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Do antipsychotic drugs lose their efficacy for relapse prevention over time?
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| Zeitschriftentitel: | British Journal of Psychiatry |
|---|---|
| Personen und Körperschaften: | , |
| In: | British Journal of Psychiatry, 211, 2017, 3, S. 127-129 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Royal College of Psychiatrists
|
| Schlagwörter: |
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Leucht, Stefan Davis, John M. Leucht, Stefan Davis, John M. |
|---|---|
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Leucht, Stefan Davis, John M. |
| spellingShingle |
Leucht, Stefan Davis, John M. British Journal of Psychiatry Do antipsychotic drugs lose their efficacy for relapse prevention over time? Psychiatry and Mental health |
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leucht, stefan |
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Leucht, Stefan Davis, John M. 0007-1250 1472-1465 Royal College of Psychiatrists Psychiatry and Mental health http://dx.doi.org/10.1192/bjp.bp.117.201103 <jats:title>Summary</jats:title><jats:p>There is a debate about long-term treatment of schizophrenia with antipsychotic drugs, with some experts suggesting that these drugs should be discontinued. In this issue, Takeuchi <jats:italic>et al</jats:italic> demonstrated by a meta-analysis of 11 trials that antipsychotic drugs maintained their efficacy for relapse prevention for 1 year, whereas patients on placebo kept getting worse. We consider these findings in the light of the current discussion about possible dose-related brain volume loss, supersensitivity psychosis, the high variability of results in long-term follow-up studies and recent approaches to discontinue antipsychotics in patients with a first-episode. The new findings speak in favour of continuing antipsychotics at the same dose, at least in patients whose condition is chronic, but the topic is complex.</jats:p> Do antipsychotic drugs lose their efficacy for relapse prevention over time? British Journal of Psychiatry |
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| title |
Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| title_unstemmed |
Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
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Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
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Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
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Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
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Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
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do antipsychotic drugs lose their efficacy for relapse prevention over time? |
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Psychiatry and Mental health |
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http://dx.doi.org/10.1192/bjp.bp.117.201103 |
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2017 |
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127-129 |
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<jats:title>Summary</jats:title><jats:p>There is a debate about long-term treatment of schizophrenia with antipsychotic drugs, with some experts suggesting that these drugs should be discontinued. In this issue, Takeuchi <jats:italic>et al</jats:italic> demonstrated by a meta-analysis of 11 trials that antipsychotic drugs maintained their efficacy for relapse prevention for 1 year, whereas patients on placebo kept getting worse. We consider these findings in the light of the current discussion about possible dose-related brain volume loss, supersensitivity psychosis, the high variability of results in long-term follow-up studies and recent approaches to discontinue antipsychotics in patients with a first-episode. The new findings speak in favour of continuing antipsychotics at the same dose, at least in patients whose condition is chronic, but the topic is complex.</jats:p> |
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| description | <jats:title>Summary</jats:title><jats:p>There is a debate about long-term treatment of schizophrenia with antipsychotic drugs, with some experts suggesting that these drugs should be discontinued. In this issue, Takeuchi <jats:italic>et al</jats:italic> demonstrated by a meta-analysis of 11 trials that antipsychotic drugs maintained their efficacy for relapse prevention for 1 year, whereas patients on placebo kept getting worse. We consider these findings in the light of the current discussion about possible dose-related brain volume loss, supersensitivity psychosis, the high variability of results in long-term follow-up studies and recent approaches to discontinue antipsychotics in patients with a first-episode. The new findings speak in favour of continuing antipsychotics at the same dose, at least in patients whose condition is chronic, but the topic is complex.</jats:p> |
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| spelling | Leucht, Stefan Davis, John M. 0007-1250 1472-1465 Royal College of Psychiatrists Psychiatry and Mental health http://dx.doi.org/10.1192/bjp.bp.117.201103 <jats:title>Summary</jats:title><jats:p>There is a debate about long-term treatment of schizophrenia with antipsychotic drugs, with some experts suggesting that these drugs should be discontinued. In this issue, Takeuchi <jats:italic>et al</jats:italic> demonstrated by a meta-analysis of 11 trials that antipsychotic drugs maintained their efficacy for relapse prevention for 1 year, whereas patients on placebo kept getting worse. We consider these findings in the light of the current discussion about possible dose-related brain volume loss, supersensitivity psychosis, the high variability of results in long-term follow-up studies and recent approaches to discontinue antipsychotics in patients with a first-episode. The new findings speak in favour of continuing antipsychotics at the same dose, at least in patients whose condition is chronic, but the topic is complex.</jats:p> Do antipsychotic drugs lose their efficacy for relapse prevention over time? British Journal of Psychiatry |
| spellingShingle | Leucht, Stefan, Davis, John M., British Journal of Psychiatry, Do antipsychotic drugs lose their efficacy for relapse prevention over time?, Psychiatry and Mental health |
| title | Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| title_full | Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| title_fullStr | Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| title_full_unstemmed | Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| title_short | Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| title_sort | do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| title_unstemmed | Do antipsychotic drugs lose their efficacy for relapse prevention over time? |
| topic | Psychiatry and Mental health |
| url | http://dx.doi.org/10.1192/bjp.bp.117.201103 |