Eintrag weiter verarbeiten
Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer
Gespeichert in:
| Zeitschriftentitel: | Thoracic Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Thoracic Cancer, 10, 2019, 5, S. 1149-1157 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Xia, Wenjie Liu, Suyao Mao, Qixing Chen, Bing Ma, Weidong Dong, Gaochao Xu, Lin Jiang, Feng Xia, Wenjie Liu, Suyao Mao, Qixing Chen, Bing Ma, Weidong Dong, Gaochao Xu, Lin Jiang, Feng |
|---|---|
| author |
Xia, Wenjie Liu, Suyao Mao, Qixing Chen, Bing Ma, Weidong Dong, Gaochao Xu, Lin Jiang, Feng |
| spellingShingle |
Xia, Wenjie Liu, Suyao Mao, Qixing Chen, Bing Ma, Weidong Dong, Gaochao Xu, Lin Jiang, Feng Thoracic Cancer Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer Pulmonary and Respiratory Medicine Oncology General Medicine |
| author_sort |
xia, wenjie |
| spelling |
Xia, Wenjie Liu, Suyao Mao, Qixing Chen, Bing Ma, Weidong Dong, Gaochao Xu, Lin Jiang, Feng 1759-7706 1759-7714 Wiley Pulmonary and Respiratory Medicine Oncology General Medicine http://dx.doi.org/10.1111/1759-7714.13056 <jats:sec><jats:title>Background</jats:title><jats:p>We examined the association between numbers of lymph nodes examined (LNEs) and accurate staging and survival to determine the optimal LNE count during esophagectomy using data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry and the Department of Thoracic Surgery of a single institution (SI).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of 7356 EC patients met our inclusion criteria from the SEER database and 1275 patients from SI. We applied multivariate models to investigate the relationship between the LNE count and LN metastasis and cancer‐specific survival (CSS). Odds ratios (ORs) and hazard ratios (HRs) generated by the multivariate models were fitted with Locally Weighted Scatterplot Smoothing, and the structural breakpoints were determined by the Chow test.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Higher numbers of LNEs were linked to a higher proportion of LN metastasis and better CSS in both cohorts. Cut‐point analysis determined a threshold of LNEs of 12 for adenocarcinoma and 14 for esophageal squamous cell cancer (ESCC) considering accurate staging, and 15 for adenocarcinoma and 14 for ESCC considering OS. The cut‐points for CSS were examined in the SEER database and validated in the divided cohort from SI (all <jats:italic>P</jats:italic> < 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>A greater number of LNEs are significantly associated with more accurate N staging and better survival in EC patients. We recommend 15 and 14 as the threshold LNE counts for adenocarcinoma and ESCC patients, respectively.</jats:p></jats:sec> Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer Thoracic Cancer |
| doi_str_mv |
10.1111/1759-7714.13056 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS8xNzU5LTc3MTQuMTMwNTY |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS8xNzU5LTc3MTQuMTMwNTY |
| institution |
DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 |
| imprint |
Wiley, 2019 |
| imprint_str_mv |
Wiley, 2019 |
| issn |
1759-7706 1759-7714 |
| issn_str_mv |
1759-7706 1759-7714 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
xia2019effectoflymphnodeexaminedcountonaccuratestagingandsurvivalofresectedesophagealcancer |
| publishDateSort |
2019 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Thoracic Cancer |
| source_id |
49 |
| title |
Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_unstemmed |
Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_full |
Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_fullStr |
Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_full_unstemmed |
Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_short |
Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_sort |
effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| topic |
Pulmonary and Respiratory Medicine Oncology General Medicine |
| url |
http://dx.doi.org/10.1111/1759-7714.13056 |
| publishDate |
2019 |
| physical |
1149-1157 |
| description |
<jats:sec><jats:title>Background</jats:title><jats:p>We examined the association between numbers of lymph nodes examined (LNEs) and accurate staging and survival to determine the optimal LNE count during esophagectomy using data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry and the Department of Thoracic Surgery of a single institution (SI).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of 7356 EC patients met our inclusion criteria from the SEER database and 1275 patients from SI. We applied multivariate models to investigate the relationship between the LNE count and LN metastasis and cancer‐specific survival (CSS). Odds ratios (ORs) and hazard ratios (HRs) generated by the multivariate models were fitted with Locally Weighted Scatterplot Smoothing, and the structural breakpoints were determined by the Chow test.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Higher numbers of LNEs were linked to a higher proportion of LN metastasis and better CSS in both cohorts. Cut‐point analysis determined a threshold of LNEs of 12 for adenocarcinoma and 14 for esophageal squamous cell cancer (ESCC) considering accurate staging, and 15 for adenocarcinoma and 14 for ESCC considering OS. The cut‐points for CSS were examined in the SEER database and validated in the divided cohort from SI (all <jats:italic>P</jats:italic> < 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>A greater number of LNEs are significantly associated with more accurate N staging and better survival in EC patients. We recommend 15 and 14 as the threshold LNE counts for adenocarcinoma and ESCC patients, respectively.</jats:p></jats:sec> |
| container_issue |
5 |
| container_start_page |
1149 |
| container_title |
Thoracic Cancer |
| container_volume |
10 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336144723083281 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:55:13.749Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Effect+of+lymph+node+examined+count+on+accurate+staging+and+survival+of+resected+esophageal+cancer&rft.date=2019-05-01&genre=article&issn=1759-7714&volume=10&issue=5&spage=1149&epage=1157&pages=1149-1157&jtitle=Thoracic+Cancer&atitle=Effect+of+lymph+node+examined+count+on+accurate+staging+and+survival+of+resected+esophageal+cancer&aulast=Jiang&aufirst=Feng&rft_id=info%3Adoi%2F10.1111%2F1759-7714.13056&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336144723083281 |
| author | Xia, Wenjie, Liu, Suyao, Mao, Qixing, Chen, Bing, Ma, Weidong, Dong, Gaochao, Xu, Lin, Jiang, Feng |
| author_facet | Xia, Wenjie, Liu, Suyao, Mao, Qixing, Chen, Bing, Ma, Weidong, Dong, Gaochao, Xu, Lin, Jiang, Feng, Xia, Wenjie, Liu, Suyao, Mao, Qixing, Chen, Bing, Ma, Weidong, Dong, Gaochao, Xu, Lin, Jiang, Feng |
| author_sort | xia, wenjie |
| container_issue | 5 |
| container_start_page | 1149 |
| container_title | Thoracic Cancer |
| container_volume | 10 |
| description | <jats:sec><jats:title>Background</jats:title><jats:p>We examined the association between numbers of lymph nodes examined (LNEs) and accurate staging and survival to determine the optimal LNE count during esophagectomy using data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry and the Department of Thoracic Surgery of a single institution (SI).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of 7356 EC patients met our inclusion criteria from the SEER database and 1275 patients from SI. We applied multivariate models to investigate the relationship between the LNE count and LN metastasis and cancer‐specific survival (CSS). Odds ratios (ORs) and hazard ratios (HRs) generated by the multivariate models were fitted with Locally Weighted Scatterplot Smoothing, and the structural breakpoints were determined by the Chow test.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Higher numbers of LNEs were linked to a higher proportion of LN metastasis and better CSS in both cohorts. Cut‐point analysis determined a threshold of LNEs of 12 for adenocarcinoma and 14 for esophageal squamous cell cancer (ESCC) considering accurate staging, and 15 for adenocarcinoma and 14 for ESCC considering OS. The cut‐points for CSS were examined in the SEER database and validated in the divided cohort from SI (all <jats:italic>P</jats:italic> < 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>A greater number of LNEs are significantly associated with more accurate N staging and better survival in EC patients. We recommend 15 and 14 as the threshold LNE counts for adenocarcinoma and ESCC patients, respectively.</jats:p></jats:sec> |
| doi_str_mv | 10.1111/1759-7714.13056 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS8xNzU5LTc3MTQuMTMwNTY |
| imprint | Wiley, 2019 |
| imprint_str_mv | Wiley, 2019 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 1759-7706, 1759-7714 |
| issn_str_mv | 1759-7706, 1759-7714 |
| language | English |
| last_indexed | 2024-03-01T14:55:13.749Z |
| match_str | xia2019effectoflymphnodeexaminedcountonaccuratestagingandsurvivalofresectedesophagealcancer |
| mega_collection | Wiley (CrossRef) |
| physical | 1149-1157 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Thoracic Cancer |
| source_id | 49 |
| spelling | Xia, Wenjie Liu, Suyao Mao, Qixing Chen, Bing Ma, Weidong Dong, Gaochao Xu, Lin Jiang, Feng 1759-7706 1759-7714 Wiley Pulmonary and Respiratory Medicine Oncology General Medicine http://dx.doi.org/10.1111/1759-7714.13056 <jats:sec><jats:title>Background</jats:title><jats:p>We examined the association between numbers of lymph nodes examined (LNEs) and accurate staging and survival to determine the optimal LNE count during esophagectomy using data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry and the Department of Thoracic Surgery of a single institution (SI).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of 7356 EC patients met our inclusion criteria from the SEER database and 1275 patients from SI. We applied multivariate models to investigate the relationship between the LNE count and LN metastasis and cancer‐specific survival (CSS). Odds ratios (ORs) and hazard ratios (HRs) generated by the multivariate models were fitted with Locally Weighted Scatterplot Smoothing, and the structural breakpoints were determined by the Chow test.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Higher numbers of LNEs were linked to a higher proportion of LN metastasis and better CSS in both cohorts. Cut‐point analysis determined a threshold of LNEs of 12 for adenocarcinoma and 14 for esophageal squamous cell cancer (ESCC) considering accurate staging, and 15 for adenocarcinoma and 14 for ESCC considering OS. The cut‐points for CSS were examined in the SEER database and validated in the divided cohort from SI (all <jats:italic>P</jats:italic> < 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>A greater number of LNEs are significantly associated with more accurate N staging and better survival in EC patients. We recommend 15 and 14 as the threshold LNE counts for adenocarcinoma and ESCC patients, respectively.</jats:p></jats:sec> Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer Thoracic Cancer |
| spellingShingle | Xia, Wenjie, Liu, Suyao, Mao, Qixing, Chen, Bing, Ma, Weidong, Dong, Gaochao, Xu, Lin, Jiang, Feng, Thoracic Cancer, Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer, Pulmonary and Respiratory Medicine, Oncology, General Medicine |
| title | Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_full | Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_fullStr | Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_full_unstemmed | Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_short | Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_sort | effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| title_unstemmed | Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer |
| topic | Pulmonary and Respiratory Medicine, Oncology, General Medicine |
| url | http://dx.doi.org/10.1111/1759-7714.13056 |