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Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos
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| Zeitschriftentitel: | Genes & Development |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Genes & Development, 19, 2005, 15, S. 1749-1754 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
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| Schlagwörter: |
| author_facet |
Nakamura, Kuniaki Kim, Soyoung Ishidate, Takao Bei, Yanxia Pang, Kaming Shirayama, Masaki Trzepacz, Chris Brownell, Daniel R. Mello, Craig C. Nakamura, Kuniaki Kim, Soyoung Ishidate, Takao Bei, Yanxia Pang, Kaming Shirayama, Masaki Trzepacz, Chris Brownell, Daniel R. Mello, Craig C. |
|---|---|
| author |
Nakamura, Kuniaki Kim, Soyoung Ishidate, Takao Bei, Yanxia Pang, Kaming Shirayama, Masaki Trzepacz, Chris Brownell, Daniel R. Mello, Craig C. |
| spellingShingle |
Nakamura, Kuniaki Kim, Soyoung Ishidate, Takao Bei, Yanxia Pang, Kaming Shirayama, Masaki Trzepacz, Chris Brownell, Daniel R. Mello, Craig C. Genes & Development Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos Developmental Biology Genetics |
| author_sort |
nakamura, kuniaki |
| spelling |
Nakamura, Kuniaki Kim, Soyoung Ishidate, Takao Bei, Yanxia Pang, Kaming Shirayama, Masaki Trzepacz, Chris Brownell, Daniel R. Mello, Craig C. 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1323705 <jats:p>β-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of β-catenin contributes to numerous forms of cancer in humans. Here we describe <jats:italic>Caenorhabditis elegans</jats:italic> conditional alleles of <jats:italic>mom-2/Wnt</jats:italic>, <jats:italic>mom-4/Tak1</jats:italic>, and <jats:italic>wrm-1</jats:italic>/β-catenin. We use these reagents to examine the regulation of WRM-1/β-catenin during a Wnt-signaling-induced asymmetric cell division. While WRM-1 protein initially accumulates in the nuclei of all cells, signaling promotes the retention of WRM-1 in nuclei of responding cells. We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of β-catenin during polarized cell division.</jats:p> Wnt signaling drives WRM-1/β-catenin asymmetries in early <i>C. elegans</i> embryos Genes & Development |
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10.1101/gad.1323705 |
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Cold Spring Harbor Laboratory, 2005 |
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Cold Spring Harbor Laboratory, 2005 |
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| title |
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_unstemmed |
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_full |
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_fullStr |
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_full_unstemmed |
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_short |
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_sort |
wnt signaling drives wrm-1/β-catenin asymmetries in early <i>c. elegans</i> embryos |
| topic |
Developmental Biology Genetics |
| url |
http://dx.doi.org/10.1101/gad.1323705 |
| publishDate |
2005 |
| physical |
1749-1754 |
| description |
<jats:p>β-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of β-catenin contributes to numerous forms of cancer in humans. Here we describe <jats:italic>Caenorhabditis elegans</jats:italic> conditional alleles of <jats:italic>mom-2/Wnt</jats:italic>, <jats:italic>mom-4/Tak1</jats:italic>, and <jats:italic>wrm-1</jats:italic>/β-catenin. We use these reagents to examine the regulation of WRM-1/β-catenin during a Wnt-signaling-induced asymmetric cell division. While WRM-1 protein initially accumulates in the nuclei of all cells, signaling promotes the retention of WRM-1 in nuclei of responding cells. We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of β-catenin during polarized cell division.</jats:p> |
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| author | Nakamura, Kuniaki, Kim, Soyoung, Ishidate, Takao, Bei, Yanxia, Pang, Kaming, Shirayama, Masaki, Trzepacz, Chris, Brownell, Daniel R., Mello, Craig C. |
| author_facet | Nakamura, Kuniaki, Kim, Soyoung, Ishidate, Takao, Bei, Yanxia, Pang, Kaming, Shirayama, Masaki, Trzepacz, Chris, Brownell, Daniel R., Mello, Craig C., Nakamura, Kuniaki, Kim, Soyoung, Ishidate, Takao, Bei, Yanxia, Pang, Kaming, Shirayama, Masaki, Trzepacz, Chris, Brownell, Daniel R., Mello, Craig C. |
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| description | <jats:p>β-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of β-catenin contributes to numerous forms of cancer in humans. Here we describe <jats:italic>Caenorhabditis elegans</jats:italic> conditional alleles of <jats:italic>mom-2/Wnt</jats:italic>, <jats:italic>mom-4/Tak1</jats:italic>, and <jats:italic>wrm-1</jats:italic>/β-catenin. We use these reagents to examine the regulation of WRM-1/β-catenin during a Wnt-signaling-induced asymmetric cell division. While WRM-1 protein initially accumulates in the nuclei of all cells, signaling promotes the retention of WRM-1 in nuclei of responding cells. We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of β-catenin during polarized cell division.</jats:p> |
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| imprint | Cold Spring Harbor Laboratory, 2005 |
| imprint_str_mv | Cold Spring Harbor Laboratory, 2005 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| spelling | Nakamura, Kuniaki Kim, Soyoung Ishidate, Takao Bei, Yanxia Pang, Kaming Shirayama, Masaki Trzepacz, Chris Brownell, Daniel R. Mello, Craig C. 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1323705 <jats:p>β-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of β-catenin contributes to numerous forms of cancer in humans. Here we describe <jats:italic>Caenorhabditis elegans</jats:italic> conditional alleles of <jats:italic>mom-2/Wnt</jats:italic>, <jats:italic>mom-4/Tak1</jats:italic>, and <jats:italic>wrm-1</jats:italic>/β-catenin. We use these reagents to examine the regulation of WRM-1/β-catenin during a Wnt-signaling-induced asymmetric cell division. While WRM-1 protein initially accumulates in the nuclei of all cells, signaling promotes the retention of WRM-1 in nuclei of responding cells. We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of β-catenin during polarized cell division.</jats:p> Wnt signaling drives WRM-1/β-catenin asymmetries in early <i>C. elegans</i> embryos Genes & Development |
| spellingShingle | Nakamura, Kuniaki, Kim, Soyoung, Ishidate, Takao, Bei, Yanxia, Pang, Kaming, Shirayama, Masaki, Trzepacz, Chris, Brownell, Daniel R., Mello, Craig C., Genes & Development, Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos, Developmental Biology, Genetics |
| title | Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_full | Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_fullStr | Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_full_unstemmed | Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_short | Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| title_sort | wnt signaling drives wrm-1/β-catenin asymmetries in early <i>c. elegans</i> embryos |
| title_unstemmed | Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos |
| topic | Developmental Biology, Genetics |
| url | http://dx.doi.org/10.1101/gad.1323705 |