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Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer
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| Zeitschriftentitel: | Cancer Science |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Cancer Science, 104, 2013, 4, S. 423-430 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Zhou, Lin Zhang, Ruifeng Zhang, Lianfeng Sun, Yuling Yao, Weiyan Zhao, Ahong Li, Jiansheng Yuan, Yaozong Zhou, Lin Zhang, Ruifeng Zhang, Lianfeng Sun, Yuling Yao, Weiyan Zhao, Ahong Li, Jiansheng Yuan, Yaozong |
|---|---|
| author |
Zhou, Lin Zhang, Ruifeng Zhang, Lianfeng Sun, Yuling Yao, Weiyan Zhao, Ahong Li, Jiansheng Yuan, Yaozong |
| spellingShingle |
Zhou, Lin Zhang, Ruifeng Zhang, Lianfeng Sun, Yuling Yao, Weiyan Zhao, Ahong Li, Jiansheng Yuan, Yaozong Cancer Science Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer Cancer Research Oncology General Medicine |
| author_sort |
zhou, lin |
| spelling |
Zhou, Lin Zhang, Ruifeng Zhang, Lianfeng Sun, Yuling Yao, Weiyan Zhao, Ahong Li, Jiansheng Yuan, Yaozong 1347-9032 1349-7006 Wiley Cancer Research Oncology General Medicine http://dx.doi.org/10.1111/cas.12107 <jats:p>Transgelin is a known actin‐binding protein, which plays a role in regulating the functions of smooth muscle cells or fibroblasts. Recent evidence indicates that transgelin is involved in diverse human cancers, yet its role in pancreatic cancer remains unclear. We therefore evaluated the expression characteristics and function of transgelin in pancreatic cancer. Immunohistochemical analysis of benign (<jats:italic>n</jats:italic> = 30 patients) and malignant (<jats:italic>n</jats:italic> = 114 patients) pancreatic ductal cells showed significantly higher transgelin staining in malignant cells. Lymph node metastasis (<jats:italic>P </jats:italic>= 0.026) and diabetes (<jats:italic>P</jats:italic> = 0.041) were shown to significantly correlate with transgelin protein expression. Patients with high transgelin expression showed a shorter 5‐year overall survival and a lower tumor‐specific survival than those with low transgelin expression. Multivariate analysis revealed that transgelin was an independent factor affecting pancreatic tumor‐specific survival (<jats:italic>P </jats:italic>= 0.025). <jats:italic>In vitro</jats:italic>,<jats:styled-content style="fixed-case"> RNA</jats:styled-content> interference‐mediated transgelin knockdown resulted in inhibition of pancreatic cancer cell proliferation, migration and invasion. Depletion of transgelin expression could suppress pancreatic tumorigenicity and tumor growth <jats:italic>in vivo</jats:italic>, and produce enhanced cytotoxic effects of gemcitabine on pancreatic cancer cells both <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>. Our results indicate that transgelin plays a promoting role in tumor progression, and appears to be a novel prognostic marker for advanced pancreatic cancer.</jats:p> Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer Cancer Science |
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10.1111/cas.12107 |
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Wiley, 2013 |
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Wiley, 2013 |
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Cancer Science |
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| title |
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_unstemmed |
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_full |
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_fullStr |
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_full_unstemmed |
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_short |
Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_sort |
upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| topic |
Cancer Research Oncology General Medicine |
| url |
http://dx.doi.org/10.1111/cas.12107 |
| publishDate |
2013 |
| physical |
423-430 |
| description |
<jats:p>Transgelin is a known actin‐binding protein, which plays a role in regulating the functions of smooth muscle cells or fibroblasts. Recent evidence indicates that transgelin is involved in diverse human cancers, yet its role in pancreatic cancer remains unclear. We therefore evaluated the expression characteristics and function of transgelin in pancreatic cancer. Immunohistochemical analysis of benign (<jats:italic>n</jats:italic> = 30 patients) and malignant (<jats:italic>n</jats:italic> = 114 patients) pancreatic ductal cells showed significantly higher transgelin staining in malignant cells. Lymph node metastasis (<jats:italic>P </jats:italic>= 0.026) and diabetes (<jats:italic>P</jats:italic> = 0.041) were shown to significantly correlate with transgelin protein expression. Patients with high transgelin expression showed a shorter 5‐year overall survival and a lower tumor‐specific survival than those with low transgelin expression. Multivariate analysis revealed that transgelin was an independent factor affecting pancreatic tumor‐specific survival (<jats:italic>P </jats:italic>= 0.025). <jats:italic>In vitro</jats:italic>,<jats:styled-content style="fixed-case"> RNA</jats:styled-content> interference‐mediated transgelin knockdown resulted in inhibition of pancreatic cancer cell proliferation, migration and invasion. Depletion of transgelin expression could suppress pancreatic tumorigenicity and tumor growth <jats:italic>in vivo</jats:italic>, and produce enhanced cytotoxic effects of gemcitabine on pancreatic cancer cells both <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>. Our results indicate that transgelin plays a promoting role in tumor progression, and appears to be a novel prognostic marker for advanced pancreatic cancer.</jats:p> |
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| author | Zhou, Lin, Zhang, Ruifeng, Zhang, Lianfeng, Sun, Yuling, Yao, Weiyan, Zhao, Ahong, Li, Jiansheng, Yuan, Yaozong |
| author_facet | Zhou, Lin, Zhang, Ruifeng, Zhang, Lianfeng, Sun, Yuling, Yao, Weiyan, Zhao, Ahong, Li, Jiansheng, Yuan, Yaozong, Zhou, Lin, Zhang, Ruifeng, Zhang, Lianfeng, Sun, Yuling, Yao, Weiyan, Zhao, Ahong, Li, Jiansheng, Yuan, Yaozong |
| author_sort | zhou, lin |
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| description | <jats:p>Transgelin is a known actin‐binding protein, which plays a role in regulating the functions of smooth muscle cells or fibroblasts. Recent evidence indicates that transgelin is involved in diverse human cancers, yet its role in pancreatic cancer remains unclear. We therefore evaluated the expression characteristics and function of transgelin in pancreatic cancer. Immunohistochemical analysis of benign (<jats:italic>n</jats:italic> = 30 patients) and malignant (<jats:italic>n</jats:italic> = 114 patients) pancreatic ductal cells showed significantly higher transgelin staining in malignant cells. Lymph node metastasis (<jats:italic>P </jats:italic>= 0.026) and diabetes (<jats:italic>P</jats:italic> = 0.041) were shown to significantly correlate with transgelin protein expression. Patients with high transgelin expression showed a shorter 5‐year overall survival and a lower tumor‐specific survival than those with low transgelin expression. Multivariate analysis revealed that transgelin was an independent factor affecting pancreatic tumor‐specific survival (<jats:italic>P </jats:italic>= 0.025). <jats:italic>In vitro</jats:italic>,<jats:styled-content style="fixed-case"> RNA</jats:styled-content> interference‐mediated transgelin knockdown resulted in inhibition of pancreatic cancer cell proliferation, migration and invasion. Depletion of transgelin expression could suppress pancreatic tumorigenicity and tumor growth <jats:italic>in vivo</jats:italic>, and produce enhanced cytotoxic effects of gemcitabine on pancreatic cancer cells both <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>. Our results indicate that transgelin plays a promoting role in tumor progression, and appears to be a novel prognostic marker for advanced pancreatic cancer.</jats:p> |
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| imprint | Wiley, 2013 |
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| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 1347-9032, 1349-7006 |
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| spelling | Zhou, Lin Zhang, Ruifeng Zhang, Lianfeng Sun, Yuling Yao, Weiyan Zhao, Ahong Li, Jiansheng Yuan, Yaozong 1347-9032 1349-7006 Wiley Cancer Research Oncology General Medicine http://dx.doi.org/10.1111/cas.12107 <jats:p>Transgelin is a known actin‐binding protein, which plays a role in regulating the functions of smooth muscle cells or fibroblasts. Recent evidence indicates that transgelin is involved in diverse human cancers, yet its role in pancreatic cancer remains unclear. We therefore evaluated the expression characteristics and function of transgelin in pancreatic cancer. Immunohistochemical analysis of benign (<jats:italic>n</jats:italic> = 30 patients) and malignant (<jats:italic>n</jats:italic> = 114 patients) pancreatic ductal cells showed significantly higher transgelin staining in malignant cells. Lymph node metastasis (<jats:italic>P </jats:italic>= 0.026) and diabetes (<jats:italic>P</jats:italic> = 0.041) were shown to significantly correlate with transgelin protein expression. Patients with high transgelin expression showed a shorter 5‐year overall survival and a lower tumor‐specific survival than those with low transgelin expression. Multivariate analysis revealed that transgelin was an independent factor affecting pancreatic tumor‐specific survival (<jats:italic>P </jats:italic>= 0.025). <jats:italic>In vitro</jats:italic>,<jats:styled-content style="fixed-case"> RNA</jats:styled-content> interference‐mediated transgelin knockdown resulted in inhibition of pancreatic cancer cell proliferation, migration and invasion. Depletion of transgelin expression could suppress pancreatic tumorigenicity and tumor growth <jats:italic>in vivo</jats:italic>, and produce enhanced cytotoxic effects of gemcitabine on pancreatic cancer cells both <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>. Our results indicate that transgelin plays a promoting role in tumor progression, and appears to be a novel prognostic marker for advanced pancreatic cancer.</jats:p> Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer Cancer Science |
| spellingShingle | Zhou, Lin, Zhang, Ruifeng, Zhang, Lianfeng, Sun, Yuling, Yao, Weiyan, Zhao, Ahong, Li, Jiansheng, Yuan, Yaozong, Cancer Science, Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer, Cancer Research, Oncology, General Medicine |
| title | Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_full | Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_fullStr | Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_full_unstemmed | Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_short | Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_sort | upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| title_unstemmed | Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer |
| topic | Cancer Research, Oncology, General Medicine |
| url | http://dx.doi.org/10.1111/cas.12107 |