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Identification of cis-acting sites for condensin loading onto budding yeast chromosomes
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| Zeitschriftentitel: | Genes & Development |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Genes & Development, 22, 2008, 16, S. 2215-2227 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
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| Schlagwörter: |
| author_facet |
D’Ambrosio, Claudio Schmidt, Christine Katrin Katou, Yuki Kelly, Gavin Itoh, Takehiko Shirahige, Katsuhiko Uhlmann, Frank D’Ambrosio, Claudio Schmidt, Christine Katrin Katou, Yuki Kelly, Gavin Itoh, Takehiko Shirahige, Katsuhiko Uhlmann, Frank |
|---|---|
| author |
D’Ambrosio, Claudio Schmidt, Christine Katrin Katou, Yuki Kelly, Gavin Itoh, Takehiko Shirahige, Katsuhiko Uhlmann, Frank |
| spellingShingle |
D’Ambrosio, Claudio Schmidt, Christine Katrin Katou, Yuki Kelly, Gavin Itoh, Takehiko Shirahige, Katsuhiko Uhlmann, Frank Genes & Development Identification of cis-acting sites for condensin loading onto budding yeast chromosomes Developmental Biology Genetics |
| author_sort |
d’ambrosio, claudio |
| spelling |
D’Ambrosio, Claudio Schmidt, Christine Katrin Katou, Yuki Kelly, Gavin Itoh, Takehiko Shirahige, Katsuhiko Uhlmann, Frank 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1675708 <jats:p>Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonucleotide tiling arrays. Condensin-binding sites coincide with those of the loading factor Scc2/4 of the related cohesin complex. The sites map to tRNA and other genes bound by the RNA polymerase III transcription factor TFIIIC, and ribosomal protein and <jats:italic>SNR</jats:italic> genes. An ectopic B-box element, recognized by TFIIIC, constitutes a minimal condensin-binding site, and TFIIIC and the Scc2/4 complex promote functional condensin association with chromosomes. A similar pattern of condensin binding is conserved along fission yeast chromosomes. This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis.</jats:p> Identification of <i>cis</i>-acting sites for condensin loading onto budding yeast chromosomes Genes & Development |
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| title |
Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_unstemmed |
Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_full |
Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_fullStr |
Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_full_unstemmed |
Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_short |
Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_sort |
identification of <i>cis</i>-acting sites for condensin loading onto budding yeast chromosomes |
| topic |
Developmental Biology Genetics |
| url |
http://dx.doi.org/10.1101/gad.1675708 |
| publishDate |
2008 |
| physical |
2215-2227 |
| description |
<jats:p>Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonucleotide tiling arrays. Condensin-binding sites coincide with those of the loading factor Scc2/4 of the related cohesin complex. The sites map to tRNA and other genes bound by the RNA polymerase III transcription factor TFIIIC, and ribosomal protein and <jats:italic>SNR</jats:italic> genes. An ectopic B-box element, recognized by TFIIIC, constitutes a minimal condensin-binding site, and TFIIIC and the Scc2/4 complex promote functional condensin association with chromosomes. A similar pattern of condensin binding is conserved along fission yeast chromosomes. This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis.</jats:p> |
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| author | D’Ambrosio, Claudio, Schmidt, Christine Katrin, Katou, Yuki, Kelly, Gavin, Itoh, Takehiko, Shirahige, Katsuhiko, Uhlmann, Frank |
| author_facet | D’Ambrosio, Claudio, Schmidt, Christine Katrin, Katou, Yuki, Kelly, Gavin, Itoh, Takehiko, Shirahige, Katsuhiko, Uhlmann, Frank, D’Ambrosio, Claudio, Schmidt, Christine Katrin, Katou, Yuki, Kelly, Gavin, Itoh, Takehiko, Shirahige, Katsuhiko, Uhlmann, Frank |
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| description | <jats:p>Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonucleotide tiling arrays. Condensin-binding sites coincide with those of the loading factor Scc2/4 of the related cohesin complex. The sites map to tRNA and other genes bound by the RNA polymerase III transcription factor TFIIIC, and ribosomal protein and <jats:italic>SNR</jats:italic> genes. An ectopic B-box element, recognized by TFIIIC, constitutes a minimal condensin-binding site, and TFIIIC and the Scc2/4 complex promote functional condensin association with chromosomes. A similar pattern of condensin binding is conserved along fission yeast chromosomes. This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis.</jats:p> |
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| imprint | Cold Spring Harbor Laboratory, 2008 |
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| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
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| spelling | D’Ambrosio, Claudio Schmidt, Christine Katrin Katou, Yuki Kelly, Gavin Itoh, Takehiko Shirahige, Katsuhiko Uhlmann, Frank 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1675708 <jats:p>Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonucleotide tiling arrays. Condensin-binding sites coincide with those of the loading factor Scc2/4 of the related cohesin complex. The sites map to tRNA and other genes bound by the RNA polymerase III transcription factor TFIIIC, and ribosomal protein and <jats:italic>SNR</jats:italic> genes. An ectopic B-box element, recognized by TFIIIC, constitutes a minimal condensin-binding site, and TFIIIC and the Scc2/4 complex promote functional condensin association with chromosomes. A similar pattern of condensin binding is conserved along fission yeast chromosomes. This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis.</jats:p> Identification of <i>cis</i>-acting sites for condensin loading onto budding yeast chromosomes Genes & Development |
| spellingShingle | D’Ambrosio, Claudio, Schmidt, Christine Katrin, Katou, Yuki, Kelly, Gavin, Itoh, Takehiko, Shirahige, Katsuhiko, Uhlmann, Frank, Genes & Development, Identification of cis-acting sites for condensin loading onto budding yeast chromosomes, Developmental Biology, Genetics |
| title | Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_full | Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_fullStr | Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_full_unstemmed | Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_short | Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| title_sort | identification of <i>cis</i>-acting sites for condensin loading onto budding yeast chromosomes |
| title_unstemmed | Identification of cis-acting sites for condensin loading onto budding yeast chromosomes |
| topic | Developmental Biology, Genetics |
| url | http://dx.doi.org/10.1101/gad.1675708 |