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HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , |
| In: | Blood, 127, 2016, 25, S. 3237-3252 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Yang, Guang Buhrlage, Sara J. Tan, Li Liu, Xia Chen, Jie Xu, Lian Tsakmaklis, Nicholas Chen, Jiaji G. Patterson, Christopher J. Brown, Jennifer R. Castillo, Jorge J. Zhang, Wei Zhang, Xiaofeng Liu, Shuai Cohen, Philip Hunter, Zachary R. Gray, Nathanael Treon, Steven P. Yang, Guang Buhrlage, Sara J. Tan, Li Liu, Xia Chen, Jie Xu, Lian Tsakmaklis, Nicholas Chen, Jiaji G. Patterson, Christopher J. Brown, Jennifer R. Castillo, Jorge J. Zhang, Wei Zhang, Xiaofeng Liu, Shuai Cohen, Philip Hunter, Zachary R. Gray, Nathanael Treon, Steven P. |
|---|---|
| author |
Yang, Guang Buhrlage, Sara J. Tan, Li Liu, Xia Chen, Jie Xu, Lian Tsakmaklis, Nicholas Chen, Jiaji G. Patterson, Christopher J. Brown, Jennifer R. Castillo, Jorge J. Zhang, Wei Zhang, Xiaofeng Liu, Shuai Cohen, Philip Hunter, Zachary R. Gray, Nathanael Treon, Steven P. |
| spellingShingle |
Yang, Guang Buhrlage, Sara J. Tan, Li Liu, Xia Chen, Jie Xu, Lian Tsakmaklis, Nicholas Chen, Jiaji G. Patterson, Christopher J. Brown, Jennifer R. Castillo, Jorge J. Zhang, Wei Zhang, Xiaofeng Liu, Shuai Cohen, Philip Hunter, Zachary R. Gray, Nathanael Treon, Steven P. Blood HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib Cell Biology Hematology Immunology Biochemistry |
| author_sort |
yang, guang |
| spelling |
Yang, Guang Buhrlage, Sara J. Tan, Li Liu, Xia Chen, Jie Xu, Lian Tsakmaklis, Nicholas Chen, Jiaji G. Patterson, Christopher J. Brown, Jennifer R. Castillo, Jorge J. Zhang, Wei Zhang, Xiaofeng Liu, Shuai Cohen, Philip Hunter, Zachary R. Gray, Nathanael Treon, Steven P. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2016-01-695098 <jats:title>Key Points</jats:title> <jats:p>HCK transcription and activation is triggered by mutated MYD88, and is an important determinant of pro-survival signaling. HCK is also a target of ibrutinib, and inhibition of its kinase activity triggers apoptosis in mutated MYD88 cells.</jats:p> HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib Blood |
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American Society of Hematology, 2016 |
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American Society of Hematology, 2016 |
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| title |
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_unstemmed |
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_full |
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_fullStr |
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_full_unstemmed |
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_short |
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_sort |
hck is a survival determinant transactivated by mutated myd88, and a direct target of ibrutinib |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2016-01-695098 |
| publishDate |
2016 |
| physical |
3237-3252 |
| description |
<jats:title>Key Points</jats:title>
<jats:p>HCK transcription and activation is triggered by mutated MYD88, and is an important determinant of pro-survival signaling. HCK is also a target of ibrutinib, and inhibition of its kinase activity triggers apoptosis in mutated MYD88 cells.</jats:p> |
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| author | Yang, Guang, Buhrlage, Sara J., Tan, Li, Liu, Xia, Chen, Jie, Xu, Lian, Tsakmaklis, Nicholas, Chen, Jiaji G., Patterson, Christopher J., Brown, Jennifer R., Castillo, Jorge J., Zhang, Wei, Zhang, Xiaofeng, Liu, Shuai, Cohen, Philip, Hunter, Zachary R., Gray, Nathanael, Treon, Steven P. |
| author_facet | Yang, Guang, Buhrlage, Sara J., Tan, Li, Liu, Xia, Chen, Jie, Xu, Lian, Tsakmaklis, Nicholas, Chen, Jiaji G., Patterson, Christopher J., Brown, Jennifer R., Castillo, Jorge J., Zhang, Wei, Zhang, Xiaofeng, Liu, Shuai, Cohen, Philip, Hunter, Zachary R., Gray, Nathanael, Treon, Steven P., Yang, Guang, Buhrlage, Sara J., Tan, Li, Liu, Xia, Chen, Jie, Xu, Lian, Tsakmaklis, Nicholas, Chen, Jiaji G., Patterson, Christopher J., Brown, Jennifer R., Castillo, Jorge J., Zhang, Wei, Zhang, Xiaofeng, Liu, Shuai, Cohen, Philip, Hunter, Zachary R., Gray, Nathanael, Treon, Steven P. |
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| container_issue | 25 |
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| description | <jats:title>Key Points</jats:title> <jats:p>HCK transcription and activation is triggered by mutated MYD88, and is an important determinant of pro-survival signaling. HCK is also a target of ibrutinib, and inhibition of its kinase activity triggers apoptosis in mutated MYD88 cells.</jats:p> |
| doi_str_mv | 10.1182/blood-2016-01-695098 |
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| imprint | American Society of Hematology, 2016 |
| imprint_str_mv | American Society of Hematology, 2016 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
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| physical | 3237-3252 |
| publishDate | 2016 |
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| series | Blood |
| source_id | 49 |
| spelling | Yang, Guang Buhrlage, Sara J. Tan, Li Liu, Xia Chen, Jie Xu, Lian Tsakmaklis, Nicholas Chen, Jiaji G. Patterson, Christopher J. Brown, Jennifer R. Castillo, Jorge J. Zhang, Wei Zhang, Xiaofeng Liu, Shuai Cohen, Philip Hunter, Zachary R. Gray, Nathanael Treon, Steven P. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2016-01-695098 <jats:title>Key Points</jats:title> <jats:p>HCK transcription and activation is triggered by mutated MYD88, and is an important determinant of pro-survival signaling. HCK is also a target of ibrutinib, and inhibition of its kinase activity triggers apoptosis in mutated MYD88 cells.</jats:p> HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib Blood |
| spellingShingle | Yang, Guang, Buhrlage, Sara J., Tan, Li, Liu, Xia, Chen, Jie, Xu, Lian, Tsakmaklis, Nicholas, Chen, Jiaji G., Patterson, Christopher J., Brown, Jennifer R., Castillo, Jorge J., Zhang, Wei, Zhang, Xiaofeng, Liu, Shuai, Cohen, Philip, Hunter, Zachary R., Gray, Nathanael, Treon, Steven P., Blood, HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib, Cell Biology, Hematology, Immunology, Biochemistry |
| title | HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_full | HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_fullStr | HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_full_unstemmed | HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_short | HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| title_sort | hck is a survival determinant transactivated by mutated myd88, and a direct target of ibrutinib |
| title_unstemmed | HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2016-01-695098 |