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Distinct roles of helper T-cell subsets in a systemic autoimmune disease
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| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Blood, 113, 2009, 2, S. 389-395 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Hoyer, Katrina K. Kuswanto, Wilson F. Gallo, Eugenio Abbas, Abul K. Hoyer, Katrina K. Kuswanto, Wilson F. Gallo, Eugenio Abbas, Abul K. |
|---|---|
| author |
Hoyer, Katrina K. Kuswanto, Wilson F. Gallo, Eugenio Abbas, Abul K. |
| spellingShingle |
Hoyer, Katrina K. Kuswanto, Wilson F. Gallo, Eugenio Abbas, Abul K. Blood Distinct roles of helper T-cell subsets in a systemic autoimmune disease Cell Biology Hematology Immunology Biochemistry |
| author_sort |
hoyer, katrina k. |
| spelling |
Hoyer, Katrina K. Kuswanto, Wilson F. Gallo, Eugenio Abbas, Abul K. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-04-153346 <jats:title>Abstract</jats:title><jats:p>Imbalance of T-helper cell (Th) differentiation and subsequent cytokine dysregulation is implicated in inflammatory and autoimmune diseases. In particular, 2 cytokines produced by different Th cell populations, interferon-γ (IFN-γ) and interleukin-17 (IL-17), have been shown to play a critical role in autoimmunity. We have examined the roles of these cytokines in a mouse model of systemic autoimmunity resulting from the deletion of IL-2 in which autoimmune hemolytic anemia (AIHA) is a prominent feature. We demonstrate that, in IL-2–knockout (KO) BALB/c mice, elimination of the Th1 cytokine, IFN-γ, delays the development of AIHA. Further, CD4+ T cells from IL-2/IFN-γ–KO mice produce elevated levels of IL-17 compared with wild-type (WT) and IL-2–KO, and these mice eventually develop intestinal inflammation. In contrast, elimination of the Th17 cytokine, IL-17, from IL-2–KO mice fails to suppress early acute AIHA development. These results suggest that in a systemic autoimmune disease with multiple manifestations, Th1 cells drive the early autoantibody response and IL-17–producing cells may be responsible for the more chronic tissue inflammation.</jats:p> Distinct roles of helper T-cell subsets in a systemic autoimmune disease Blood |
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10.1182/blood-2008-04-153346 |
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American Society of Hematology, 2009 |
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| title |
Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_unstemmed |
Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_full |
Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_fullStr |
Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_full_unstemmed |
Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_short |
Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_sort |
distinct roles of helper t-cell subsets in a systemic autoimmune disease |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood-2008-04-153346 |
| publishDate |
2009 |
| physical |
389-395 |
| description |
<jats:title>Abstract</jats:title><jats:p>Imbalance of T-helper cell (Th) differentiation and subsequent cytokine dysregulation is implicated in inflammatory and autoimmune diseases. In particular, 2 cytokines produced by different Th cell populations, interferon-γ (IFN-γ) and interleukin-17 (IL-17), have been shown to play a critical role in autoimmunity. We have examined the roles of these cytokines in a mouse model of systemic autoimmunity resulting from the deletion of IL-2 in which autoimmune hemolytic anemia (AIHA) is a prominent feature. We demonstrate that, in IL-2–knockout (KO) BALB/c mice, elimination of the Th1 cytokine, IFN-γ, delays the development of AIHA. Further, CD4+ T cells from IL-2/IFN-γ–KO mice produce elevated levels of IL-17 compared with wild-type (WT) and IL-2–KO, and these mice eventually develop intestinal inflammation. In contrast, elimination of the Th17 cytokine, IL-17, from IL-2–KO mice fails to suppress early acute AIHA development. These results suggest that in a systemic autoimmune disease with multiple manifestations, Th1 cells drive the early autoantibody response and IL-17–producing cells may be responsible for the more chronic tissue inflammation.</jats:p> |
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| author | Hoyer, Katrina K., Kuswanto, Wilson F., Gallo, Eugenio, Abbas, Abul K. |
| author_facet | Hoyer, Katrina K., Kuswanto, Wilson F., Gallo, Eugenio, Abbas, Abul K., Hoyer, Katrina K., Kuswanto, Wilson F., Gallo, Eugenio, Abbas, Abul K. |
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| description | <jats:title>Abstract</jats:title><jats:p>Imbalance of T-helper cell (Th) differentiation and subsequent cytokine dysregulation is implicated in inflammatory and autoimmune diseases. In particular, 2 cytokines produced by different Th cell populations, interferon-γ (IFN-γ) and interleukin-17 (IL-17), have been shown to play a critical role in autoimmunity. We have examined the roles of these cytokines in a mouse model of systemic autoimmunity resulting from the deletion of IL-2 in which autoimmune hemolytic anemia (AIHA) is a prominent feature. We demonstrate that, in IL-2–knockout (KO) BALB/c mice, elimination of the Th1 cytokine, IFN-γ, delays the development of AIHA. Further, CD4+ T cells from IL-2/IFN-γ–KO mice produce elevated levels of IL-17 compared with wild-type (WT) and IL-2–KO, and these mice eventually develop intestinal inflammation. In contrast, elimination of the Th17 cytokine, IL-17, from IL-2–KO mice fails to suppress early acute AIHA development. These results suggest that in a systemic autoimmune disease with multiple manifestations, Th1 cells drive the early autoantibody response and IL-17–producing cells may be responsible for the more chronic tissue inflammation.</jats:p> |
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| imprint | American Society of Hematology, 2009 |
| imprint_str_mv | American Society of Hematology, 2009 |
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| spelling | Hoyer, Katrina K. Kuswanto, Wilson F. Gallo, Eugenio Abbas, Abul K. 0006-4971 1528-0020 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood-2008-04-153346 <jats:title>Abstract</jats:title><jats:p>Imbalance of T-helper cell (Th) differentiation and subsequent cytokine dysregulation is implicated in inflammatory and autoimmune diseases. In particular, 2 cytokines produced by different Th cell populations, interferon-γ (IFN-γ) and interleukin-17 (IL-17), have been shown to play a critical role in autoimmunity. We have examined the roles of these cytokines in a mouse model of systemic autoimmunity resulting from the deletion of IL-2 in which autoimmune hemolytic anemia (AIHA) is a prominent feature. We demonstrate that, in IL-2–knockout (KO) BALB/c mice, elimination of the Th1 cytokine, IFN-γ, delays the development of AIHA. Further, CD4+ T cells from IL-2/IFN-γ–KO mice produce elevated levels of IL-17 compared with wild-type (WT) and IL-2–KO, and these mice eventually develop intestinal inflammation. In contrast, elimination of the Th17 cytokine, IL-17, from IL-2–KO mice fails to suppress early acute AIHA development. These results suggest that in a systemic autoimmune disease with multiple manifestations, Th1 cells drive the early autoantibody response and IL-17–producing cells may be responsible for the more chronic tissue inflammation.</jats:p> Distinct roles of helper T-cell subsets in a systemic autoimmune disease Blood |
| spellingShingle | Hoyer, Katrina K., Kuswanto, Wilson F., Gallo, Eugenio, Abbas, Abul K., Blood, Distinct roles of helper T-cell subsets in a systemic autoimmune disease, Cell Biology, Hematology, Immunology, Biochemistry |
| title | Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_full | Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_fullStr | Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_full_unstemmed | Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_short | Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| title_sort | distinct roles of helper t-cell subsets in a systemic autoimmune disease |
| title_unstemmed | Distinct roles of helper T-cell subsets in a systemic autoimmune disease |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood-2008-04-153346 |