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miR than meets the eye: Figure 1.
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| Zeitschriftentitel: | Genes & Development |
|---|---|
| Personen und Körperschaften: | , |
| In: | Genes & Development, 25, 2011, 16, S. 1663-1667 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
|
| Schlagwörter: |
| author_facet |
Sage, Julien Ventura, Andrea Sage, Julien Ventura, Andrea |
|---|---|
| author |
Sage, Julien Ventura, Andrea |
| spellingShingle |
Sage, Julien Ventura, Andrea Genes & Development miR than meets the eye: Figure 1. Developmental Biology Genetics |
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sage, julien |
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Sage, Julien Ventura, Andrea 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.17454011 <jats:p>Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigenesis. In this issue of <jats:italic>Genes & Development</jats:italic>, Conkrite and colleagues (pp. 1734–1745) found high levels of the <jats:italic>miR-17∼92</jats:italic> and <jats:italic>miR-106b-25</jats:italic> microRNAs in primary retinoblastomas and show that overexpression of <jats:italic>miR-17∼92</jats:italic> accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the <jats:italic>RB/miR-17∼92/p21</jats:italic> axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers.</jats:p> miR than meets the eye: Figure 1. Genes & Development |
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| title |
miR than meets the eye: Figure 1. |
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miR than meets the eye: Figure 1. |
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miR than meets the eye: Figure 1. |
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miR than meets the eye: Figure 1. |
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miR than meets the eye: Figure 1. |
| title_short |
miR than meets the eye: Figure 1. |
| title_sort |
mir than meets the eye: figure 1. |
| topic |
Developmental Biology Genetics |
| url |
http://dx.doi.org/10.1101/gad.17454011 |
| publishDate |
2011 |
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1663-1667 |
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<jats:p>Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigenesis. In this issue of <jats:italic>Genes & Development</jats:italic>, Conkrite and colleagues (pp. 1734–1745) found high levels of the <jats:italic>miR-17∼92</jats:italic> and <jats:italic>miR-106b-25</jats:italic> microRNAs in primary retinoblastomas and show that overexpression of <jats:italic>miR-17∼92</jats:italic> accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the <jats:italic>RB/miR-17∼92/p21</jats:italic> axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers.</jats:p> |
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| description | <jats:p>Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigenesis. In this issue of <jats:italic>Genes & Development</jats:italic>, Conkrite and colleagues (pp. 1734–1745) found high levels of the <jats:italic>miR-17∼92</jats:italic> and <jats:italic>miR-106b-25</jats:italic> microRNAs in primary retinoblastomas and show that overexpression of <jats:italic>miR-17∼92</jats:italic> accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the <jats:italic>RB/miR-17∼92/p21</jats:italic> axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers.</jats:p> |
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| spelling | Sage, Julien Ventura, Andrea 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.17454011 <jats:p>Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigenesis. In this issue of <jats:italic>Genes & Development</jats:italic>, Conkrite and colleagues (pp. 1734–1745) found high levels of the <jats:italic>miR-17∼92</jats:italic> and <jats:italic>miR-106b-25</jats:italic> microRNAs in primary retinoblastomas and show that overexpression of <jats:italic>miR-17∼92</jats:italic> accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the <jats:italic>RB/miR-17∼92/p21</jats:italic> axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers.</jats:p> miR than meets the eye: Figure 1. Genes & Development |
| spellingShingle | Sage, Julien, Ventura, Andrea, Genes & Development, miR than meets the eye: Figure 1., Developmental Biology, Genetics |
| title | miR than meets the eye: Figure 1. |
| title_full | miR than meets the eye: Figure 1. |
| title_fullStr | miR than meets the eye: Figure 1. |
| title_full_unstemmed | miR than meets the eye: Figure 1. |
| title_short | miR than meets the eye: Figure 1. |
| title_sort | mir than meets the eye: figure 1. |
| title_unstemmed | miR than meets the eye: Figure 1. |
| topic | Developmental Biology, Genetics |
| url | http://dx.doi.org/10.1101/gad.17454011 |