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Loss of hematopoietic stem cell self-renewal after bone marrow transplantation
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , |
| In: | Blood, 74, 1989, 2, S. 872-875 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Mauch, P Hellman, S Mauch, P Hellman, S |
|---|---|
| author |
Mauch, P Hellman, S |
| spellingShingle |
Mauch, P Hellman, S Blood Loss of hematopoietic stem cell self-renewal after bone marrow transplantation Cell Biology Hematology Immunology Biochemistry |
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mauch, p |
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Mauch, P Hellman, S 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v74.2.872.bloodjournal742872 <jats:p>The quality of long-term hematopoietic engraftment after bone marrow transplantation (BMT) has not been well characterized. Clinical autologous BMT involves removal of less than 5% of the total content of the recipient marrow followed by ablation of the remaining marrow and reinfusion. To study long-term consequences of transplanting limited numbers of BM stem cells further, we evaluated the hematopoietic reserve in recipient animals after transplantation of varying quantities of BM. Recipient animals demonstrated a donor BM cell dose- dependent decrease in stem cell content and self-renewal capacity that was not reflected in peripheral blood (PB) counts or BM cellularity. This decrease was observed after initial BM recovery and did not change with time after transplantation, demonstrating a permanent loss in BM self-renewal capacity. In addition, animals alive at 3 months, a time selected to allow BM recovery, also demonstrated a donor BM cell dose- dependent decrease in survival at 1 year. These results emphasize the importance of optimizing stem cell number in BMT.</jats:p> Loss of hematopoietic stem cell self-renewal after bone marrow transplantation Blood |
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DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 |
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American Society of Hematology, 1989 |
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American Society of Hematology, 1989 |
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0006-4971 1528-0020 |
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0006-4971 1528-0020 |
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1989 |
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| title |
Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_unstemmed |
Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_full |
Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_fullStr |
Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_full_unstemmed |
Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_short |
Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_sort |
loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood.v74.2.872.bloodjournal742872 |
| publishDate |
1989 |
| physical |
872-875 |
| description |
<jats:p>The quality of long-term hematopoietic engraftment after bone marrow transplantation (BMT) has not been well characterized. Clinical autologous BMT involves removal of less than 5% of the total content of the recipient marrow followed by ablation of the remaining marrow and reinfusion. To study long-term consequences of transplanting limited numbers of BM stem cells further, we evaluated the hematopoietic reserve in recipient animals after transplantation of varying quantities of BM. Recipient animals demonstrated a donor BM cell dose- dependent decrease in stem cell content and self-renewal capacity that was not reflected in peripheral blood (PB) counts or BM cellularity. This decrease was observed after initial BM recovery and did not change with time after transplantation, demonstrating a permanent loss in BM self-renewal capacity. In addition, animals alive at 3 months, a time selected to allow BM recovery, also demonstrated a donor BM cell dose- dependent decrease in survival at 1 year. These results emphasize the importance of optimizing stem cell number in BMT.</jats:p> |
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| description | <jats:p>The quality of long-term hematopoietic engraftment after bone marrow transplantation (BMT) has not been well characterized. Clinical autologous BMT involves removal of less than 5% of the total content of the recipient marrow followed by ablation of the remaining marrow and reinfusion. To study long-term consequences of transplanting limited numbers of BM stem cells further, we evaluated the hematopoietic reserve in recipient animals after transplantation of varying quantities of BM. Recipient animals demonstrated a donor BM cell dose- dependent decrease in stem cell content and self-renewal capacity that was not reflected in peripheral blood (PB) counts or BM cellularity. This decrease was observed after initial BM recovery and did not change with time after transplantation, demonstrating a permanent loss in BM self-renewal capacity. In addition, animals alive at 3 months, a time selected to allow BM recovery, also demonstrated a donor BM cell dose- dependent decrease in survival at 1 year. These results emphasize the importance of optimizing stem cell number in BMT.</jats:p> |
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| imprint | American Society of Hematology, 1989 |
| imprint_str_mv | American Society of Hematology, 1989 |
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| physical | 872-875 |
| publishDate | 1989 |
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| publisher | American Society of Hematology |
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| spelling | Mauch, P Hellman, S 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v74.2.872.bloodjournal742872 <jats:p>The quality of long-term hematopoietic engraftment after bone marrow transplantation (BMT) has not been well characterized. Clinical autologous BMT involves removal of less than 5% of the total content of the recipient marrow followed by ablation of the remaining marrow and reinfusion. To study long-term consequences of transplanting limited numbers of BM stem cells further, we evaluated the hematopoietic reserve in recipient animals after transplantation of varying quantities of BM. Recipient animals demonstrated a donor BM cell dose- dependent decrease in stem cell content and self-renewal capacity that was not reflected in peripheral blood (PB) counts or BM cellularity. This decrease was observed after initial BM recovery and did not change with time after transplantation, demonstrating a permanent loss in BM self-renewal capacity. In addition, animals alive at 3 months, a time selected to allow BM recovery, also demonstrated a donor BM cell dose- dependent decrease in survival at 1 year. These results emphasize the importance of optimizing stem cell number in BMT.</jats:p> Loss of hematopoietic stem cell self-renewal after bone marrow transplantation Blood |
| spellingShingle | Mauch, P, Hellman, S, Blood, Loss of hematopoietic stem cell self-renewal after bone marrow transplantation, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_full | Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_fullStr | Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_full_unstemmed | Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_short | Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_sort | loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| title_unstemmed | Loss of hematopoietic stem cell self-renewal after bone marrow transplantation |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood.v74.2.872.bloodjournal742872 |