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The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis...
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| Zeitschriftentitel: | Environmental Microbiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Environmental Microbiology, 17, 2015, 11, S. 4631-4645 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Song, Yunhong Xiao, Xiao Li, Changfu Wang, Tietao Zhao, Ruoxi Zhang, Weipeng Zhang, Lei Wang, Yao Shen, Xihui Song, Yunhong Xiao, Xiao Li, Changfu Wang, Tietao Zhao, Ruoxi Zhang, Weipeng Zhang, Lei Wang, Yao Shen, Xihui |
|---|---|
| author |
Song, Yunhong Xiao, Xiao Li, Changfu Wang, Tietao Zhao, Ruoxi Zhang, Weipeng Zhang, Lei Wang, Yao Shen, Xihui |
| spellingShingle |
Song, Yunhong Xiao, Xiao Li, Changfu Wang, Tietao Zhao, Ruoxi Zhang, Weipeng Zhang, Lei Wang, Yao Shen, Xihui Environmental Microbiology The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis Ecology, Evolution, Behavior and Systematics Microbiology |
| author_sort |
song, yunhong |
| spelling |
Song, Yunhong Xiao, Xiao Li, Changfu Wang, Tietao Zhao, Ruoxi Zhang, Weipeng Zhang, Lei Wang, Yao Shen, Xihui 1462-2912 1462-2920 Wiley Ecology, Evolution, Behavior and Systematics Microbiology http://dx.doi.org/10.1111/1462-2920.12996 <jats:title>Summary</jats:title><jats:p>Coordinated regulation of various acid survival systems in response to environmental stimuli is crucial for the adaptation of enteropathogenic bacteria to acidic environments such as the stomach. In this study, we demonstrated that the <jats:styled-content style="fixed-case">RovM</jats:styled-content> protein, a central regulator of the <jats:styled-content style="fixed-case">CsrABC</jats:styled-content>‐<jats:styled-content style="fixed-case">RovM</jats:styled-content>‐<jats:styled-content style="fixed-case">RovA</jats:styled-content> cascade, conversely regulates the expression of two acid survival systems in <jats:styled-content style="fixed-case"><jats:italic>Y</jats:italic></jats:styled-content><jats:italic>ersinia pseudotuberculosis</jats:italic> by acting as a dual transcriptional regulator. <jats:styled-content style="fixed-case">RovM</jats:styled-content> activated the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content>, which is essential for bacterial survival under mild acidic conditions, by binding upstream of the <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> promoter. On the contrary, <jats:styled-content style="fixed-case">RovM</jats:styled-content> repressed the expression of a functional arginine‐dependent acid resistance system (<jats:styled-content style="fixed-case">AR3</jats:styled-content>), which is crucial for bacterial survival under strong acidic conditions, by directly binding to the −35 element in the <jats:styled-content style="fixed-case">AR3</jats:styled-content> promoter. Consistent with previous findings that <jats:italic>rovM</jats:italic> expression responds to the availability of nutrients, the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> and <jats:styled-content style="fixed-case">AR3</jats:styled-content> was differentially regulated by nutritional status. Based on these results, a dynamic model whereby <jats:styled-content style="fixed-case">RovM</jats:styled-content> coordinately regulates the expression of <jats:styled-content style="fixed-case">AR3</jats:styled-content> and <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> in response to the availability of nutrients in the environment was proposed.</jats:p> The dual transcriptional regulator <scp>RovM</scp> regulates the expression of <scp>AR3</scp>‐ and <scp>T6SS4</scp>‐dependent acid survival systems in response to nutritional status in <scp><i>Y</i></scp><i>ersinia pseudotuberculosis</i> Environmental Microbiology |
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10.1111/1462-2920.12996 |
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Online |
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Geographie Biologie |
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Wiley, 2015 |
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Wiley, 2015 |
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1462-2920 1462-2912 |
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2015 |
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Wiley |
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Environmental Microbiology |
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49 |
| title |
The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_unstemmed |
The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_full |
The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_fullStr |
The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_full_unstemmed |
The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_short |
The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_sort |
the dual transcriptional regulator <scp>rovm</scp> regulates the expression of <scp>ar3</scp>‐ and <scp>t6ss4</scp>‐dependent acid survival systems in response to nutritional status in <scp><i>y</i></scp><i>ersinia pseudotuberculosis</i> |
| topic |
Ecology, Evolution, Behavior and Systematics Microbiology |
| url |
http://dx.doi.org/10.1111/1462-2920.12996 |
| publishDate |
2015 |
| physical |
4631-4645 |
| description |
<jats:title>Summary</jats:title><jats:p>Coordinated regulation of various acid survival systems in response to environmental stimuli is crucial for the adaptation of enteropathogenic bacteria to acidic environments such as the stomach. In this study, we demonstrated that the <jats:styled-content style="fixed-case">RovM</jats:styled-content> protein, a central regulator of the <jats:styled-content style="fixed-case">CsrABC</jats:styled-content>‐<jats:styled-content style="fixed-case">RovM</jats:styled-content>‐<jats:styled-content style="fixed-case">RovA</jats:styled-content> cascade, conversely regulates the expression of two acid survival systems in <jats:styled-content style="fixed-case"><jats:italic>Y</jats:italic></jats:styled-content><jats:italic>ersinia pseudotuberculosis</jats:italic> by acting as a dual transcriptional regulator. <jats:styled-content style="fixed-case">RovM</jats:styled-content> activated the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content>, which is essential for bacterial survival under mild acidic conditions, by binding upstream of the <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> promoter. On the contrary, <jats:styled-content style="fixed-case">RovM</jats:styled-content> repressed the expression of a functional arginine‐dependent acid resistance system (<jats:styled-content style="fixed-case">AR3</jats:styled-content>), which is crucial for bacterial survival under strong acidic conditions, by directly binding to the −35 element in the <jats:styled-content style="fixed-case">AR3</jats:styled-content> promoter. Consistent with previous findings that <jats:italic>rovM</jats:italic> expression responds to the availability of nutrients, the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> and <jats:styled-content style="fixed-case">AR3</jats:styled-content> was differentially regulated by nutritional status. Based on these results, a dynamic model whereby <jats:styled-content style="fixed-case">RovM</jats:styled-content> coordinately regulates the expression of <jats:styled-content style="fixed-case">AR3</jats:styled-content> and <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> in response to the availability of nutrients in the environment was proposed.</jats:p> |
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| author | Song, Yunhong, Xiao, Xiao, Li, Changfu, Wang, Tietao, Zhao, Ruoxi, Zhang, Weipeng, Zhang, Lei, Wang, Yao, Shen, Xihui |
| author_facet | Song, Yunhong, Xiao, Xiao, Li, Changfu, Wang, Tietao, Zhao, Ruoxi, Zhang, Weipeng, Zhang, Lei, Wang, Yao, Shen, Xihui, Song, Yunhong, Xiao, Xiao, Li, Changfu, Wang, Tietao, Zhao, Ruoxi, Zhang, Weipeng, Zhang, Lei, Wang, Yao, Shen, Xihui |
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| description | <jats:title>Summary</jats:title><jats:p>Coordinated regulation of various acid survival systems in response to environmental stimuli is crucial for the adaptation of enteropathogenic bacteria to acidic environments such as the stomach. In this study, we demonstrated that the <jats:styled-content style="fixed-case">RovM</jats:styled-content> protein, a central regulator of the <jats:styled-content style="fixed-case">CsrABC</jats:styled-content>‐<jats:styled-content style="fixed-case">RovM</jats:styled-content>‐<jats:styled-content style="fixed-case">RovA</jats:styled-content> cascade, conversely regulates the expression of two acid survival systems in <jats:styled-content style="fixed-case"><jats:italic>Y</jats:italic></jats:styled-content><jats:italic>ersinia pseudotuberculosis</jats:italic> by acting as a dual transcriptional regulator. <jats:styled-content style="fixed-case">RovM</jats:styled-content> activated the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content>, which is essential for bacterial survival under mild acidic conditions, by binding upstream of the <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> promoter. On the contrary, <jats:styled-content style="fixed-case">RovM</jats:styled-content> repressed the expression of a functional arginine‐dependent acid resistance system (<jats:styled-content style="fixed-case">AR3</jats:styled-content>), which is crucial for bacterial survival under strong acidic conditions, by directly binding to the −35 element in the <jats:styled-content style="fixed-case">AR3</jats:styled-content> promoter. Consistent with previous findings that <jats:italic>rovM</jats:italic> expression responds to the availability of nutrients, the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> and <jats:styled-content style="fixed-case">AR3</jats:styled-content> was differentially regulated by nutritional status. Based on these results, a dynamic model whereby <jats:styled-content style="fixed-case">RovM</jats:styled-content> coordinately regulates the expression of <jats:styled-content style="fixed-case">AR3</jats:styled-content> and <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> in response to the availability of nutrients in the environment was proposed.</jats:p> |
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| spelling | Song, Yunhong Xiao, Xiao Li, Changfu Wang, Tietao Zhao, Ruoxi Zhang, Weipeng Zhang, Lei Wang, Yao Shen, Xihui 1462-2912 1462-2920 Wiley Ecology, Evolution, Behavior and Systematics Microbiology http://dx.doi.org/10.1111/1462-2920.12996 <jats:title>Summary</jats:title><jats:p>Coordinated regulation of various acid survival systems in response to environmental stimuli is crucial for the adaptation of enteropathogenic bacteria to acidic environments such as the stomach. In this study, we demonstrated that the <jats:styled-content style="fixed-case">RovM</jats:styled-content> protein, a central regulator of the <jats:styled-content style="fixed-case">CsrABC</jats:styled-content>‐<jats:styled-content style="fixed-case">RovM</jats:styled-content>‐<jats:styled-content style="fixed-case">RovA</jats:styled-content> cascade, conversely regulates the expression of two acid survival systems in <jats:styled-content style="fixed-case"><jats:italic>Y</jats:italic></jats:styled-content><jats:italic>ersinia pseudotuberculosis</jats:italic> by acting as a dual transcriptional regulator. <jats:styled-content style="fixed-case">RovM</jats:styled-content> activated the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content>, which is essential for bacterial survival under mild acidic conditions, by binding upstream of the <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> promoter. On the contrary, <jats:styled-content style="fixed-case">RovM</jats:styled-content> repressed the expression of a functional arginine‐dependent acid resistance system (<jats:styled-content style="fixed-case">AR3</jats:styled-content>), which is crucial for bacterial survival under strong acidic conditions, by directly binding to the −35 element in the <jats:styled-content style="fixed-case">AR3</jats:styled-content> promoter. Consistent with previous findings that <jats:italic>rovM</jats:italic> expression responds to the availability of nutrients, the expression of <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> and <jats:styled-content style="fixed-case">AR3</jats:styled-content> was differentially regulated by nutritional status. Based on these results, a dynamic model whereby <jats:styled-content style="fixed-case">RovM</jats:styled-content> coordinately regulates the expression of <jats:styled-content style="fixed-case">AR3</jats:styled-content> and <jats:styled-content style="fixed-case">T6SS4</jats:styled-content> in response to the availability of nutrients in the environment was proposed.</jats:p> The dual transcriptional regulator <scp>RovM</scp> regulates the expression of <scp>AR3</scp>‐ and <scp>T6SS4</scp>‐dependent acid survival systems in response to nutritional status in <scp><i>Y</i></scp><i>ersinia pseudotuberculosis</i> Environmental Microbiology |
| spellingShingle | Song, Yunhong, Xiao, Xiao, Li, Changfu, Wang, Tietao, Zhao, Ruoxi, Zhang, Weipeng, Zhang, Lei, Wang, Yao, Shen, Xihui, Environmental Microbiology, The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis, Ecology, Evolution, Behavior and Systematics, Microbiology |
| title | The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_full | The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_fullStr | The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_full_unstemmed | The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_short | The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| title_sort | the dual transcriptional regulator <scp>rovm</scp> regulates the expression of <scp>ar3</scp>‐ and <scp>t6ss4</scp>‐dependent acid survival systems in response to nutritional status in <scp><i>y</i></scp><i>ersinia pseudotuberculosis</i> |
| title_unstemmed | The dual transcriptional regulator RovM regulates the expression of AR3‐ and T6SS4‐dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis |
| topic | Ecology, Evolution, Behavior and Systematics, Microbiology |
| url | http://dx.doi.org/10.1111/1462-2920.12996 |