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Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia
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| Zeitschriftentitel: | Clinical and Experimental Pharmacology and Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Clinical and Experimental Pharmacology and Physiology, 41, 2014, 6, S. 400-407 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
He, Hui Xu, Ya‐Jing Yin, Ji‐Ye Li, Xi Qu, Jian Xu, Xiao‐Jing Liu, Zhuo‐Gang Zhou, Fan Zhai, Ming Li, Yan Zhou, Hong‐Hao Liu, Zhao‐Qian He, Hui Xu, Ya‐Jing Yin, Ji‐Ye Li, Xi Qu, Jian Xu, Xiao‐Jing Liu, Zhuo‐Gang Zhou, Fan Zhai, Ming Li, Yan Zhou, Hong‐Hao Liu, Zhao‐Qian |
|---|---|
| author |
He, Hui Xu, Ya‐Jing Yin, Ji‐Ye Li, Xi Qu, Jian Xu, Xiao‐Jing Liu, Zhuo‐Gang Zhou, Fan Zhai, Ming Li, Yan Zhou, Hong‐Hao Liu, Zhao‐Qian |
| spellingShingle |
He, Hui Xu, Ya‐Jing Yin, Ji‐Ye Li, Xi Qu, Jian Xu, Xiao‐Jing Liu, Zhuo‐Gang Zhou, Fan Zhai, Ming Li, Yan Zhou, Hong‐Hao Liu, Zhao‐Qian Clinical and Experimental Pharmacology and Physiology Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia Physiology (medical) Pharmacology Physiology |
| author_sort |
he, hui |
| spelling |
He, Hui Xu, Ya‐Jing Yin, Ji‐Ye Li, Xi Qu, Jian Xu, Xiao‐Jing Liu, Zhuo‐Gang Zhou, Fan Zhai, Ming Li, Yan Zhou, Hong‐Hao Liu, Zhao‐Qian 0305-1870 1440-1681 Wiley Physiology (medical) Pharmacology Physiology http://dx.doi.org/10.1111/1440-1681.12235 <jats:title>Summary</jats:title><jats:p>The aim of the present study was to investigate the influence of the nitric oxide synthase 3 (<jats:italic>NOS3</jats:italic>) 894 G>T polymorphism on prognostic outcomes of anthracycline in Chinese patients with <jats:italic>de novo</jats:italic> intermediate‐risk acute myeloid leukaemia (AML) and to examine the gene expression level in relation to genetic variation. In all, 225 Chinese patients with intermediate‐risk AML (at the complete remission stage) treated with anthracycline were enrolled in the study. The 894 G>T polymorphism of the <jats:italic>NOS3</jats:italic> gene was analysed by allele‐specific matrix‐assisted laser desorption ionization time‐of‐flight. Expression of <jats:italic>NOS3 </jats:italic><jats:styled-content style="fixed-case">mRNA</jats:styled-content> was tested in 72 patients of known genotype for <jats:italic>NOS3</jats:italic> 894 G>T. The clinical characteristics of these patients were obtained from medical records. Survival analysis showed that patients with AML (GG genotype) had a longer overall survival (OS; <jats:italic>P = </jats:italic>0.006). After adjusting for age, gender, leucocyte count, haemoglobin level, platelet level, French, American and Britain (FAB) classification, lactate dehydrogenase levels, Eastern Cooperative Oncology Group Performance Status, nucleophosmin gene and fms‐related tyrosine kinase 3 gene, multivariate survival analysis showed that the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism appeared to be a predicting factor for OS (<jats:italic>P = </jats:italic>0.014; hazard ratio = 1.856). However, no significant associations between the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism and relapse‐free survival and relapse in patients with AML were observed. Gene expression levels were significantly higher in patients with the GG genotype than in patients with the GT and TT genotypes (<jats:italic>P = </jats:italic>0.033). The findings suggest that the <jats:italic>NOS3</jats:italic> 894 G>T variant may be a biomarker for the prediction of OS in Chinese patients with AML.</jats:p> Association of nitric oxide synthase 3 (<i>NOS3</i>) 894 G>T polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia Clinical and Experimental Pharmacology and Physiology |
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10.1111/1440-1681.12235 |
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Wiley, 2014 |
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Wiley, 2014 |
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| title |
Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_unstemmed |
Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_full |
Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_fullStr |
Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_full_unstemmed |
Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_short |
Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_sort |
association of nitric oxide synthase 3 (<i>nos3</i>) 894 g>t polymorphism with prognostic outcomes of anthracycline in chinese patients with acute myeloid leukaemia |
| topic |
Physiology (medical) Pharmacology Physiology |
| url |
http://dx.doi.org/10.1111/1440-1681.12235 |
| publishDate |
2014 |
| physical |
400-407 |
| description |
<jats:title>Summary</jats:title><jats:p>The aim of the present study was to investigate the influence of the nitric oxide synthase 3 (<jats:italic>NOS3</jats:italic>) 894 G>T polymorphism on prognostic outcomes of anthracycline in Chinese patients with <jats:italic>de novo</jats:italic> intermediate‐risk acute myeloid leukaemia (AML) and to examine the gene expression level in relation to genetic variation. In all, 225 Chinese patients with intermediate‐risk AML (at the complete remission stage) treated with anthracycline were enrolled in the study. The 894 G>T polymorphism of the <jats:italic>NOS3</jats:italic> gene was analysed by allele‐specific matrix‐assisted laser desorption ionization time‐of‐flight. Expression of <jats:italic>NOS3 </jats:italic><jats:styled-content style="fixed-case">mRNA</jats:styled-content> was tested in 72 patients of known genotype for <jats:italic>NOS3</jats:italic> 894 G>T. The clinical characteristics of these patients were obtained from medical records. Survival analysis showed that patients with AML (GG genotype) had a longer overall survival (OS; <jats:italic>P = </jats:italic>0.006). After adjusting for age, gender, leucocyte count, haemoglobin level, platelet level, French, American and Britain (FAB) classification, lactate dehydrogenase levels, Eastern Cooperative Oncology Group Performance Status, nucleophosmin gene and fms‐related tyrosine kinase 3 gene, multivariate survival analysis showed that the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism appeared to be a predicting factor for OS (<jats:italic>P = </jats:italic>0.014; hazard ratio = 1.856). However, no significant associations between the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism and relapse‐free survival and relapse in patients with AML were observed. Gene expression levels were significantly higher in patients with the GG genotype than in patients with the GT and TT genotypes (<jats:italic>P = </jats:italic>0.033). The findings suggest that the <jats:italic>NOS3</jats:italic> 894 G>T variant may be a biomarker for the prediction of OS in Chinese patients with AML.</jats:p> |
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| author | He, Hui, Xu, Ya‐Jing, Yin, Ji‐Ye, Li, Xi, Qu, Jian, Xu, Xiao‐Jing, Liu, Zhuo‐Gang, Zhou, Fan, Zhai, Ming, Li, Yan, Zhou, Hong‐Hao, Liu, Zhao‐Qian |
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| description | <jats:title>Summary</jats:title><jats:p>The aim of the present study was to investigate the influence of the nitric oxide synthase 3 (<jats:italic>NOS3</jats:italic>) 894 G>T polymorphism on prognostic outcomes of anthracycline in Chinese patients with <jats:italic>de novo</jats:italic> intermediate‐risk acute myeloid leukaemia (AML) and to examine the gene expression level in relation to genetic variation. In all, 225 Chinese patients with intermediate‐risk AML (at the complete remission stage) treated with anthracycline were enrolled in the study. The 894 G>T polymorphism of the <jats:italic>NOS3</jats:italic> gene was analysed by allele‐specific matrix‐assisted laser desorption ionization time‐of‐flight. Expression of <jats:italic>NOS3 </jats:italic><jats:styled-content style="fixed-case">mRNA</jats:styled-content> was tested in 72 patients of known genotype for <jats:italic>NOS3</jats:italic> 894 G>T. The clinical characteristics of these patients were obtained from medical records. Survival analysis showed that patients with AML (GG genotype) had a longer overall survival (OS; <jats:italic>P = </jats:italic>0.006). After adjusting for age, gender, leucocyte count, haemoglobin level, platelet level, French, American and Britain (FAB) classification, lactate dehydrogenase levels, Eastern Cooperative Oncology Group Performance Status, nucleophosmin gene and fms‐related tyrosine kinase 3 gene, multivariate survival analysis showed that the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism appeared to be a predicting factor for OS (<jats:italic>P = </jats:italic>0.014; hazard ratio = 1.856). However, no significant associations between the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism and relapse‐free survival and relapse in patients with AML were observed. Gene expression levels were significantly higher in patients with the GG genotype than in patients with the GT and TT genotypes (<jats:italic>P = </jats:italic>0.033). The findings suggest that the <jats:italic>NOS3</jats:italic> 894 G>T variant may be a biomarker for the prediction of OS in Chinese patients with AML.</jats:p> |
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| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161 |
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| spelling | He, Hui Xu, Ya‐Jing Yin, Ji‐Ye Li, Xi Qu, Jian Xu, Xiao‐Jing Liu, Zhuo‐Gang Zhou, Fan Zhai, Ming Li, Yan Zhou, Hong‐Hao Liu, Zhao‐Qian 0305-1870 1440-1681 Wiley Physiology (medical) Pharmacology Physiology http://dx.doi.org/10.1111/1440-1681.12235 <jats:title>Summary</jats:title><jats:p>The aim of the present study was to investigate the influence of the nitric oxide synthase 3 (<jats:italic>NOS3</jats:italic>) 894 G>T polymorphism on prognostic outcomes of anthracycline in Chinese patients with <jats:italic>de novo</jats:italic> intermediate‐risk acute myeloid leukaemia (AML) and to examine the gene expression level in relation to genetic variation. In all, 225 Chinese patients with intermediate‐risk AML (at the complete remission stage) treated with anthracycline were enrolled in the study. The 894 G>T polymorphism of the <jats:italic>NOS3</jats:italic> gene was analysed by allele‐specific matrix‐assisted laser desorption ionization time‐of‐flight. Expression of <jats:italic>NOS3 </jats:italic><jats:styled-content style="fixed-case">mRNA</jats:styled-content> was tested in 72 patients of known genotype for <jats:italic>NOS3</jats:italic> 894 G>T. The clinical characteristics of these patients were obtained from medical records. Survival analysis showed that patients with AML (GG genotype) had a longer overall survival (OS; <jats:italic>P = </jats:italic>0.006). After adjusting for age, gender, leucocyte count, haemoglobin level, platelet level, French, American and Britain (FAB) classification, lactate dehydrogenase levels, Eastern Cooperative Oncology Group Performance Status, nucleophosmin gene and fms‐related tyrosine kinase 3 gene, multivariate survival analysis showed that the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism appeared to be a predicting factor for OS (<jats:italic>P = </jats:italic>0.014; hazard ratio = 1.856). However, no significant associations between the <jats:italic>NOS3</jats:italic> 894 G>T polymorphism and relapse‐free survival and relapse in patients with AML were observed. Gene expression levels were significantly higher in patients with the GG genotype than in patients with the GT and TT genotypes (<jats:italic>P = </jats:italic>0.033). The findings suggest that the <jats:italic>NOS3</jats:italic> 894 G>T variant may be a biomarker for the prediction of OS in Chinese patients with AML.</jats:p> Association of nitric oxide synthase 3 (<i>NOS3</i>) 894 G>T polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia Clinical and Experimental Pharmacology and Physiology |
| spellingShingle | He, Hui, Xu, Ya‐Jing, Yin, Ji‐Ye, Li, Xi, Qu, Jian, Xu, Xiao‐Jing, Liu, Zhuo‐Gang, Zhou, Fan, Zhai, Ming, Li, Yan, Zhou, Hong‐Hao, Liu, Zhao‐Qian, Clinical and Experimental Pharmacology and Physiology, Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia, Physiology (medical), Pharmacology, Physiology |
| title | Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_full | Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_fullStr | Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_full_unstemmed | Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_short | Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| title_sort | association of nitric oxide synthase 3 (<i>nos3</i>) 894 g>t polymorphism with prognostic outcomes of anthracycline in chinese patients with acute myeloid leukaemia |
| title_unstemmed | Association of nitric oxide synthase 3 (NOS3) 894 GT polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia |
| topic | Physiology (medical), Pharmacology, Physiology |
| url | http://dx.doi.org/10.1111/1440-1681.12235 |