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Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Blood, 101, 2003, 3, S. 970-976 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Hsu, Shu-Ching Wu, Chia-Cheng Han, Jiahuai Lai, Ming-Zong Hsu, Shu-Ching Wu, Chia-Cheng Han, Jiahuai Lai, Ming-Zong |
|---|---|
| author |
Hsu, Shu-Ching Wu, Chia-Cheng Han, Jiahuai Lai, Ming-Zong |
| spellingShingle |
Hsu, Shu-Ching Wu, Chia-Cheng Han, Jiahuai Lai, Ming-Zong Blood Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development Cell Biology Hematology Immunology Biochemistry |
| author_sort |
hsu, shu-ching |
| spelling |
Hsu, Shu-Ching Wu, Chia-Cheng Han, Jiahuai Lai, Ming-Zong 1528-0020 0006-4971 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2002-03-0744 <jats:title>Abstract</jats:title><jats:p>Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)–activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal–regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p38 MAPK impaired CD4−CD8− thymocyte development and T-cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that, in addition to early thymocyte development, p38 is involved in positive selection.</jats:p> Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development Blood |
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10.1182/blood-2002-03-0744 |
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American Society of Hematology, 2003 |
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American Society of Hematology, 2003 |
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1528-0020 0006-4971 |
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| title |
Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_unstemmed |
Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_full |
Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_fullStr |
Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_full_unstemmed |
Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_short |
Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_sort |
involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2002-03-0744 |
| publishDate |
2003 |
| physical |
970-976 |
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<jats:title>Abstract</jats:title><jats:p>Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)–activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal–regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p38 MAPK impaired CD4−CD8− thymocyte development and T-cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that, in addition to early thymocyte development, p38 is involved in positive selection.</jats:p> |
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| author | Hsu, Shu-Ching, Wu, Chia-Cheng, Han, Jiahuai, Lai, Ming-Zong |
| author_facet | Hsu, Shu-Ching, Wu, Chia-Cheng, Han, Jiahuai, Lai, Ming-Zong, Hsu, Shu-Ching, Wu, Chia-Cheng, Han, Jiahuai, Lai, Ming-Zong |
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| description | <jats:title>Abstract</jats:title><jats:p>Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)–activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal–regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p38 MAPK impaired CD4−CD8− thymocyte development and T-cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that, in addition to early thymocyte development, p38 is involved in positive selection.</jats:p> |
| doi_str_mv | 10.1182/blood-2002-03-0744 |
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| imprint | American Society of Hematology, 2003 |
| imprint_str_mv | American Society of Hematology, 2003 |
| institution | DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| language | English |
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| physical | 970-976 |
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| spelling | Hsu, Shu-Ching Wu, Chia-Cheng Han, Jiahuai Lai, Ming-Zong 1528-0020 0006-4971 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2002-03-0744 <jats:title>Abstract</jats:title><jats:p>Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)–activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal–regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p38 MAPK impaired CD4−CD8− thymocyte development and T-cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that, in addition to early thymocyte development, p38 is involved in positive selection.</jats:p> Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development Blood |
| spellingShingle | Hsu, Shu-Ching, Wu, Chia-Cheng, Han, Jiahuai, Lai, Ming-Zong, Blood, Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_full | Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_fullStr | Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_full_unstemmed | Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_short | Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_sort | involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| title_unstemmed | Involvement of p38 mitogen–activated protein kinase in different stages of thymocyte development |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2002-03-0744 |