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Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance
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| Zeitschriftentitel: | Alcoholism: Clinical and Experimental Research |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Alcoholism: Clinical and Experimental Research, 42, 2018, 1, S. 69-80 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Stein, Maria Fey, Werner Koenig, Thomas Oehy, Jacqueline Moggi, Franz Stein, Maria Fey, Werner Koenig, Thomas Oehy, Jacqueline Moggi, Franz |
|---|---|
| author |
Stein, Maria Fey, Werner Koenig, Thomas Oehy, Jacqueline Moggi, Franz |
| spellingShingle |
Stein, Maria Fey, Werner Koenig, Thomas Oehy, Jacqueline Moggi, Franz Alcoholism: Clinical and Experimental Research Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance Psychiatry and Mental health Toxicology Medicine (miscellaneous) |
| author_sort |
stein, maria |
| spelling |
Stein, Maria Fey, Werner Koenig, Thomas Oehy, Jacqueline Moggi, Franz 0145-6008 1530-0277 Wiley Psychiatry and Mental health Toxicology Medicine (miscellaneous) http://dx.doi.org/10.1111/acer.13532 <jats:sec><jats:title>Background</jats:title><jats:p>Most contemporary neuroscientific models of alcohol use disorders (<jats:styled-content style="fixed-case">AUD</jats:styled-content>) incorporate an imbalance between enhanced cue reactivity, which results in a strong urge to consume, and the impaired inhibitory control of that urge. While these phenomena have been frequently investigated separately, studies involving both aspects and thus precisely investigating the postulated imbalance are rare. In this study, inhibition was investigated in an addiction‐specific context and individual craving levels were also examined.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study compared inhibition in alcohol‐related and neutral contexts in patients with <jats:styled-content style="fixed-case">AUD</jats:styled-content> and healthy controls, while also taking into account the individual amount of craving. All subjects performed a Go/NoGo task involving neutral and alcohol‐related NoGo trials, while their brain activity was recorded using multichannel electroencephalography. The map strength and topography of the N2 and P3 components of the NoGo event‐related potentials were compared between groups and contexts using whole‐scalp randomization‐based methods. The effects of interest were further investigated with <jats:styled-content style="fixed-case">sLORETA</jats:styled-content> source analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the N2 component, the context by craving interaction was strong for map strength and map topography. The source analysis indicated that in subjects with high craving, alcohol‐related context led to enhanced and prolonged activation in the posterior cingulate and premotor cortical areas. This interaction was specific for craving, but not for diagnostic classification. The amplitude of the P3 component was reduced in subjects with <jats:styled-content style="fixed-case">AUD</jats:styled-content>, which replicated previous findings.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In subjects with strong craving, the conflict reflected in the NoGo‐N2 was enhanced in the alcohol‐related context. Such enhanced conflict probably makes the successful inhibition of the urge to drink in high‐risk situations even more difficult for this subgroup of patients and should therefore be addressed in individualized treatment planning.</jats:p></jats:sec> Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance Alcoholism: Clinical and Experimental Research |
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Psychologie Chemie und Pharmazie Medizin |
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Wiley, 2018 |
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| title |
Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_unstemmed |
Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_full |
Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_fullStr |
Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_full_unstemmed |
Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_short |
Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_sort |
context‐specific inhibition is related to craving in alcohol use disorders: a dangerous imbalance |
| topic |
Psychiatry and Mental health Toxicology Medicine (miscellaneous) |
| url |
http://dx.doi.org/10.1111/acer.13532 |
| publishDate |
2018 |
| physical |
69-80 |
| description |
<jats:sec><jats:title>Background</jats:title><jats:p>Most contemporary neuroscientific models of alcohol use disorders (<jats:styled-content style="fixed-case">AUD</jats:styled-content>) incorporate an imbalance between enhanced cue reactivity, which results in a strong urge to consume, and the impaired inhibitory control of that urge. While these phenomena have been frequently investigated separately, studies involving both aspects and thus precisely investigating the postulated imbalance are rare. In this study, inhibition was investigated in an addiction‐specific context and individual craving levels were also examined.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study compared inhibition in alcohol‐related and neutral contexts in patients with <jats:styled-content style="fixed-case">AUD</jats:styled-content> and healthy controls, while also taking into account the individual amount of craving. All subjects performed a Go/NoGo task involving neutral and alcohol‐related NoGo trials, while their brain activity was recorded using multichannel electroencephalography. The map strength and topography of the N2 and P3 components of the NoGo event‐related potentials were compared between groups and contexts using whole‐scalp randomization‐based methods. The effects of interest were further investigated with <jats:styled-content style="fixed-case">sLORETA</jats:styled-content> source analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the N2 component, the context by craving interaction was strong for map strength and map topography. The source analysis indicated that in subjects with high craving, alcohol‐related context led to enhanced and prolonged activation in the posterior cingulate and premotor cortical areas. This interaction was specific for craving, but not for diagnostic classification. The amplitude of the P3 component was reduced in subjects with <jats:styled-content style="fixed-case">AUD</jats:styled-content>, which replicated previous findings.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In subjects with strong craving, the conflict reflected in the NoGo‐N2 was enhanced in the alcohol‐related context. Such enhanced conflict probably makes the successful inhibition of the urge to drink in high‐risk situations even more difficult for this subgroup of patients and should therefore be addressed in individualized treatment planning.</jats:p></jats:sec> |
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| author | Stein, Maria, Fey, Werner, Koenig, Thomas, Oehy, Jacqueline, Moggi, Franz |
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| description | <jats:sec><jats:title>Background</jats:title><jats:p>Most contemporary neuroscientific models of alcohol use disorders (<jats:styled-content style="fixed-case">AUD</jats:styled-content>) incorporate an imbalance between enhanced cue reactivity, which results in a strong urge to consume, and the impaired inhibitory control of that urge. While these phenomena have been frequently investigated separately, studies involving both aspects and thus precisely investigating the postulated imbalance are rare. In this study, inhibition was investigated in an addiction‐specific context and individual craving levels were also examined.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study compared inhibition in alcohol‐related and neutral contexts in patients with <jats:styled-content style="fixed-case">AUD</jats:styled-content> and healthy controls, while also taking into account the individual amount of craving. All subjects performed a Go/NoGo task involving neutral and alcohol‐related NoGo trials, while their brain activity was recorded using multichannel electroencephalography. The map strength and topography of the N2 and P3 components of the NoGo event‐related potentials were compared between groups and contexts using whole‐scalp randomization‐based methods. The effects of interest were further investigated with <jats:styled-content style="fixed-case">sLORETA</jats:styled-content> source analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the N2 component, the context by craving interaction was strong for map strength and map topography. The source analysis indicated that in subjects with high craving, alcohol‐related context led to enhanced and prolonged activation in the posterior cingulate and premotor cortical areas. This interaction was specific for craving, but not for diagnostic classification. The amplitude of the P3 component was reduced in subjects with <jats:styled-content style="fixed-case">AUD</jats:styled-content>, which replicated previous findings.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In subjects with strong craving, the conflict reflected in the NoGo‐N2 was enhanced in the alcohol‐related context. Such enhanced conflict probably makes the successful inhibition of the urge to drink in high‐risk situations even more difficult for this subgroup of patients and should therefore be addressed in individualized treatment planning.</jats:p></jats:sec> |
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| spelling | Stein, Maria Fey, Werner Koenig, Thomas Oehy, Jacqueline Moggi, Franz 0145-6008 1530-0277 Wiley Psychiatry and Mental health Toxicology Medicine (miscellaneous) http://dx.doi.org/10.1111/acer.13532 <jats:sec><jats:title>Background</jats:title><jats:p>Most contemporary neuroscientific models of alcohol use disorders (<jats:styled-content style="fixed-case">AUD</jats:styled-content>) incorporate an imbalance between enhanced cue reactivity, which results in a strong urge to consume, and the impaired inhibitory control of that urge. While these phenomena have been frequently investigated separately, studies involving both aspects and thus precisely investigating the postulated imbalance are rare. In this study, inhibition was investigated in an addiction‐specific context and individual craving levels were also examined.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study compared inhibition in alcohol‐related and neutral contexts in patients with <jats:styled-content style="fixed-case">AUD</jats:styled-content> and healthy controls, while also taking into account the individual amount of craving. All subjects performed a Go/NoGo task involving neutral and alcohol‐related NoGo trials, while their brain activity was recorded using multichannel electroencephalography. The map strength and topography of the N2 and P3 components of the NoGo event‐related potentials were compared between groups and contexts using whole‐scalp randomization‐based methods. The effects of interest were further investigated with <jats:styled-content style="fixed-case">sLORETA</jats:styled-content> source analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the N2 component, the context by craving interaction was strong for map strength and map topography. The source analysis indicated that in subjects with high craving, alcohol‐related context led to enhanced and prolonged activation in the posterior cingulate and premotor cortical areas. This interaction was specific for craving, but not for diagnostic classification. The amplitude of the P3 component was reduced in subjects with <jats:styled-content style="fixed-case">AUD</jats:styled-content>, which replicated previous findings.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In subjects with strong craving, the conflict reflected in the NoGo‐N2 was enhanced in the alcohol‐related context. Such enhanced conflict probably makes the successful inhibition of the urge to drink in high‐risk situations even more difficult for this subgroup of patients and should therefore be addressed in individualized treatment planning.</jats:p></jats:sec> Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance Alcoholism: Clinical and Experimental Research |
| spellingShingle | Stein, Maria, Fey, Werner, Koenig, Thomas, Oehy, Jacqueline, Moggi, Franz, Alcoholism: Clinical and Experimental Research, Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance, Psychiatry and Mental health, Toxicology, Medicine (miscellaneous) |
| title | Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_full | Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_fullStr | Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_full_unstemmed | Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_short | Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| title_sort | context‐specific inhibition is related to craving in alcohol use disorders: a dangerous imbalance |
| title_unstemmed | Context‐Specific Inhibition is Related to Craving in Alcohol Use Disorders: A Dangerous Imbalance |
| topic | Psychiatry and Mental health, Toxicology, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1111/acer.13532 |