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Ion channels, long QT syndrome and arrhythmogenesis in ageing
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| Zeitschriftentitel: | Clinical and Experimental Pharmacology and Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Clinical and Experimental Pharmacology and Physiology, 44, 2017, S1, S. 38-45 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Jeevaratnam, Kamalan Chadda, Karan R Salvage, Samantha C Valli, Haseeb Ahmad, Shiraz Grace, Andrew A Huang, Christopher L‐H Jeevaratnam, Kamalan Chadda, Karan R Salvage, Samantha C Valli, Haseeb Ahmad, Shiraz Grace, Andrew A Huang, Christopher L‐H |
|---|---|
| author |
Jeevaratnam, Kamalan Chadda, Karan R Salvage, Samantha C Valli, Haseeb Ahmad, Shiraz Grace, Andrew A Huang, Christopher L‐H |
| spellingShingle |
Jeevaratnam, Kamalan Chadda, Karan R Salvage, Samantha C Valli, Haseeb Ahmad, Shiraz Grace, Andrew A Huang, Christopher L‐H Clinical and Experimental Pharmacology and Physiology Ion channels, long QT syndrome and arrhythmogenesis in ageing Physiology (medical) Pharmacology Physiology |
| author_sort |
jeevaratnam, kamalan |
| spelling |
Jeevaratnam, Kamalan Chadda, Karan R Salvage, Samantha C Valli, Haseeb Ahmad, Shiraz Grace, Andrew A Huang, Christopher L‐H 0305-1870 1440-1681 Wiley Physiology (medical) Pharmacology Physiology http://dx.doi.org/10.1111/1440-1681.12721 <jats:title>Summary</jats:title><jats:p>Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify the interacting functional roles of ion channels and how their dysregulation contributes to arrhythmogenic processes at the cellular and systems level. They have also investigated interactions between these ion channel abnormalities and age‐related processes in producing arrhythmic tendency. Previous reviews have explored the relationships between age and loss‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations in producing arrhythmogenicity. The present review now explores complementary relationships arising from gain‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations associated with long <jats:styled-content style="fixed-case">QT</jats:styled-content>3 (<jats:styled-content style="fixed-case">LQTS</jats:styled-content>3). <jats:styled-content style="fixed-case">LQTS</jats:styled-content>3 patients show increased risks of life‐threatening ventricular arrhythmias, particularly after 40 years of age, consistent with such interactions between the ion channel abnormailities and ageing. In turn clinical evidence suggests that ageing is accompanied by structural, particularly fibrotic, as well as electrophysiological change. These abnormalities may result from biochemical changes producing low‐grade inflammation resulting from increased production of reactive oxygen species and superoxide. Experimental studies offer further insights into the underlying mechanisms underlying these phenotypes. Thus, studies in genetically modified murine models for <jats:styled-content style="fixed-case">LQTS</jats:styled-content> implicated action potential recovery processes in arrhythmogenesis resulting from functional ion channel abnormalities. In addition, ageing wild type (<jats:styled-content style="fixed-case">WT</jats:styled-content>) murine models demonstrated both ion channel alterations and fibrotic changes with ageing. Murine models then suggested evidence for interactions between ageing and ion channel mutations and provided insights into potential arrhythmic mechanisms inviting future exploration.</jats:p> Ion channels, long <scp>QT</scp> syndrome and arrhythmogenesis in ageing Clinical and Experimental Pharmacology and Physiology |
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Clinical and Experimental Pharmacology and Physiology |
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| title |
Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_unstemmed |
Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_full |
Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_fullStr |
Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_full_unstemmed |
Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_short |
Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_sort |
ion channels, long <scp>qt</scp> syndrome and arrhythmogenesis in ageing |
| topic |
Physiology (medical) Pharmacology Physiology |
| url |
http://dx.doi.org/10.1111/1440-1681.12721 |
| publishDate |
2017 |
| physical |
38-45 |
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<jats:title>Summary</jats:title><jats:p>Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify the interacting functional roles of ion channels and how their dysregulation contributes to arrhythmogenic processes at the cellular and systems level. They have also investigated interactions between these ion channel abnormalities and age‐related processes in producing arrhythmic tendency. Previous reviews have explored the relationships between age and loss‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations in producing arrhythmogenicity. The present review now explores complementary relationships arising from gain‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations associated with long <jats:styled-content style="fixed-case">QT</jats:styled-content>3 (<jats:styled-content style="fixed-case">LQTS</jats:styled-content>3). <jats:styled-content style="fixed-case">LQTS</jats:styled-content>3 patients show increased risks of life‐threatening ventricular arrhythmias, particularly after 40 years of age, consistent with such interactions between the ion channel abnormailities and ageing. In turn clinical evidence suggests that ageing is accompanied by structural, particularly fibrotic, as well as electrophysiological change. These abnormalities may result from biochemical changes producing low‐grade inflammation resulting from increased production of reactive oxygen species and superoxide. Experimental studies offer further insights into the underlying mechanisms underlying these phenotypes. Thus, studies in genetically modified murine models for <jats:styled-content style="fixed-case">LQTS</jats:styled-content> implicated action potential recovery processes in arrhythmogenesis resulting from functional ion channel abnormalities. In addition, ageing wild type (<jats:styled-content style="fixed-case">WT</jats:styled-content>) murine models demonstrated both ion channel alterations and fibrotic changes with ageing. Murine models then suggested evidence for interactions between ageing and ion channel mutations and provided insights into potential arrhythmic mechanisms inviting future exploration.</jats:p> |
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| author | Jeevaratnam, Kamalan, Chadda, Karan R, Salvage, Samantha C, Valli, Haseeb, Ahmad, Shiraz, Grace, Andrew A, Huang, Christopher L‐H |
| author_facet | Jeevaratnam, Kamalan, Chadda, Karan R, Salvage, Samantha C, Valli, Haseeb, Ahmad, Shiraz, Grace, Andrew A, Huang, Christopher L‐H, Jeevaratnam, Kamalan, Chadda, Karan R, Salvage, Samantha C, Valli, Haseeb, Ahmad, Shiraz, Grace, Andrew A, Huang, Christopher L‐H |
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| description | <jats:title>Summary</jats:title><jats:p>Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify the interacting functional roles of ion channels and how their dysregulation contributes to arrhythmogenic processes at the cellular and systems level. They have also investigated interactions between these ion channel abnormalities and age‐related processes in producing arrhythmic tendency. Previous reviews have explored the relationships between age and loss‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations in producing arrhythmogenicity. The present review now explores complementary relationships arising from gain‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations associated with long <jats:styled-content style="fixed-case">QT</jats:styled-content>3 (<jats:styled-content style="fixed-case">LQTS</jats:styled-content>3). <jats:styled-content style="fixed-case">LQTS</jats:styled-content>3 patients show increased risks of life‐threatening ventricular arrhythmias, particularly after 40 years of age, consistent with such interactions between the ion channel abnormailities and ageing. In turn clinical evidence suggests that ageing is accompanied by structural, particularly fibrotic, as well as electrophysiological change. These abnormalities may result from biochemical changes producing low‐grade inflammation resulting from increased production of reactive oxygen species and superoxide. Experimental studies offer further insights into the underlying mechanisms underlying these phenotypes. Thus, studies in genetically modified murine models for <jats:styled-content style="fixed-case">LQTS</jats:styled-content> implicated action potential recovery processes in arrhythmogenesis resulting from functional ion channel abnormalities. In addition, ageing wild type (<jats:styled-content style="fixed-case">WT</jats:styled-content>) murine models demonstrated both ion channel alterations and fibrotic changes with ageing. Murine models then suggested evidence for interactions between ageing and ion channel mutations and provided insights into potential arrhythmic mechanisms inviting future exploration.</jats:p> |
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| spelling | Jeevaratnam, Kamalan Chadda, Karan R Salvage, Samantha C Valli, Haseeb Ahmad, Shiraz Grace, Andrew A Huang, Christopher L‐H 0305-1870 1440-1681 Wiley Physiology (medical) Pharmacology Physiology http://dx.doi.org/10.1111/1440-1681.12721 <jats:title>Summary</jats:title><jats:p>Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify the interacting functional roles of ion channels and how their dysregulation contributes to arrhythmogenic processes at the cellular and systems level. They have also investigated interactions between these ion channel abnormalities and age‐related processes in producing arrhythmic tendency. Previous reviews have explored the relationships between age and loss‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations in producing arrhythmogenicity. The present review now explores complementary relationships arising from gain‐of‐function Na<jats:sub>v</jats:sub>1.5 mutations associated with long <jats:styled-content style="fixed-case">QT</jats:styled-content>3 (<jats:styled-content style="fixed-case">LQTS</jats:styled-content>3). <jats:styled-content style="fixed-case">LQTS</jats:styled-content>3 patients show increased risks of life‐threatening ventricular arrhythmias, particularly after 40 years of age, consistent with such interactions between the ion channel abnormailities and ageing. In turn clinical evidence suggests that ageing is accompanied by structural, particularly fibrotic, as well as electrophysiological change. These abnormalities may result from biochemical changes producing low‐grade inflammation resulting from increased production of reactive oxygen species and superoxide. Experimental studies offer further insights into the underlying mechanisms underlying these phenotypes. Thus, studies in genetically modified murine models for <jats:styled-content style="fixed-case">LQTS</jats:styled-content> implicated action potential recovery processes in arrhythmogenesis resulting from functional ion channel abnormalities. In addition, ageing wild type (<jats:styled-content style="fixed-case">WT</jats:styled-content>) murine models demonstrated both ion channel alterations and fibrotic changes with ageing. Murine models then suggested evidence for interactions between ageing and ion channel mutations and provided insights into potential arrhythmic mechanisms inviting future exploration.</jats:p> Ion channels, long <scp>QT</scp> syndrome and arrhythmogenesis in ageing Clinical and Experimental Pharmacology and Physiology |
| spellingShingle | Jeevaratnam, Kamalan, Chadda, Karan R, Salvage, Samantha C, Valli, Haseeb, Ahmad, Shiraz, Grace, Andrew A, Huang, Christopher L‐H, Clinical and Experimental Pharmacology and Physiology, Ion channels, long QT syndrome and arrhythmogenesis in ageing, Physiology (medical), Pharmacology, Physiology |
| title | Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_full | Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_fullStr | Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_full_unstemmed | Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_short | Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| title_sort | ion channels, long <scp>qt</scp> syndrome and arrhythmogenesis in ageing |
| title_unstemmed | Ion channels, long QT syndrome and arrhythmogenesis in ageing |
| topic | Physiology (medical), Pharmacology, Physiology |
| url | http://dx.doi.org/10.1111/1440-1681.12721 |