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The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis
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| Zeitschriftentitel: | APMIS |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | APMIS, 126, 2018, 1, S. 85-91 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Blom, Kristin Elshafie, Amir I. Jönsson, Ulla‐Britt Rönnelid, Johan Håkansson, Lena Douhan Venge, Per Blom, Kristin Elshafie, Amir I. Jönsson, Ulla‐Britt Rönnelid, Johan Håkansson, Lena Douhan Venge, Per |
|---|---|
| author |
Blom, Kristin Elshafie, Amir I. Jönsson, Ulla‐Britt Rönnelid, Johan Håkansson, Lena Douhan Venge, Per |
| spellingShingle |
Blom, Kristin Elshafie, Amir I. Jönsson, Ulla‐Britt Rönnelid, Johan Håkansson, Lena Douhan Venge, Per APMIS The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine |
| author_sort |
blom, kristin |
| spelling |
Blom, Kristin Elshafie, Amir I. Jönsson, Ulla‐Britt Rönnelid, Johan Håkansson, Lena Douhan Venge, Per 0903-4641 1600-0463 Wiley Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine http://dx.doi.org/10.1111/apm.12780 <jats:p>Visceral leishmaniasis (<jats:styled-content style="fixed-case">VL</jats:styled-content>) is the most severe form of leishmaniasis. Recent findings indicate that dendritic cells have a key role in the defense against the Leishmania parasite and that the activity of this cell may be modified by the eosinophil secretory protein eosinophil‐derived neurotoxin (<jats:styled-content style="fixed-case">EDN</jats:styled-content>). We hypothesized that the interactions between dendritic cells and <jats:styled-content style="fixed-case">EDN</jats:styled-content> might be of importance in the disease development. Cellular content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was analyzed by <jats:styled-content style="fixed-case">ELISA</jats:styled-content>. The single‐nucleotide polymorphisms at positions 405, 416, and 1122 in the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene were analyzed by real‐time <jats:styled-content style="fixed-case">PCR</jats:styled-content> with TaqMan<jats:sup>®</jats:sup> reagents. The study cohorts comprised 239 Sudanese subjects (65 healthy controls and 174 with <jats:styled-content style="fixed-case">VL</jats:styled-content>) and 300 healthy Swedish controls. The eosinophil content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was lower in <jats:styled-content style="fixed-case">VL</jats:styled-content> as compared with controls (p < 0.0001). The <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 (G>C) genotype distribution was similar among Swedish and Sudanese controls, whereas <jats:styled-content style="fixed-case">VL</jats:styled-content> subjects had a higher prevalence of the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405‐<jats:styled-content style="fixed-case">GG</jats:styled-content> genotype (p < 0.0001). The content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> in the eosinophils was closely linked to the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 polymorphism (p = 0.0002). Our findings suggest that the predisposition to acquire <jats:styled-content style="fixed-case">VL</jats:styled-content> is related to the genetic polymorphism of the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene and the reduced production by the eosinophil of this gene product.</jats:p> The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis APMIS |
| doi_str_mv |
10.1111/apm.12780 |
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Online |
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Medizin Biologie |
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Wiley, 2018 |
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Wiley, 2018 |
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0903-4641 1600-0463 |
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| title |
The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_unstemmed |
The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_full |
The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_fullStr |
The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_full_unstemmed |
The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_short |
The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_sort |
the genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| topic |
Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine |
| url |
http://dx.doi.org/10.1111/apm.12780 |
| publishDate |
2018 |
| physical |
85-91 |
| description |
<jats:p>Visceral leishmaniasis (<jats:styled-content style="fixed-case">VL</jats:styled-content>) is the most severe form of leishmaniasis. Recent findings indicate that dendritic cells have a key role in the defense against the Leishmania parasite and that the activity of this cell may be modified by the eosinophil secretory protein eosinophil‐derived neurotoxin (<jats:styled-content style="fixed-case">EDN</jats:styled-content>). We hypothesized that the interactions between dendritic cells and <jats:styled-content style="fixed-case">EDN</jats:styled-content> might be of importance in the disease development. Cellular content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was analyzed by <jats:styled-content style="fixed-case">ELISA</jats:styled-content>. The single‐nucleotide polymorphisms at positions 405, 416, and 1122 in the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene were analyzed by real‐time <jats:styled-content style="fixed-case">PCR</jats:styled-content> with TaqMan<jats:sup>®</jats:sup> reagents. The study cohorts comprised 239 Sudanese subjects (65 healthy controls and 174 with <jats:styled-content style="fixed-case">VL</jats:styled-content>) and 300 healthy Swedish controls. The eosinophil content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was lower in <jats:styled-content style="fixed-case">VL</jats:styled-content> as compared with controls (p < 0.0001). The <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 (G>C) genotype distribution was similar among Swedish and Sudanese controls, whereas <jats:styled-content style="fixed-case">VL</jats:styled-content> subjects had a higher prevalence of the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405‐<jats:styled-content style="fixed-case">GG</jats:styled-content> genotype (p < 0.0001). The content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> in the eosinophils was closely linked to the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 polymorphism (p = 0.0002). Our findings suggest that the predisposition to acquire <jats:styled-content style="fixed-case">VL</jats:styled-content> is related to the genetic polymorphism of the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene and the reduced production by the eosinophil of this gene product.</jats:p> |
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| author | Blom, Kristin, Elshafie, Amir I., Jönsson, Ulla‐Britt, Rönnelid, Johan, Håkansson, Lena Douhan, Venge, Per |
| author_facet | Blom, Kristin, Elshafie, Amir I., Jönsson, Ulla‐Britt, Rönnelid, Johan, Håkansson, Lena Douhan, Venge, Per, Blom, Kristin, Elshafie, Amir I., Jönsson, Ulla‐Britt, Rönnelid, Johan, Håkansson, Lena Douhan, Venge, Per |
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| description | <jats:p>Visceral leishmaniasis (<jats:styled-content style="fixed-case">VL</jats:styled-content>) is the most severe form of leishmaniasis. Recent findings indicate that dendritic cells have a key role in the defense against the Leishmania parasite and that the activity of this cell may be modified by the eosinophil secretory protein eosinophil‐derived neurotoxin (<jats:styled-content style="fixed-case">EDN</jats:styled-content>). We hypothesized that the interactions between dendritic cells and <jats:styled-content style="fixed-case">EDN</jats:styled-content> might be of importance in the disease development. Cellular content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was analyzed by <jats:styled-content style="fixed-case">ELISA</jats:styled-content>. The single‐nucleotide polymorphisms at positions 405, 416, and 1122 in the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene were analyzed by real‐time <jats:styled-content style="fixed-case">PCR</jats:styled-content> with TaqMan<jats:sup>®</jats:sup> reagents. The study cohorts comprised 239 Sudanese subjects (65 healthy controls and 174 with <jats:styled-content style="fixed-case">VL</jats:styled-content>) and 300 healthy Swedish controls. The eosinophil content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was lower in <jats:styled-content style="fixed-case">VL</jats:styled-content> as compared with controls (p < 0.0001). The <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 (G>C) genotype distribution was similar among Swedish and Sudanese controls, whereas <jats:styled-content style="fixed-case">VL</jats:styled-content> subjects had a higher prevalence of the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405‐<jats:styled-content style="fixed-case">GG</jats:styled-content> genotype (p < 0.0001). The content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> in the eosinophils was closely linked to the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 polymorphism (p = 0.0002). Our findings suggest that the predisposition to acquire <jats:styled-content style="fixed-case">VL</jats:styled-content> is related to the genetic polymorphism of the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene and the reduced production by the eosinophil of this gene product.</jats:p> |
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| spelling | Blom, Kristin Elshafie, Amir I. Jönsson, Ulla‐Britt Rönnelid, Johan Håkansson, Lena Douhan Venge, Per 0903-4641 1600-0463 Wiley Microbiology (medical) General Medicine Immunology and Allergy Pathology and Forensic Medicine http://dx.doi.org/10.1111/apm.12780 <jats:p>Visceral leishmaniasis (<jats:styled-content style="fixed-case">VL</jats:styled-content>) is the most severe form of leishmaniasis. Recent findings indicate that dendritic cells have a key role in the defense against the Leishmania parasite and that the activity of this cell may be modified by the eosinophil secretory protein eosinophil‐derived neurotoxin (<jats:styled-content style="fixed-case">EDN</jats:styled-content>). We hypothesized that the interactions between dendritic cells and <jats:styled-content style="fixed-case">EDN</jats:styled-content> might be of importance in the disease development. Cellular content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was analyzed by <jats:styled-content style="fixed-case">ELISA</jats:styled-content>. The single‐nucleotide polymorphisms at positions 405, 416, and 1122 in the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene were analyzed by real‐time <jats:styled-content style="fixed-case">PCR</jats:styled-content> with TaqMan<jats:sup>®</jats:sup> reagents. The study cohorts comprised 239 Sudanese subjects (65 healthy controls and 174 with <jats:styled-content style="fixed-case">VL</jats:styled-content>) and 300 healthy Swedish controls. The eosinophil content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> was lower in <jats:styled-content style="fixed-case">VL</jats:styled-content> as compared with controls (p < 0.0001). The <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 (G>C) genotype distribution was similar among Swedish and Sudanese controls, whereas <jats:styled-content style="fixed-case">VL</jats:styled-content> subjects had a higher prevalence of the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405‐<jats:styled-content style="fixed-case">GG</jats:styled-content> genotype (p < 0.0001). The content of <jats:styled-content style="fixed-case">EDN</jats:styled-content> in the eosinophils was closely linked to the <jats:styled-content style="fixed-case">EDN</jats:styled-content>405 polymorphism (p = 0.0002). Our findings suggest that the predisposition to acquire <jats:styled-content style="fixed-case">VL</jats:styled-content> is related to the genetic polymorphism of the <jats:styled-content style="fixed-case">EDN</jats:styled-content> gene and the reduced production by the eosinophil of this gene product.</jats:p> The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis APMIS |
| spellingShingle | Blom, Kristin, Elshafie, Amir I., Jönsson, Ulla‐Britt, Rönnelid, Johan, Håkansson, Lena Douhan, Venge, Per, APMIS, The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis, Microbiology (medical), General Medicine, Immunology and Allergy, Pathology and Forensic Medicine |
| title | The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_full | The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_fullStr | The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_full_unstemmed | The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_short | The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_sort | the genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| title_unstemmed | The genetically determined production of the alarmin eosinophil‐derived neurotoxin is reduced in visceral leishmaniasis |
| topic | Microbiology (medical), General Medicine, Immunology and Allergy, Pathology and Forensic Medicine |
| url | http://dx.doi.org/10.1111/apm.12780 |