Eintrag weiter verarbeiten
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population
Gespeichert in:
| Zeitschriftentitel: | CNS Neuroscience & Therapeutics |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | CNS Neuroscience & Therapeutics, 26, 2020, 1, S. 30-38 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Park, Chun Il Hwang, Syung Shick Kim, Hae Won Kang, Jee In Lee, Sang Hak Kim, Se Joo Park, Chun Il Hwang, Syung Shick Kim, Hae Won Kang, Jee In Lee, Sang Hak Kim, Se Joo |
|---|---|
| author |
Park, Chun Il Hwang, Syung Shick Kim, Hae Won Kang, Jee In Lee, Sang Hak Kim, Se Joo |
| spellingShingle |
Park, Chun Il Hwang, Syung Shick Kim, Hae Won Kang, Jee In Lee, Sang Hak Kim, Se Joo CNS Neuroscience & Therapeutics Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
park, chun il |
| spelling |
Park, Chun Il Hwang, Syung Shick Kim, Hae Won Kang, Jee In Lee, Sang Hak Kim, Se Joo 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13138 <jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three μ‐opioid receptor gene (<jats:italic>OPRM1</jats:italic>) variants and two κ‐opioid receptor gene (<jats:italic>OPRK1</jats:italic>) variants were examined in 314 male patients with AUD and 324 male controls. We applied the Alcohol Use Disorders Identification Test (AUDIT), Obsessive Compulsive Drinking Scale (OCDS), and Alcohol Dependence Scale. AUD patients also completed the stop‐signal task, delay discounting task, balloon analogue risk task, and the Barratt Impulsiveness Scale version 11 (BIS‐11).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No significant differences in genotype distributions or haplotype frequencies were found between AUD patients and controls. However, <jats:italic>OPRK1</jats:italic> SNP rs6473797 was significantly related to the severity of alcohol‐related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients. For other psychological traits, <jats:italic>OPRM1</jats:italic> SNP rs495491 was significantly associated with scores on the motor subfactor of the BIS‐11.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients.</jats:p></jats:sec> Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population CNS Neuroscience & Therapeutics |
| doi_str_mv |
10.1111/cns.13138 |
| facet_avail |
Online Free |
| finc_class_facet |
Psychologie Chemie und Pharmazie Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9jbnMuMTMxMzg |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9jbnMuMTMxMzg |
| institution |
DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 |
| imprint |
Wiley, 2020 |
| imprint_str_mv |
Wiley, 2020 |
| issn |
1755-5930 1755-5949 |
| issn_str_mv |
1755-5930 1755-5949 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
park2020associationofopioidreceptorgenepolymorphismswithdrinkingseverityandimpulsivityrelatedtoalcoholusedisorderinakoreanpopulation |
| publishDateSort |
2020 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
CNS Neuroscience & Therapeutics |
| source_id |
49 |
| title |
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_unstemmed |
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_full |
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_fullStr |
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_full_unstemmed |
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_short |
Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_sort |
association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a korean population |
| topic |
Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| url |
http://dx.doi.org/10.1111/cns.13138 |
| publishDate |
2020 |
| physical |
30-38 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three μ‐opioid receptor gene (<jats:italic>OPRM1</jats:italic>) variants and two κ‐opioid receptor gene (<jats:italic>OPRK1</jats:italic>) variants were examined in 314 male patients with AUD and 324 male controls. We applied the Alcohol Use Disorders Identification Test (AUDIT), Obsessive Compulsive Drinking Scale (OCDS), and Alcohol Dependence Scale. AUD patients also completed the stop‐signal task, delay discounting task, balloon analogue risk task, and the Barratt Impulsiveness Scale version 11 (BIS‐11).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No significant differences in genotype distributions or haplotype frequencies were found between AUD patients and controls. However, <jats:italic>OPRK1</jats:italic> SNP rs6473797 was significantly related to the severity of alcohol‐related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients. For other psychological traits, <jats:italic>OPRM1</jats:italic> SNP rs495491 was significantly associated with scores on the motor subfactor of the BIS‐11.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients.</jats:p></jats:sec> |
| container_issue |
1 |
| container_start_page |
30 |
| container_title |
CNS Neuroscience & Therapeutics |
| container_volume |
26 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792334692993728512 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:32:42.609Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Association+of+opioid+receptor+gene+polymorphisms+with+drinking+severity+and+impulsivity+related+to+alcohol+use+disorder+in+a+Korean+population&rft.date=2020-01-01&genre=article&issn=1755-5949&volume=26&issue=1&spage=30&epage=38&pages=30-38&jtitle=CNS+Neuroscience+%26+Therapeutics&atitle=Association+of+opioid+receptor+gene+polymorphisms+with+drinking+severity+and+impulsivity+related+to+alcohol+use+disorder+in+a+Korean+population&aulast=Kim&aufirst=Se+Joo&rft_id=info%3Adoi%2F10.1111%2Fcns.13138&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792334692993728512 |
| author | Park, Chun Il, Hwang, Syung Shick, Kim, Hae Won, Kang, Jee In, Lee, Sang Hak, Kim, Se Joo |
| author_facet | Park, Chun Il, Hwang, Syung Shick, Kim, Hae Won, Kang, Jee In, Lee, Sang Hak, Kim, Se Joo, Park, Chun Il, Hwang, Syung Shick, Kim, Hae Won, Kang, Jee In, Lee, Sang Hak, Kim, Se Joo |
| author_sort | park, chun il |
| container_issue | 1 |
| container_start_page | 30 |
| container_title | CNS Neuroscience & Therapeutics |
| container_volume | 26 |
| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three μ‐opioid receptor gene (<jats:italic>OPRM1</jats:italic>) variants and two κ‐opioid receptor gene (<jats:italic>OPRK1</jats:italic>) variants were examined in 314 male patients with AUD and 324 male controls. We applied the Alcohol Use Disorders Identification Test (AUDIT), Obsessive Compulsive Drinking Scale (OCDS), and Alcohol Dependence Scale. AUD patients also completed the stop‐signal task, delay discounting task, balloon analogue risk task, and the Barratt Impulsiveness Scale version 11 (BIS‐11).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No significant differences in genotype distributions or haplotype frequencies were found between AUD patients and controls. However, <jats:italic>OPRK1</jats:italic> SNP rs6473797 was significantly related to the severity of alcohol‐related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients. For other psychological traits, <jats:italic>OPRM1</jats:italic> SNP rs495491 was significantly associated with scores on the motor subfactor of the BIS‐11.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients.</jats:p></jats:sec> |
| doi_str_mv | 10.1111/cns.13138 |
| facet_avail | Online, Free |
| finc_class_facet | Psychologie, Chemie und Pharmazie, Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9jbnMuMTMxMzg |
| imprint | Wiley, 2020 |
| imprint_str_mv | Wiley, 2020 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 1755-5930, 1755-5949 |
| issn_str_mv | 1755-5930, 1755-5949 |
| language | English |
| last_indexed | 2024-03-01T14:32:42.609Z |
| match_str | park2020associationofopioidreceptorgenepolymorphismswithdrinkingseverityandimpulsivityrelatedtoalcoholusedisorderinakoreanpopulation |
| mega_collection | Wiley (CrossRef) |
| physical | 30-38 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | CNS Neuroscience & Therapeutics |
| source_id | 49 |
| spelling | Park, Chun Il Hwang, Syung Shick Kim, Hae Won Kang, Jee In Lee, Sang Hak Kim, Se Joo 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13138 <jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three μ‐opioid receptor gene (<jats:italic>OPRM1</jats:italic>) variants and two κ‐opioid receptor gene (<jats:italic>OPRK1</jats:italic>) variants were examined in 314 male patients with AUD and 324 male controls. We applied the Alcohol Use Disorders Identification Test (AUDIT), Obsessive Compulsive Drinking Scale (OCDS), and Alcohol Dependence Scale. AUD patients also completed the stop‐signal task, delay discounting task, balloon analogue risk task, and the Barratt Impulsiveness Scale version 11 (BIS‐11).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No significant differences in genotype distributions or haplotype frequencies were found between AUD patients and controls. However, <jats:italic>OPRK1</jats:italic> SNP rs6473797 was significantly related to the severity of alcohol‐related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients. For other psychological traits, <jats:italic>OPRM1</jats:italic> SNP rs495491 was significantly associated with scores on the motor subfactor of the BIS‐11.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients.</jats:p></jats:sec> Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population CNS Neuroscience & Therapeutics |
| spellingShingle | Park, Chun Il, Hwang, Syung Shick, Kim, Hae Won, Kang, Jee In, Lee, Sang Hak, Kim, Se Joo, CNS Neuroscience & Therapeutics, Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| title | Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_full | Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_fullStr | Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_full_unstemmed | Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_short | Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| title_sort | association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a korean population |
| title_unstemmed | Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population |
| topic | Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1111/cns.13138 |