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Yu, Ying Flint, Alan F. Mulliken, John B. Wu, June K. Bischoff, Joyce Yu, Ying Flint, Alan F. Mulliken, John B. Wu, June K. Bischoff, Joyce |
|---|---|
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Yu, Ying Flint, Alan F. Mulliken, John B. Wu, June K. Bischoff, Joyce |
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Yu, Ying Flint, Alan F. Mulliken, John B. Wu, June K. Bischoff, Joyce Blood Endothelial progenitor cells in infantile hemangioma Cell Biology Hematology Immunology Biochemistry |
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yu, ying |
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Yu, Ying Flint, Alan F. Mulliken, John B. Wu, June K. Bischoff, Joyce 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-08-2859 <jats:title>Abstract</jats:title> <jats:p>Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood. Initial proliferation of hemangioma is characterized by clonal expansion of endothelial cells (ECs) and neovascularization. Here, we demonstrated mRNA encoding CD133-2, an important marker for endothelial progenitor cells (EPCs), predominantly in proliferating but not involuting or involuted hemangioma. Progenitor cells coexpressing CD133 and CD34 were detected by flow cytometry in 11 of 12 proliferating hemangioma specimens from children 3 to 24 months of age. Furthermore, in 4 proliferating hemangiomas, we showed that 0.14% to 1.6% of CD45– nucleated cells were EPCs that coexpressed CD133 and the EC marker KDR. This finding is consistent with the presence of KDR+ immature ECs in proliferating hemangioma. Our results suggest that EPCs contribute to the early growth of hemangioma. To our knowledge, this is the first study to show direct evidence of EPCs in a human vascular tumor.</jats:p> Endothelial progenitor cells in infantile hemangioma Blood |
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American Society of Hematology, 2004 |
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American Society of Hematology, 2004 |
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| title |
Endothelial progenitor cells in infantile hemangioma |
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Endothelial progenitor cells in infantile hemangioma |
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Endothelial progenitor cells in infantile hemangioma |
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Endothelial progenitor cells in infantile hemangioma |
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Endothelial progenitor cells in infantile hemangioma |
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Endothelial progenitor cells in infantile hemangioma |
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endothelial progenitor cells in infantile hemangioma |
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Cell Biology Hematology Immunology Biochemistry |
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http://dx.doi.org/10.1182/blood-2003-08-2859 |
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2004 |
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<jats:title>Abstract</jats:title>
<jats:p>Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood. Initial proliferation of hemangioma is characterized by clonal expansion of endothelial cells (ECs) and neovascularization. Here, we demonstrated mRNA encoding CD133-2, an important marker for endothelial progenitor cells (EPCs), predominantly in proliferating but not involuting or involuted hemangioma. Progenitor cells coexpressing CD133 and CD34 were detected by flow cytometry in 11 of 12 proliferating hemangioma specimens from children 3 to 24 months of age. Furthermore, in 4 proliferating hemangiomas, we showed that 0.14% to 1.6% of CD45– nucleated cells were EPCs that coexpressed CD133 and the EC marker KDR. This finding is consistent with the presence of KDR+ immature ECs in proliferating hemangioma. Our results suggest that EPCs contribute to the early growth of hemangioma. To our knowledge, this is the first study to show direct evidence of EPCs in a human vascular tumor.</jats:p> |
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| author | Yu, Ying, Flint, Alan F., Mulliken, John B., Wu, June K., Bischoff, Joyce |
| author_facet | Yu, Ying, Flint, Alan F., Mulliken, John B., Wu, June K., Bischoff, Joyce, Yu, Ying, Flint, Alan F., Mulliken, John B., Wu, June K., Bischoff, Joyce |
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| description | <jats:title>Abstract</jats:title> <jats:p>Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood. Initial proliferation of hemangioma is characterized by clonal expansion of endothelial cells (ECs) and neovascularization. Here, we demonstrated mRNA encoding CD133-2, an important marker for endothelial progenitor cells (EPCs), predominantly in proliferating but not involuting or involuted hemangioma. Progenitor cells coexpressing CD133 and CD34 were detected by flow cytometry in 11 of 12 proliferating hemangioma specimens from children 3 to 24 months of age. Furthermore, in 4 proliferating hemangiomas, we showed that 0.14% to 1.6% of CD45– nucleated cells were EPCs that coexpressed CD133 and the EC marker KDR. This finding is consistent with the presence of KDR+ immature ECs in proliferating hemangioma. Our results suggest that EPCs contribute to the early growth of hemangioma. To our knowledge, this is the first study to show direct evidence of EPCs in a human vascular tumor.</jats:p> |
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| spelling | Yu, Ying Flint, Alan F. Mulliken, John B. Wu, June K. Bischoff, Joyce 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2003-08-2859 <jats:title>Abstract</jats:title> <jats:p>Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood. Initial proliferation of hemangioma is characterized by clonal expansion of endothelial cells (ECs) and neovascularization. Here, we demonstrated mRNA encoding CD133-2, an important marker for endothelial progenitor cells (EPCs), predominantly in proliferating but not involuting or involuted hemangioma. Progenitor cells coexpressing CD133 and CD34 were detected by flow cytometry in 11 of 12 proliferating hemangioma specimens from children 3 to 24 months of age. Furthermore, in 4 proliferating hemangiomas, we showed that 0.14% to 1.6% of CD45– nucleated cells were EPCs that coexpressed CD133 and the EC marker KDR. This finding is consistent with the presence of KDR+ immature ECs in proliferating hemangioma. Our results suggest that EPCs contribute to the early growth of hemangioma. To our knowledge, this is the first study to show direct evidence of EPCs in a human vascular tumor.</jats:p> Endothelial progenitor cells in infantile hemangioma Blood |
| spellingShingle | Yu, Ying, Flint, Alan F., Mulliken, John B., Wu, June K., Bischoff, Joyce, Blood, Endothelial progenitor cells in infantile hemangioma, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Endothelial progenitor cells in infantile hemangioma |
| title_full | Endothelial progenitor cells in infantile hemangioma |
| title_fullStr | Endothelial progenitor cells in infantile hemangioma |
| title_full_unstemmed | Endothelial progenitor cells in infantile hemangioma |
| title_short | Endothelial progenitor cells in infantile hemangioma |
| title_sort | endothelial progenitor cells in infantile hemangioma |
| title_unstemmed | Endothelial progenitor cells in infantile hemangioma |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2003-08-2859 |