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Acute intermittent hypoxia induced neural plasticity in respiratory motor control
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| Zeitschriftentitel: | Clinical and Experimental Pharmacology and Physiology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Clinical and Experimental Pharmacology and Physiology, 40, 2013, 9, S. 602-609 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Xing, Tao Fong, Angelina Y Bautista, Tara G Pilowsky, Paul M Xing, Tao Fong, Angelina Y Bautista, Tara G Pilowsky, Paul M |
|---|---|
| author |
Xing, Tao Fong, Angelina Y Bautista, Tara G Pilowsky, Paul M |
| spellingShingle |
Xing, Tao Fong, Angelina Y Bautista, Tara G Pilowsky, Paul M Clinical and Experimental Pharmacology and Physiology Acute intermittent hypoxia induced neural plasticity in respiratory motor control Physiology (medical) Pharmacology Physiology |
| author_sort |
xing, tao |
| spelling |
Xing, Tao Fong, Angelina Y Bautista, Tara G Pilowsky, Paul M 0305-1870 1440-1681 Wiley Physiology (medical) Pharmacology Physiology http://dx.doi.org/10.1111/1440-1681.12129 <jats:title>Summary</jats:title><jats:p> <jats:list> <jats:list-item><jats:p>Respiratory neural networks can adapt to rapid environmental change or be altered over the long term by various inputs. The mechanisms that underlie the plasticity necessary for adaptive changes in breathing remain unclear. Acute intermittent hypoxia (<jats:styled-content style="fixed-case">AIH</jats:styled-content>)‐induced respiratory long‐term facilitation (<jats:styled-content style="fixed-case">LTF</jats:styled-content>) is one of the most extensively studied types of respiratory plasticity.</jats:p></jats:list-item> <jats:list-item><jats:p>Acute intermittent hypoxia‐induced <jats:styled-content style="fixed-case">LTF</jats:styled-content> is present in several respiratory motor outputs, innervating both pump muscles (i.e. diaphragm) and valve muscles (i.e. tongue, pharynx and larynx). Long‐term facilitation is present in various species, including humans, and the expression of <jats:styled-content style="fixed-case">LTF</jats:styled-content> is influenced by gender, age and genetics.</jats:p></jats:list-item> <jats:list-item><jats:p>Serotonin plays a key role in initiating and modulating plasticity at the level of respiratory motor neurons. Recently, multiple intracellular pathways have been elucidated that are capable of giving rise to respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content>. These mainly activate the metabolic receptors coupled to G<jats:sub>q</jats:sub> (‘Q’ pathway) and G<jats:sub>s</jats:sub> (‘S’ pathway) proteins.</jats:p></jats:list-item> <jats:list-item><jats:p>Herein, we discuss <jats:styled-content style="fixed-case">AIH</jats:styled-content>‐induced respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content> in animals and humans, as well as recent advances in our understanding of the synaptic and intracellular pathways underlying this form of plasticity. We also discuss the potential to use intermittent hypoxia to induce functional recovery following cervical spinal injury.</jats:p></jats:list-item> </jats:list> </jats:p> Acute intermittent hypoxia induced neural plasticity in respiratory motor control Clinical and Experimental Pharmacology and Physiology |
| doi_str_mv |
10.1111/1440-1681.12129 |
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Online |
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Biologie Chemie und Pharmazie |
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Wiley, 2013 |
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2013 |
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Clinical and Experimental Pharmacology and Physiology |
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| title |
Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_unstemmed |
Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_full |
Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_fullStr |
Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_full_unstemmed |
Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_short |
Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_sort |
acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| topic |
Physiology (medical) Pharmacology Physiology |
| url |
http://dx.doi.org/10.1111/1440-1681.12129 |
| publishDate |
2013 |
| physical |
602-609 |
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<jats:title>Summary</jats:title><jats:p>
<jats:list>
<jats:list-item><jats:p>Respiratory neural networks can adapt to rapid environmental change or be altered over the long term by various inputs. The mechanisms that underlie the plasticity necessary for adaptive changes in breathing remain unclear. Acute intermittent hypoxia (<jats:styled-content style="fixed-case">AIH</jats:styled-content>)‐induced respiratory long‐term facilitation (<jats:styled-content style="fixed-case">LTF</jats:styled-content>) is one of the most extensively studied types of respiratory plasticity.</jats:p></jats:list-item>
<jats:list-item><jats:p>Acute intermittent hypoxia‐induced <jats:styled-content style="fixed-case">LTF</jats:styled-content> is present in several respiratory motor outputs, innervating both pump muscles (i.e. diaphragm) and valve muscles (i.e. tongue, pharynx and larynx). Long‐term facilitation is present in various species, including humans, and the expression of <jats:styled-content style="fixed-case">LTF</jats:styled-content> is influenced by gender, age and genetics.</jats:p></jats:list-item>
<jats:list-item><jats:p>Serotonin plays a key role in initiating and modulating plasticity at the level of respiratory motor neurons. Recently, multiple intracellular pathways have been elucidated that are capable of giving rise to respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content>. These mainly activate the metabolic receptors coupled to G<jats:sub>q</jats:sub> (‘Q’ pathway) and G<jats:sub>s</jats:sub> (‘S’ pathway) proteins.</jats:p></jats:list-item>
<jats:list-item><jats:p>Herein, we discuss <jats:styled-content style="fixed-case">AIH</jats:styled-content>‐induced respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content> in animals and humans, as well as recent advances in our understanding of the synaptic and intracellular pathways underlying this form of plasticity. We also discuss the potential to use intermittent hypoxia to induce functional recovery following cervical spinal injury.</jats:p></jats:list-item>
</jats:list>
</jats:p> |
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| author | Xing, Tao, Fong, Angelina Y, Bautista, Tara G, Pilowsky, Paul M |
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| description | <jats:title>Summary</jats:title><jats:p> <jats:list> <jats:list-item><jats:p>Respiratory neural networks can adapt to rapid environmental change or be altered over the long term by various inputs. The mechanisms that underlie the plasticity necessary for adaptive changes in breathing remain unclear. Acute intermittent hypoxia (<jats:styled-content style="fixed-case">AIH</jats:styled-content>)‐induced respiratory long‐term facilitation (<jats:styled-content style="fixed-case">LTF</jats:styled-content>) is one of the most extensively studied types of respiratory plasticity.</jats:p></jats:list-item> <jats:list-item><jats:p>Acute intermittent hypoxia‐induced <jats:styled-content style="fixed-case">LTF</jats:styled-content> is present in several respiratory motor outputs, innervating both pump muscles (i.e. diaphragm) and valve muscles (i.e. tongue, pharynx and larynx). Long‐term facilitation is present in various species, including humans, and the expression of <jats:styled-content style="fixed-case">LTF</jats:styled-content> is influenced by gender, age and genetics.</jats:p></jats:list-item> <jats:list-item><jats:p>Serotonin plays a key role in initiating and modulating plasticity at the level of respiratory motor neurons. Recently, multiple intracellular pathways have been elucidated that are capable of giving rise to respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content>. These mainly activate the metabolic receptors coupled to G<jats:sub>q</jats:sub> (‘Q’ pathway) and G<jats:sub>s</jats:sub> (‘S’ pathway) proteins.</jats:p></jats:list-item> <jats:list-item><jats:p>Herein, we discuss <jats:styled-content style="fixed-case">AIH</jats:styled-content>‐induced respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content> in animals and humans, as well as recent advances in our understanding of the synaptic and intracellular pathways underlying this form of plasticity. We also discuss the potential to use intermittent hypoxia to induce functional recovery following cervical spinal injury.</jats:p></jats:list-item> </jats:list> </jats:p> |
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| spelling | Xing, Tao Fong, Angelina Y Bautista, Tara G Pilowsky, Paul M 0305-1870 1440-1681 Wiley Physiology (medical) Pharmacology Physiology http://dx.doi.org/10.1111/1440-1681.12129 <jats:title>Summary</jats:title><jats:p> <jats:list> <jats:list-item><jats:p>Respiratory neural networks can adapt to rapid environmental change or be altered over the long term by various inputs. The mechanisms that underlie the plasticity necessary for adaptive changes in breathing remain unclear. Acute intermittent hypoxia (<jats:styled-content style="fixed-case">AIH</jats:styled-content>)‐induced respiratory long‐term facilitation (<jats:styled-content style="fixed-case">LTF</jats:styled-content>) is one of the most extensively studied types of respiratory plasticity.</jats:p></jats:list-item> <jats:list-item><jats:p>Acute intermittent hypoxia‐induced <jats:styled-content style="fixed-case">LTF</jats:styled-content> is present in several respiratory motor outputs, innervating both pump muscles (i.e. diaphragm) and valve muscles (i.e. tongue, pharynx and larynx). Long‐term facilitation is present in various species, including humans, and the expression of <jats:styled-content style="fixed-case">LTF</jats:styled-content> is influenced by gender, age and genetics.</jats:p></jats:list-item> <jats:list-item><jats:p>Serotonin plays a key role in initiating and modulating plasticity at the level of respiratory motor neurons. Recently, multiple intracellular pathways have been elucidated that are capable of giving rise to respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content>. These mainly activate the metabolic receptors coupled to G<jats:sub>q</jats:sub> (‘Q’ pathway) and G<jats:sub>s</jats:sub> (‘S’ pathway) proteins.</jats:p></jats:list-item> <jats:list-item><jats:p>Herein, we discuss <jats:styled-content style="fixed-case">AIH</jats:styled-content>‐induced respiratory <jats:styled-content style="fixed-case">LTF</jats:styled-content> in animals and humans, as well as recent advances in our understanding of the synaptic and intracellular pathways underlying this form of plasticity. We also discuss the potential to use intermittent hypoxia to induce functional recovery following cervical spinal injury.</jats:p></jats:list-item> </jats:list> </jats:p> Acute intermittent hypoxia induced neural plasticity in respiratory motor control Clinical and Experimental Pharmacology and Physiology |
| spellingShingle | Xing, Tao, Fong, Angelina Y, Bautista, Tara G, Pilowsky, Paul M, Clinical and Experimental Pharmacology and Physiology, Acute intermittent hypoxia induced neural plasticity in respiratory motor control, Physiology (medical), Pharmacology, Physiology |
| title | Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_full | Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_fullStr | Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_full_unstemmed | Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_short | Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_sort | acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| title_unstemmed | Acute intermittent hypoxia induced neural plasticity in respiratory motor control |
| topic | Physiology (medical), Pharmacology, Physiology |
| url | http://dx.doi.org/10.1111/1440-1681.12129 |