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Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease
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| Zeitschriftentitel: | European Respiratory Journal |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | European Respiratory Journal, 12, 1998, 2, S. 380-386 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
European Respiratory Society (ERS)
|
| Schlagwörter: |
| author_facet |
Pesci, A Balbi, B Majori, M Cacciani, G Bertacco, S Alciato, P Donner, CF Pesci, A Balbi, B Majori, M Cacciani, G Bertacco, S Alciato, P Donner, CF |
|---|---|
| author |
Pesci, A Balbi, B Majori, M Cacciani, G Bertacco, S Alciato, P Donner, CF |
| spellingShingle |
Pesci, A Balbi, B Majori, M Cacciani, G Bertacco, S Alciato, P Donner, CF European Respiratory Journal Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease Pulmonary and Respiratory Medicine |
| author_sort |
pesci, a |
| spelling |
Pesci, A Balbi, B Majori, M Cacciani, G Bertacco, S Alciato, P Donner, CF 0903-1936 1399-3003 European Respiratory Society (ERS) Pulmonary and Respiratory Medicine http://dx.doi.org/10.1183/09031936.98.12020380 <jats:p>Cigarette smoking is the most important cause of chronic obstructive pulmonary disease (COPD). Although the precise sequence of events that leads a smoker to experience airway obstruction is not completely clear, airway inflammation is a relevant factor. To investigate airway inflammation, 12 nonatopic smoking COPD patients with a forced expiratory volume in one second (FEV1) < or = 75% predicted and 10 normal nonsmoking subjects (NS) were studied with bronchoscopy and bronchial lavage (BL). Serum immunoglobulin (Ig)E levels of COPD patients correlated with the smoking history (r=0.7, p=0.008). In BL of COPD patients there was an increase of neutrophils (median, range) (COPD 62.6x10(3), 1.2-323, NS 1.35, 0-19.2, p=0.001), eosinophils (COPD 1.6, 0-6.9, NS 0.15, 0-3.7, p=0.035), the levels of interleukin (IL)-8 (COPD 1079 pg x mL(-1), 121-2,500, NS 20.4, 7.2-59, p=0.001), myeloperoxidase (MPO) (COPD 752 microg x L(-1), 11-5,500, NS 22.1, 8-70, p=0.001) and eosinophil cationic protein (ECP) (COPD 21.5 microg x L(-1), 1.8-161, NS 2, 1.8-4.9, p=0.001). Significant correlations were found in BL of COPD patients between IL-8 and neutrophils (p=0.02), MPO and neutrophils (p=0.02), IL-8 and MPO (p=0.0001) and ECP and eosinophils (p=0.02). In addition, the ratios between the BL levels of MPO and the number of neutrophils and between ECP levels and eosinophils were higher in COPD patients than in NS (p=0.03 and 0.01, respectively). These data suggest that cigarette smoke is associated with increased amounts of airway interleukin-8, a chemotactic factor for neutrophils and eosinophils. Recruited neutrophils and eosinophils are activated and they release increased amounts of inflammatory mediators capable of damaging the bronchial tissue.</jats:p> Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease European Respiratory Journal |
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| title |
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_unstemmed |
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_full |
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_fullStr |
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_full_unstemmed |
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_short |
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_sort |
inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| topic |
Pulmonary and Respiratory Medicine |
| url |
http://dx.doi.org/10.1183/09031936.98.12020380 |
| publishDate |
1998 |
| physical |
380-386 |
| description |
<jats:p>Cigarette smoking is the most important cause of chronic obstructive pulmonary disease (COPD). Although the precise sequence of events that leads a smoker to experience airway obstruction is not completely clear, airway inflammation is a relevant factor. To investigate airway inflammation, 12 nonatopic smoking COPD patients with a forced expiratory volume in one second (FEV1) < or = 75% predicted and 10 normal nonsmoking subjects (NS) were studied with bronchoscopy and bronchial lavage (BL). Serum immunoglobulin (Ig)E levels of COPD patients correlated with the smoking history (r=0.7, p=0.008). In BL of COPD patients there was an increase of neutrophils (median, range) (COPD 62.6x10(3), 1.2-323, NS 1.35, 0-19.2, p=0.001), eosinophils (COPD 1.6, 0-6.9, NS 0.15, 0-3.7, p=0.035), the levels of interleukin (IL)-8 (COPD 1079 pg x mL(-1), 121-2,500, NS 20.4, 7.2-59, p=0.001), myeloperoxidase (MPO) (COPD 752 microg x L(-1), 11-5,500, NS 22.1, 8-70, p=0.001) and eosinophil cationic protein (ECP) (COPD 21.5 microg x L(-1), 1.8-161, NS 2, 1.8-4.9, p=0.001). Significant correlations were found in BL of COPD patients between IL-8 and neutrophils (p=0.02), MPO and neutrophils (p=0.02), IL-8 and MPO (p=0.0001) and ECP and eosinophils (p=0.02). In addition, the ratios between the BL levels of MPO and the number of neutrophils and between ECP levels and eosinophils were higher in COPD patients than in NS (p=0.03 and 0.01, respectively). These data suggest that cigarette smoke is associated with increased amounts of airway interleukin-8, a chemotactic factor for neutrophils and eosinophils. Recruited neutrophils and eosinophils are activated and they release increased amounts of inflammatory mediators capable of damaging the bronchial tissue.</jats:p> |
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| author | Pesci, A, Balbi, B, Majori, M, Cacciani, G, Bertacco, S, Alciato, P, Donner, CF |
| author_facet | Pesci, A, Balbi, B, Majori, M, Cacciani, G, Bertacco, S, Alciato, P, Donner, CF, Pesci, A, Balbi, B, Majori, M, Cacciani, G, Bertacco, S, Alciato, P, Donner, CF |
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| description | <jats:p>Cigarette smoking is the most important cause of chronic obstructive pulmonary disease (COPD). Although the precise sequence of events that leads a smoker to experience airway obstruction is not completely clear, airway inflammation is a relevant factor. To investigate airway inflammation, 12 nonatopic smoking COPD patients with a forced expiratory volume in one second (FEV1) < or = 75% predicted and 10 normal nonsmoking subjects (NS) were studied with bronchoscopy and bronchial lavage (BL). Serum immunoglobulin (Ig)E levels of COPD patients correlated with the smoking history (r=0.7, p=0.008). In BL of COPD patients there was an increase of neutrophils (median, range) (COPD 62.6x10(3), 1.2-323, NS 1.35, 0-19.2, p=0.001), eosinophils (COPD 1.6, 0-6.9, NS 0.15, 0-3.7, p=0.035), the levels of interleukin (IL)-8 (COPD 1079 pg x mL(-1), 121-2,500, NS 20.4, 7.2-59, p=0.001), myeloperoxidase (MPO) (COPD 752 microg x L(-1), 11-5,500, NS 22.1, 8-70, p=0.001) and eosinophil cationic protein (ECP) (COPD 21.5 microg x L(-1), 1.8-161, NS 2, 1.8-4.9, p=0.001). Significant correlations were found in BL of COPD patients between IL-8 and neutrophils (p=0.02), MPO and neutrophils (p=0.02), IL-8 and MPO (p=0.0001) and ECP and eosinophils (p=0.02). In addition, the ratios between the BL levels of MPO and the number of neutrophils and between ECP levels and eosinophils were higher in COPD patients than in NS (p=0.03 and 0.01, respectively). These data suggest that cigarette smoke is associated with increased amounts of airway interleukin-8, a chemotactic factor for neutrophils and eosinophils. Recruited neutrophils and eosinophils are activated and they release increased amounts of inflammatory mediators capable of damaging the bronchial tissue.</jats:p> |
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| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
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| spelling | Pesci, A Balbi, B Majori, M Cacciani, G Bertacco, S Alciato, P Donner, CF 0903-1936 1399-3003 European Respiratory Society (ERS) Pulmonary and Respiratory Medicine http://dx.doi.org/10.1183/09031936.98.12020380 <jats:p>Cigarette smoking is the most important cause of chronic obstructive pulmonary disease (COPD). Although the precise sequence of events that leads a smoker to experience airway obstruction is not completely clear, airway inflammation is a relevant factor. To investigate airway inflammation, 12 nonatopic smoking COPD patients with a forced expiratory volume in one second (FEV1) < or = 75% predicted and 10 normal nonsmoking subjects (NS) were studied with bronchoscopy and bronchial lavage (BL). Serum immunoglobulin (Ig)E levels of COPD patients correlated with the smoking history (r=0.7, p=0.008). In BL of COPD patients there was an increase of neutrophils (median, range) (COPD 62.6x10(3), 1.2-323, NS 1.35, 0-19.2, p=0.001), eosinophils (COPD 1.6, 0-6.9, NS 0.15, 0-3.7, p=0.035), the levels of interleukin (IL)-8 (COPD 1079 pg x mL(-1), 121-2,500, NS 20.4, 7.2-59, p=0.001), myeloperoxidase (MPO) (COPD 752 microg x L(-1), 11-5,500, NS 22.1, 8-70, p=0.001) and eosinophil cationic protein (ECP) (COPD 21.5 microg x L(-1), 1.8-161, NS 2, 1.8-4.9, p=0.001). Significant correlations were found in BL of COPD patients between IL-8 and neutrophils (p=0.02), MPO and neutrophils (p=0.02), IL-8 and MPO (p=0.0001) and ECP and eosinophils (p=0.02). In addition, the ratios between the BL levels of MPO and the number of neutrophils and between ECP levels and eosinophils were higher in COPD patients than in NS (p=0.03 and 0.01, respectively). These data suggest that cigarette smoke is associated with increased amounts of airway interleukin-8, a chemotactic factor for neutrophils and eosinophils. Recruited neutrophils and eosinophils are activated and they release increased amounts of inflammatory mediators capable of damaging the bronchial tissue.</jats:p> Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease European Respiratory Journal |
| spellingShingle | Pesci, A, Balbi, B, Majori, M, Cacciani, G, Bertacco, S, Alciato, P, Donner, CF, European Respiratory Journal, Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease, Pulmonary and Respiratory Medicine |
| title | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_full | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_fullStr | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_full_unstemmed | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_short | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_sort | inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| title_unstemmed | Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease |
| topic | Pulmonary and Respiratory Medicine |
| url | http://dx.doi.org/10.1183/09031936.98.12020380 |