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Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Blood, 112, 2008, 8, S. 3484-3487 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
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| Schlagwörter: |
| author_facet |
Woolfrey, Ann E. Malhotra, Uma Harrington, Robert D. McNevin, John Manley, Thomas J. Riddell, Stanley R. Coombs, Robert W. Appelbaum, Frederick R. Corey, Larry Storb, Rainer Woolfrey, Ann E. Malhotra, Uma Harrington, Robert D. McNevin, John Manley, Thomas J. Riddell, Stanley R. Coombs, Robert W. Appelbaum, Frederick R. Corey, Larry Storb, Rainer |
|---|---|
| author |
Woolfrey, Ann E. Malhotra, Uma Harrington, Robert D. McNevin, John Manley, Thomas J. Riddell, Stanley R. Coombs, Robert W. Appelbaum, Frederick R. Corey, Larry Storb, Rainer |
| spellingShingle |
Woolfrey, Ann E. Malhotra, Uma Harrington, Robert D. McNevin, John Manley, Thomas J. Riddell, Stanley R. Coombs, Robert W. Appelbaum, Frederick R. Corey, Larry Storb, Rainer Blood Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation Cell Biology Hematology Immunology Biochemistry |
| author_sort |
woolfrey, ann e. |
| spelling |
Woolfrey, Ann E. Malhotra, Uma Harrington, Robert D. McNevin, John Manley, Thomas J. Riddell, Stanley R. Coombs, Robert W. Appelbaum, Frederick R. Corey, Larry Storb, Rainer 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-05-157511 <jats:title>Abstract</jats:title><jats:p>This study tested whether donor-derived HIV-specific immune responses could be detected when viral replication was completely suppressed by the continuous administration of highly active antiretroviral therapy (HAART). A regimen of fludarabine and 200 cGy total body irradiation was followed by infusion of allogeneic donor peripheral blood cells and posttransplantation cyclosporine and mycophenolate mofetil. Viral load, lymphocyte counts, and HIV-1–specific CD8+ cell immune responses were compared before and after hematopoietic cell transplantation (HCT). Uninterrupted administration of HAART was feasible during nonmyeloablative conditioning and after HCT. The HIV RNA remained undetectable and no HIV-associated infections were observed. CD8+ T-cell responses targeting multiple epitopes were detected before HCT. After HCT a different pattern of donor-derived HIV-specific CTL responses emerged by day +80, presumably primed in vivo. We conclude that allogeneic HCT offers the unique ability to characterize de novo HIV-1–specific immune responses. This clinical trial was registered at ClinicalTrials.gov (identifier: NCT00112593).</jats:p> Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation Blood |
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10.1182/blood-2008-05-157511 |
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American Society of Hematology, 2008 |
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American Society of Hematology, 2008 |
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| title |
Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_unstemmed |
Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_full |
Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_fullStr |
Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_full_unstemmed |
Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_short |
Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_sort |
generation of hiv-1–specific cd8+ cell responses following allogeneic hematopoietic cell transplantation |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2008-05-157511 |
| publishDate |
2008 |
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3484-3487 |
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<jats:title>Abstract</jats:title><jats:p>This study tested whether donor-derived HIV-specific immune responses could be detected when viral replication was completely suppressed by the continuous administration of highly active antiretroviral therapy (HAART). A regimen of fludarabine and 200 cGy total body irradiation was followed by infusion of allogeneic donor peripheral blood cells and posttransplantation cyclosporine and mycophenolate mofetil. Viral load, lymphocyte counts, and HIV-1–specific CD8+ cell immune responses were compared before and after hematopoietic cell transplantation (HCT). Uninterrupted administration of HAART was feasible during nonmyeloablative conditioning and after HCT. The HIV RNA remained undetectable and no HIV-associated infections were observed. CD8+ T-cell responses targeting multiple epitopes were detected before HCT. After HCT a different pattern of donor-derived HIV-specific CTL responses emerged by day +80, presumably primed in vivo. We conclude that allogeneic HCT offers the unique ability to characterize de novo HIV-1–specific immune responses. This clinical trial was registered at ClinicalTrials.gov (identifier: NCT00112593).</jats:p> |
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| author | Woolfrey, Ann E., Malhotra, Uma, Harrington, Robert D., McNevin, John, Manley, Thomas J., Riddell, Stanley R., Coombs, Robert W., Appelbaum, Frederick R., Corey, Larry, Storb, Rainer |
| author_facet | Woolfrey, Ann E., Malhotra, Uma, Harrington, Robert D., McNevin, John, Manley, Thomas J., Riddell, Stanley R., Coombs, Robert W., Appelbaum, Frederick R., Corey, Larry, Storb, Rainer, Woolfrey, Ann E., Malhotra, Uma, Harrington, Robert D., McNevin, John, Manley, Thomas J., Riddell, Stanley R., Coombs, Robert W., Appelbaum, Frederick R., Corey, Larry, Storb, Rainer |
| author_sort | woolfrey, ann e. |
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| description | <jats:title>Abstract</jats:title><jats:p>This study tested whether donor-derived HIV-specific immune responses could be detected when viral replication was completely suppressed by the continuous administration of highly active antiretroviral therapy (HAART). A regimen of fludarabine and 200 cGy total body irradiation was followed by infusion of allogeneic donor peripheral blood cells and posttransplantation cyclosporine and mycophenolate mofetil. Viral load, lymphocyte counts, and HIV-1–specific CD8+ cell immune responses were compared before and after hematopoietic cell transplantation (HCT). Uninterrupted administration of HAART was feasible during nonmyeloablative conditioning and after HCT. The HIV RNA remained undetectable and no HIV-associated infections were observed. CD8+ T-cell responses targeting multiple epitopes were detected before HCT. After HCT a different pattern of donor-derived HIV-specific CTL responses emerged by day +80, presumably primed in vivo. We conclude that allogeneic HCT offers the unique ability to characterize de novo HIV-1–specific immune responses. This clinical trial was registered at ClinicalTrials.gov (identifier: NCT00112593).</jats:p> |
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| imprint_str_mv | American Society of Hematology, 2008 |
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| spelling | Woolfrey, Ann E. Malhotra, Uma Harrington, Robert D. McNevin, John Manley, Thomas J. Riddell, Stanley R. Coombs, Robert W. Appelbaum, Frederick R. Corey, Larry Storb, Rainer 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-05-157511 <jats:title>Abstract</jats:title><jats:p>This study tested whether donor-derived HIV-specific immune responses could be detected when viral replication was completely suppressed by the continuous administration of highly active antiretroviral therapy (HAART). A regimen of fludarabine and 200 cGy total body irradiation was followed by infusion of allogeneic donor peripheral blood cells and posttransplantation cyclosporine and mycophenolate mofetil. Viral load, lymphocyte counts, and HIV-1–specific CD8+ cell immune responses were compared before and after hematopoietic cell transplantation (HCT). Uninterrupted administration of HAART was feasible during nonmyeloablative conditioning and after HCT. The HIV RNA remained undetectable and no HIV-associated infections were observed. CD8+ T-cell responses targeting multiple epitopes were detected before HCT. After HCT a different pattern of donor-derived HIV-specific CTL responses emerged by day +80, presumably primed in vivo. We conclude that allogeneic HCT offers the unique ability to characterize de novo HIV-1–specific immune responses. This clinical trial was registered at ClinicalTrials.gov (identifier: NCT00112593).</jats:p> Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation Blood |
| spellingShingle | Woolfrey, Ann E., Malhotra, Uma, Harrington, Robert D., McNevin, John, Manley, Thomas J., Riddell, Stanley R., Coombs, Robert W., Appelbaum, Frederick R., Corey, Larry, Storb, Rainer, Blood, Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_full | Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_fullStr | Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_full_unstemmed | Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_short | Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_sort | generation of hiv-1–specific cd8+ cell responses following allogeneic hematopoietic cell transplantation |
| title_unstemmed | Generation of HIV-1–specific CD8+ cell responses following allogeneic hematopoietic cell transplantation |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2008-05-157511 |