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Older patients/older donors: choosing wisely
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| Zeitschriftentitel: | Hematology |
|---|---|
| Personen und Körperschaften: | |
| In: | Hematology, 2013, 2013, 1, S. 70-75 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Artz, Andrew S. Artz, Andrew S. |
|---|---|
| author |
Artz, Andrew S. |
| spellingShingle |
Artz, Andrew S. Hematology Older patients/older donors: choosing wisely Hematology |
| author_sort |
artz, andrew s. |
| spelling |
Artz, Andrew S. 1520-4391 1520-4383 American Society of Hematology Hematology http://dx.doi.org/10.1182/asheducation.v2013.1.70.3850587 <jats:p>Two lingering problems regarding transplantation in older adults have been how to select patients appropriately and whether to use older sibling donors. Allogeneic hematopoietic cell transplantation (HCT) of older patients may result in long-term survival due to GVL, but the data remain observational and mostly restricted to those 50 to 69 years of age. Patients with excellent performance status and low comorbidity have the best long-term survival after HCT. Novel measures of health status such as self-report or performance-based functional measures allow “staging the age” and may inform candidacy for less robust patients. Older matched sibling donors should be preferred over matched unrelated donors (MUDs) because outcomes are equivalent to superior for matched sibling donors compared with MUD. However, MUDs also achieve acceptable outcomes and long-term disease control. An alternative donor can be considered based on institutional protocols and expertise. Very limited information is available in patients or related donors 70 years of age and older. Future efforts to more completely characterize patient health status before transplantation will allow better application of HCT in older adults.</jats:p> Older patients/older donors: choosing wisely Hematology |
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American Society of Hematology, 2013 |
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American Society of Hematology, 2013 |
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Hematology |
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| title |
Older patients/older donors: choosing wisely |
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Older patients/older donors: choosing wisely |
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Older patients/older donors: choosing wisely |
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Older patients/older donors: choosing wisely |
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Older patients/older donors: choosing wisely |
| title_short |
Older patients/older donors: choosing wisely |
| title_sort |
older patients/older donors: choosing wisely |
| topic |
Hematology |
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http://dx.doi.org/10.1182/asheducation.v2013.1.70.3850587 |
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2013 |
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70-75 |
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<jats:p>Two lingering problems regarding transplantation in older adults have been how to select patients appropriately and whether to use older sibling donors. Allogeneic hematopoietic cell transplantation (HCT) of older patients may result in long-term survival due to GVL, but the data remain observational and mostly restricted to those 50 to 69 years of age. Patients with excellent performance status and low comorbidity have the best long-term survival after HCT. Novel measures of health status such as self-report or performance-based functional measures allow “staging the age” and may inform candidacy for less robust patients. Older matched sibling donors should be preferred over matched unrelated donors (MUDs) because outcomes are equivalent to superior for matched sibling donors compared with MUD. However, MUDs also achieve acceptable outcomes and long-term disease control. An alternative donor can be considered based on institutional protocols and expertise. Very limited information is available in patients or related donors 70 years of age and older. Future efforts to more completely characterize patient health status before transplantation will allow better application of HCT in older adults.</jats:p> |
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| description | <jats:p>Two lingering problems regarding transplantation in older adults have been how to select patients appropriately and whether to use older sibling donors. Allogeneic hematopoietic cell transplantation (HCT) of older patients may result in long-term survival due to GVL, but the data remain observational and mostly restricted to those 50 to 69 years of age. Patients with excellent performance status and low comorbidity have the best long-term survival after HCT. Novel measures of health status such as self-report or performance-based functional measures allow “staging the age” and may inform candidacy for less robust patients. Older matched sibling donors should be preferred over matched unrelated donors (MUDs) because outcomes are equivalent to superior for matched sibling donors compared with MUD. However, MUDs also achieve acceptable outcomes and long-term disease control. An alternative donor can be considered based on institutional protocols and expertise. Very limited information is available in patients or related donors 70 years of age and older. Future efforts to more completely characterize patient health status before transplantation will allow better application of HCT in older adults.</jats:p> |
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| source_id | 49 |
| spelling | Artz, Andrew S. 1520-4391 1520-4383 American Society of Hematology Hematology http://dx.doi.org/10.1182/asheducation.v2013.1.70.3850587 <jats:p>Two lingering problems regarding transplantation in older adults have been how to select patients appropriately and whether to use older sibling donors. Allogeneic hematopoietic cell transplantation (HCT) of older patients may result in long-term survival due to GVL, but the data remain observational and mostly restricted to those 50 to 69 years of age. Patients with excellent performance status and low comorbidity have the best long-term survival after HCT. Novel measures of health status such as self-report or performance-based functional measures allow “staging the age” and may inform candidacy for less robust patients. Older matched sibling donors should be preferred over matched unrelated donors (MUDs) because outcomes are equivalent to superior for matched sibling donors compared with MUD. However, MUDs also achieve acceptable outcomes and long-term disease control. An alternative donor can be considered based on institutional protocols and expertise. Very limited information is available in patients or related donors 70 years of age and older. Future efforts to more completely characterize patient health status before transplantation will allow better application of HCT in older adults.</jats:p> Older patients/older donors: choosing wisely Hematology |
| spellingShingle | Artz, Andrew S., Hematology, Older patients/older donors: choosing wisely, Hematology |
| title | Older patients/older donors: choosing wisely |
| title_full | Older patients/older donors: choosing wisely |
| title_fullStr | Older patients/older donors: choosing wisely |
| title_full_unstemmed | Older patients/older donors: choosing wisely |
| title_short | Older patients/older donors: choosing wisely |
| title_sort | older patients/older donors: choosing wisely |
| title_unstemmed | Older patients/older donors: choosing wisely |
| topic | Hematology |
| url | http://dx.doi.org/10.1182/asheducation.v2013.1.70.3850587 |