Charles, Wu, Ting, Hu, Gang, Xiao, Ming, Zhang, Rui, Liu, Yun, Chen, Yan, Li, Qian, Marshall, Charles, Wu, Ting, Hu, Gang, Xiao, Ming |
| author_sort | zhang, rui |
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| container_title | CNS Neuroscience & Therapeutics |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via the glymphatic system. The aim of the present study was to investigate pathophysiological roles of astroglial aquaporin 4 (AQP4), a functional regulator of glymphatic clearance, in a mouse model of chronic sleep disruption (SD).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Adult AQP4 null mice and wild‐type (WT) mice were given 7 days of SD using the improved rotating rod method, and then received behavioral, neuropathological, and neurochemical analyses.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Aquaporin 4 deletion resulted in an impairment of glymphatic transport and accumulation of β‐amyloid and Tau proteins in the brain following SD. AQP4 null SD mice exhibited severe activation of microglia, neuroinflammation, and synaptic protein loss in the hippocampus, as well as decreased working memory, compared with WT‐SD mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results demonstrate that AQP4‐mediated glymphatic clearance ameliorates brain impairments caused by abnormal accumulation of metabolic wastes following chronic SD, thus serving as a potential target for sleep‐related disorders.</jats:p></jats:sec> |
| doi_str_mv | 10.1111/cns.13194 |
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| imprint_str_mv | Wiley, 2020 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Zhang, Rui Liu, Yun Chen, Yan Li, Qian Marshall, Charles Wu, Ting Hu, Gang Xiao, Ming 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13194 <jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via the glymphatic system. The aim of the present study was to investigate pathophysiological roles of astroglial aquaporin 4 (AQP4), a functional regulator of glymphatic clearance, in a mouse model of chronic sleep disruption (SD).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Adult AQP4 null mice and wild‐type (WT) mice were given 7 days of SD using the improved rotating rod method, and then received behavioral, neuropathological, and neurochemical analyses.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Aquaporin 4 deletion resulted in an impairment of glymphatic transport and accumulation of β‐amyloid and Tau proteins in the brain following SD. AQP4 null SD mice exhibited severe activation of microglia, neuroinflammation, and synaptic protein loss in the hippocampus, as well as decreased working memory, compared with WT‐SD mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These results demonstrate that AQP4‐mediated glymphatic clearance ameliorates brain impairments caused by abnormal accumulation of metabolic wastes following chronic SD, thus serving as a potential target for sleep‐related disorders.</jats:p></jats:sec> Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption CNS Neuroscience & Therapeutics |
| spellingShingle | Zhang, Rui, Liu, Yun, Chen, Yan, Li, Qian, Marshall, Charles, Wu, Ting, Hu, Gang, Xiao, Ming, CNS Neuroscience & Therapeutics, Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| title | Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_full | Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_fullStr | Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_full_unstemmed | Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_short | Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_sort | aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| title_unstemmed | Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption |
| topic | Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1111/cns.13194 |