Eintrag weiter verarbeiten
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Gespeichert in:
| Zeitschriftentitel: | Learning & Memory |
|---|---|
| Personen und Körperschaften: | |
| In: | Learning & Memory, 10, 2003, 2, S. 86-98 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
|
| Schlagwörter: |
| author_facet |
Lu, Bai Lu, Bai |
|---|---|
| author |
Lu, Bai |
| spellingShingle |
Lu, Bai Learning & Memory BDNF and Activity-Dependent Synaptic Modulation: Figure 1. Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology |
| author_sort |
lu, bai |
| spelling |
Lu, Bai 1072-0502 1549-5485 Cold Spring Harbor Laboratory Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology http://dx.doi.org/10.1101/lm.54603 <jats:p>It is widely accepted that neuronal activity plays a pivotal role in synaptic plasticity. Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship between the activity and neurotrophic regulation of synapse development and plasticity, however, remains unclear. A prevailing hypothesis is that activity-dependent synaptic modulation is mediated by neurotrophins. An important but unresolved issue is how diffusible molecules such as neurotrophins achieve local and synapse-specific modulation. In this review, I discuss several potential mechanisms with which neuronal activity could control the synapse-specificity of neurotrophin regulation, with particular emphasis on BDNF. Data accumulated in recent years suggest that neuronal activity regulates the transcription of BDNF gene, the transport of BDNF mRNA and protein into dendrites, and the secretion of BDNF protein. There is also evidence for activity-dependent regulation of the trafficking of the BDNF receptor, TrkB, including its cell surface expression and ligand-induced endocytosis. Further study of these mechanisms will help us better understand how neurotrophins could mediate activity-dependent plasticity in a local and synapse-specific manner.</jats:p> BDNF and Activity-Dependent Synaptic Modulation: Figure 1. Learning & Memory |
| doi_str_mv |
10.1101/lm.54603 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Psychologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEwMS9sbS41NDYwMw |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEwMS9sbS41NDYwMw |
| institution |
DE-14 DE-105 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
Cold Spring Harbor Laboratory, 2003 |
| imprint_str_mv |
Cold Spring Harbor Laboratory, 2003 |
| issn |
1072-0502 1549-5485 |
| issn_str_mv |
1072-0502 1549-5485 |
| language |
English |
| mega_collection |
Cold Spring Harbor Laboratory (CrossRef) |
| match_str |
lu2003bdnfandactivitydependentsynapticmodulationfigure1 |
| publishDateSort |
2003 |
| publisher |
Cold Spring Harbor Laboratory |
| recordtype |
ai |
| record_format |
ai |
| series |
Learning & Memory |
| source_id |
49 |
| title |
BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_unstemmed |
BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_full |
BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_fullStr |
BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_full_unstemmed |
BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_short |
BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_sort |
bdnf and activity-dependent synaptic modulation: figure 1. |
| topic |
Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology |
| url |
http://dx.doi.org/10.1101/lm.54603 |
| publishDate |
2003 |
| physical |
86-98 |
| description |
<jats:p>It is widely accepted that neuronal activity plays a pivotal role in synaptic plasticity. Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship between the activity and neurotrophic regulation of synapse development and plasticity, however, remains unclear. A prevailing hypothesis is that activity-dependent synaptic modulation is mediated by neurotrophins. An important but unresolved issue is how diffusible molecules such as neurotrophins achieve local and synapse-specific modulation. In this review, I discuss several potential mechanisms with which neuronal activity could control the synapse-specificity of neurotrophin regulation, with particular emphasis on BDNF. Data accumulated in recent years suggest that neuronal activity regulates the transcription of BDNF gene, the transport of BDNF mRNA and protein into dendrites, and the secretion of BDNF protein. There is also evidence for activity-dependent regulation of the trafficking of the BDNF receptor, TrkB, including its cell surface expression and ligand-induced endocytosis. Further study of these mechanisms will help us better understand how neurotrophins could mediate activity-dependent plasticity in a local and synapse-specific manner.</jats:p> |
| container_issue |
2 |
| container_start_page |
86 |
| container_title |
Learning & Memory |
| container_volume |
10 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344970870390784 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:16:04.067Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=BDNF+and+Activity-Dependent+Synaptic+Modulation%3A+Figure+1.&rft.date=2003-03-01&genre=article&issn=1549-5485&volume=10&issue=2&spage=86&epage=98&pages=86-98&jtitle=Learning+%26+Memory&atitle=BDNF+and+Activity-Dependent+Synaptic+Modulation%3A+Figure+1.&aulast=Lu&aufirst=Bai&rft_id=info%3Adoi%2F10.1101%2Flm.54603&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344970870390784 |
| author | Lu, Bai |
| author_facet | Lu, Bai, Lu, Bai |
| author_sort | lu, bai |
| container_issue | 2 |
| container_start_page | 86 |
| container_title | Learning & Memory |
| container_volume | 10 |
| description | <jats:p>It is widely accepted that neuronal activity plays a pivotal role in synaptic plasticity. Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship between the activity and neurotrophic regulation of synapse development and plasticity, however, remains unclear. A prevailing hypothesis is that activity-dependent synaptic modulation is mediated by neurotrophins. An important but unresolved issue is how diffusible molecules such as neurotrophins achieve local and synapse-specific modulation. In this review, I discuss several potential mechanisms with which neuronal activity could control the synapse-specificity of neurotrophin regulation, with particular emphasis on BDNF. Data accumulated in recent years suggest that neuronal activity regulates the transcription of BDNF gene, the transport of BDNF mRNA and protein into dendrites, and the secretion of BDNF protein. There is also evidence for activity-dependent regulation of the trafficking of the BDNF receptor, TrkB, including its cell surface expression and ligand-induced endocytosis. Further study of these mechanisms will help us better understand how neurotrophins could mediate activity-dependent plasticity in a local and synapse-specific manner.</jats:p> |
| doi_str_mv | 10.1101/lm.54603 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Psychologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEwMS9sbS41NDYwMw |
| imprint | Cold Spring Harbor Laboratory, 2003 |
| imprint_str_mv | Cold Spring Harbor Laboratory, 2003 |
| institution | DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1 |
| issn | 1072-0502, 1549-5485 |
| issn_str_mv | 1072-0502, 1549-5485 |
| language | English |
| last_indexed | 2024-03-01T17:16:04.067Z |
| match_str | lu2003bdnfandactivitydependentsynapticmodulationfigure1 |
| mega_collection | Cold Spring Harbor Laboratory (CrossRef) |
| physical | 86-98 |
| publishDate | 2003 |
| publishDateSort | 2003 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | ai |
| recordtype | ai |
| series | Learning & Memory |
| source_id | 49 |
| spelling | Lu, Bai 1072-0502 1549-5485 Cold Spring Harbor Laboratory Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology http://dx.doi.org/10.1101/lm.54603 <jats:p>It is widely accepted that neuronal activity plays a pivotal role in synaptic plasticity. Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship between the activity and neurotrophic regulation of synapse development and plasticity, however, remains unclear. A prevailing hypothesis is that activity-dependent synaptic modulation is mediated by neurotrophins. An important but unresolved issue is how diffusible molecules such as neurotrophins achieve local and synapse-specific modulation. In this review, I discuss several potential mechanisms with which neuronal activity could control the synapse-specificity of neurotrophin regulation, with particular emphasis on BDNF. Data accumulated in recent years suggest that neuronal activity regulates the transcription of BDNF gene, the transport of BDNF mRNA and protein into dendrites, and the secretion of BDNF protein. There is also evidence for activity-dependent regulation of the trafficking of the BDNF receptor, TrkB, including its cell surface expression and ligand-induced endocytosis. Further study of these mechanisms will help us better understand how neurotrophins could mediate activity-dependent plasticity in a local and synapse-specific manner.</jats:p> BDNF and Activity-Dependent Synaptic Modulation: Figure 1. Learning & Memory |
| spellingShingle | Lu, Bai, Learning & Memory, BDNF and Activity-Dependent Synaptic Modulation: Figure 1., Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neuropsychology and Physiological Psychology |
| title | BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_full | BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_fullStr | BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_full_unstemmed | BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_short | BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| title_sort | bdnf and activity-dependent synaptic modulation: figure 1. |
| title_unstemmed | BDNF and Activity-Dependent Synaptic Modulation: Figure 1. |
| topic | Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neuropsychology and Physiological Psychology |
| url | http://dx.doi.org/10.1101/lm.54603 |