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Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days
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| Zeitschriftentitel: | Annals of the New York Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Annals of the New York Academy of Sciences, 1031, 2004, 1, S. 184-194 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
EKANAYAKE‐MUDIYANSELAGE, SWARNA KRAEMER, KLAUS THIELE, JENS J. EKANAYAKE‐MUDIYANSELAGE, SWARNA KRAEMER, KLAUS THIELE, JENS J. |
|---|---|
| author |
EKANAYAKE‐MUDIYANSELAGE, SWARNA KRAEMER, KLAUS THIELE, JENS J. |
| spellingShingle |
EKANAYAKE‐MUDIYANSELAGE, SWARNA KRAEMER, KLAUS THIELE, JENS J. Annals of the New York Academy of Sciences Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
| author_sort |
ekanayake‐mudiyanselage, swarna |
| spelling |
EKANAYAKE‐MUDIYANSELAGE, SWARNA KRAEMER, KLAUS THIELE, JENS J. 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1196/annals.1331.017 <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> In human skin, highest α‐tocopherol levels are found in facial sebum. We hypothesized that the bioavailability of vitamin E in human skin is, at least in part, dependent on sebaceous gland secretion. To test this, 24 volunteers were subjected to a randomized daily supplementation with either 400 mg <jats:italic>RRR</jats:italic>‐α‐tocopheryl acetate (<jats:italic>RRR</jats:italic>‐α‐toc) or 400 mg <jats:italic>all‐rac</jats:italic>‐α‐tocopheryl acetate (<jats:italic>all‐rac</jats:italic>‐α‐toc) for 14 days. Fasting blood samples, facial sebum samples, and lower‐arm skin‐surface lipids (SSL) were taken at time‐points between 0‐21 days. Samples were analyzed by HPLC for α‐tocopherol and squalene concentrations. Increased serum α‐tocopherol levels were detectable as early as 12 h after supplementation of <jats:italic>RRR</jats:italic>‐α‐toc or <jats:italic>all‐rac</jats:italic>‐α‐toc and peaked on day 7. No significant changes were observed in lower‐arm SSL. Remarkably, while unchanged until day 14, α‐tocopherol sebum levels were increased on day 21 in both the <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc group by 87% and 92%, respectively. With respect to dietary supplementation of vitamin E and its bioavailability in human skin, these results suggest that (1) sebaceous gland secretion is a relevant delivery mechanism; (2) the bioavailabilities of <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc are similar; and (3) significant accumulation requires a daily supplementation period of at least 2‐3 weeks.</jats:p> Oral Supplementation with <i>All‐Rac</i>‐ and <i>RRR</i>‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days Annals of the New York Academy of Sciences |
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| title |
Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_unstemmed |
Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_full |
Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_fullStr |
Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_full_unstemmed |
Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_short |
Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_sort |
oral supplementation with <i>all‐rac</i>‐ and <i>rrr</i>‐α‐tocopherol increases vitamin e levels in human sebum after a latency period of 14‐21 days |
| topic |
History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience |
| url |
http://dx.doi.org/10.1196/annals.1331.017 |
| publishDate |
2004 |
| physical |
184-194 |
| description |
<jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> In human skin, highest α‐tocopherol levels are found in facial sebum. We hypothesized that the bioavailability of vitamin E in human skin is, at least in part, dependent on sebaceous gland secretion. To test this, 24 volunteers were subjected to a randomized daily supplementation with either 400 mg <jats:italic>RRR</jats:italic>‐α‐tocopheryl acetate (<jats:italic>RRR</jats:italic>‐α‐toc) or 400 mg <jats:italic>all‐rac</jats:italic>‐α‐tocopheryl acetate (<jats:italic>all‐rac</jats:italic>‐α‐toc) for 14 days. Fasting blood samples, facial sebum samples, and lower‐arm skin‐surface lipids (SSL) were taken at time‐points between 0‐21 days. Samples were analyzed by HPLC for α‐tocopherol and squalene concentrations. Increased serum α‐tocopherol levels were detectable as early as 12 h after supplementation of <jats:italic>RRR</jats:italic>‐α‐toc or <jats:italic>all‐rac</jats:italic>‐α‐toc and peaked on day 7. No significant changes were observed in lower‐arm SSL. Remarkably, while unchanged until day 14, α‐tocopherol sebum levels were increased on day 21 in both the <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc group by 87% and 92%, respectively. With respect to dietary supplementation of vitamin E and its bioavailability in human skin, these results suggest that (1) sebaceous gland secretion is a relevant delivery mechanism; (2) the bioavailabilities of <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc are similar; and (3) significant accumulation requires a daily supplementation period of at least 2‐3 weeks.</jats:p> |
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| description | <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> In human skin, highest α‐tocopherol levels are found in facial sebum. We hypothesized that the bioavailability of vitamin E in human skin is, at least in part, dependent on sebaceous gland secretion. To test this, 24 volunteers were subjected to a randomized daily supplementation with either 400 mg <jats:italic>RRR</jats:italic>‐α‐tocopheryl acetate (<jats:italic>RRR</jats:italic>‐α‐toc) or 400 mg <jats:italic>all‐rac</jats:italic>‐α‐tocopheryl acetate (<jats:italic>all‐rac</jats:italic>‐α‐toc) for 14 days. Fasting blood samples, facial sebum samples, and lower‐arm skin‐surface lipids (SSL) were taken at time‐points between 0‐21 days. Samples were analyzed by HPLC for α‐tocopherol and squalene concentrations. Increased serum α‐tocopherol levels were detectable as early as 12 h after supplementation of <jats:italic>RRR</jats:italic>‐α‐toc or <jats:italic>all‐rac</jats:italic>‐α‐toc and peaked on day 7. No significant changes were observed in lower‐arm SSL. Remarkably, while unchanged until day 14, α‐tocopherol sebum levels were increased on day 21 in both the <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc group by 87% and 92%, respectively. With respect to dietary supplementation of vitamin E and its bioavailability in human skin, these results suggest that (1) sebaceous gland secretion is a relevant delivery mechanism; (2) the bioavailabilities of <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc are similar; and (3) significant accumulation requires a daily supplementation period of at least 2‐3 weeks.</jats:p> |
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| spelling | EKANAYAKE‐MUDIYANSELAGE, SWARNA KRAEMER, KLAUS THIELE, JENS J. 0077-8923 1749-6632 Wiley History and Philosophy of Science General Biochemistry, Genetics and Molecular Biology General Neuroscience http://dx.doi.org/10.1196/annals.1331.017 <jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> In human skin, highest α‐tocopherol levels are found in facial sebum. We hypothesized that the bioavailability of vitamin E in human skin is, at least in part, dependent on sebaceous gland secretion. To test this, 24 volunteers were subjected to a randomized daily supplementation with either 400 mg <jats:italic>RRR</jats:italic>‐α‐tocopheryl acetate (<jats:italic>RRR</jats:italic>‐α‐toc) or 400 mg <jats:italic>all‐rac</jats:italic>‐α‐tocopheryl acetate (<jats:italic>all‐rac</jats:italic>‐α‐toc) for 14 days. Fasting blood samples, facial sebum samples, and lower‐arm skin‐surface lipids (SSL) were taken at time‐points between 0‐21 days. Samples were analyzed by HPLC for α‐tocopherol and squalene concentrations. Increased serum α‐tocopherol levels were detectable as early as 12 h after supplementation of <jats:italic>RRR</jats:italic>‐α‐toc or <jats:italic>all‐rac</jats:italic>‐α‐toc and peaked on day 7. No significant changes were observed in lower‐arm SSL. Remarkably, while unchanged until day 14, α‐tocopherol sebum levels were increased on day 21 in both the <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc group by 87% and 92%, respectively. With respect to dietary supplementation of vitamin E and its bioavailability in human skin, these results suggest that (1) sebaceous gland secretion is a relevant delivery mechanism; (2) the bioavailabilities of <jats:italic>RRR</jats:italic>‐α‐toc and the <jats:italic>all‐rac</jats:italic>‐α‐toc are similar; and (3) significant accumulation requires a daily supplementation period of at least 2‐3 weeks.</jats:p> Oral Supplementation with <i>All‐Rac</i>‐ and <i>RRR</i>‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days Annals of the New York Academy of Sciences |
| spellingShingle | EKANAYAKE‐MUDIYANSELAGE, SWARNA, KRAEMER, KLAUS, THIELE, JENS J., Annals of the New York Academy of Sciences, Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days, History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| title | Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_full | Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_fullStr | Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_full_unstemmed | Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_short | Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| title_sort | oral supplementation with <i>all‐rac</i>‐ and <i>rrr</i>‐α‐tocopherol increases vitamin e levels in human sebum after a latency period of 14‐21 days |
| title_unstemmed | Oral Supplementation with All‐Rac‐ and RRR‐α‐Tocopherol Increases Vitamin E Levels in Human Sebum after a Latency Period of 14‐21 Days |
| topic | History and Philosophy of Science, General Biochemistry, Genetics and Molecular Biology, General Neuroscience |
| url | http://dx.doi.org/10.1196/annals.1331.017 |