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Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects
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| Zeitschriftentitel: | Journal of Applied Biomaterials & Functional Materials |
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| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Applied Biomaterials & Functional Materials, 17, 2019, 1, S. 228080001882049 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Tebyanian, Hamid Norahan, Mohammad Hadi Eyni, Hossein Movahedin, Mansoureh Mortazavi, SM Javad Karami, Ali Nourani, Mohammad Reza Baheiraei, Nafiseh Tebyanian, Hamid Norahan, Mohammad Hadi Eyni, Hossein Movahedin, Mansoureh Mortazavi, SM Javad Karami, Ali Nourani, Mohammad Reza Baheiraei, Nafiseh |
|---|---|
| author |
Tebyanian, Hamid Norahan, Mohammad Hadi Eyni, Hossein Movahedin, Mansoureh Mortazavi, SM Javad Karami, Ali Nourani, Mohammad Reza Baheiraei, Nafiseh |
| spellingShingle |
Tebyanian, Hamid Norahan, Mohammad Hadi Eyni, Hossein Movahedin, Mansoureh Mortazavi, SM Javad Karami, Ali Nourani, Mohammad Reza Baheiraei, Nafiseh Journal of Applied Biomaterials & Functional Materials Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects Biomedical Engineering Biomaterials General Medicine Bioengineering Biophysics |
| author_sort |
tebyanian, hamid |
| spelling |
Tebyanian, Hamid Norahan, Mohammad Hadi Eyni, Hossein Movahedin, Mansoureh Mortazavi, SM Javad Karami, Ali Nourani, Mohammad Reza Baheiraei, Nafiseh 2280-8000 2280-8000 SAGE Publications Biomedical Engineering Biomaterials General Medicine Bioengineering Biophysics http://dx.doi.org/10.1177/2280800018820490 <jats:p>Bone defects remain a significant health issue and a major cause of morbidity in elderly patients. Composites based on collagen/calcium phosphate have been widely used for bone repair in clinical applications, owing to their comparability to bone extracellular matrix. This study aimed to evaluate the effects of a scaffold of collagen/calcium phosphate (COL/β-TCP) on bone formation to assess its potential use as a bone substitute to repair bone defects. Bilateral full-thickness critically sized calvarial defects (8 mm in diameter) were created in New Zealand white rabbits and treated with COL/β-TCP or COL scaffolds. One defect was also left unfilled as a control. Bone regeneration was assessed through histological evaluation using hematoxylin and eosin and Masson’s trichrome staining after 4 and 8 weeks. Alizarin Red staining was also utilized to observe the mineralization process. Our findings indicated that COL/β-TCP implantation could better enhance bone regeneration than COL and exhibited both new bone growth and scaffold material degradation.</jats:p> Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects Journal of Applied Biomaterials & Functional Materials |
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| title |
Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_unstemmed |
Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_full |
Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_fullStr |
Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_full_unstemmed |
Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_short |
Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_sort |
effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| topic |
Biomedical Engineering Biomaterials General Medicine Bioengineering Biophysics |
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http://dx.doi.org/10.1177/2280800018820490 |
| publishDate |
2019 |
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228080001882049 |
| description |
<jats:p>Bone defects remain a significant health issue and a major cause of morbidity in elderly patients. Composites based on collagen/calcium phosphate have been widely used for bone repair in clinical applications, owing to their comparability to bone extracellular matrix. This study aimed to evaluate the effects of a scaffold of collagen/calcium phosphate (COL/β-TCP) on bone formation to assess its potential use as a bone substitute to repair bone defects. Bilateral full-thickness critically sized calvarial defects (8 mm in diameter) were created in New Zealand white rabbits and treated with COL/β-TCP or COL scaffolds. One defect was also left unfilled as a control. Bone regeneration was assessed through histological evaluation using hematoxylin and eosin and Masson’s trichrome staining after 4 and 8 weeks. Alizarin Red staining was also utilized to observe the mineralization process. Our findings indicated that COL/β-TCP implantation could better enhance bone regeneration than COL and exhibited both new bone growth and scaffold material degradation.</jats:p> |
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| author | Tebyanian, Hamid, Norahan, Mohammad Hadi, Eyni, Hossein, Movahedin, Mansoureh, Mortazavi, SM Javad, Karami, Ali, Nourani, Mohammad Reza, Baheiraei, Nafiseh |
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| description | <jats:p>Bone defects remain a significant health issue and a major cause of morbidity in elderly patients. Composites based on collagen/calcium phosphate have been widely used for bone repair in clinical applications, owing to their comparability to bone extracellular matrix. This study aimed to evaluate the effects of a scaffold of collagen/calcium phosphate (COL/β-TCP) on bone formation to assess its potential use as a bone substitute to repair bone defects. Bilateral full-thickness critically sized calvarial defects (8 mm in diameter) were created in New Zealand white rabbits and treated with COL/β-TCP or COL scaffolds. One defect was also left unfilled as a control. Bone regeneration was assessed through histological evaluation using hematoxylin and eosin and Masson’s trichrome staining after 4 and 8 weeks. Alizarin Red staining was also utilized to observe the mineralization process. Our findings indicated that COL/β-TCP implantation could better enhance bone regeneration than COL and exhibited both new bone growth and scaffold material degradation.</jats:p> |
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| spelling | Tebyanian, Hamid Norahan, Mohammad Hadi Eyni, Hossein Movahedin, Mansoureh Mortazavi, SM Javad Karami, Ali Nourani, Mohammad Reza Baheiraei, Nafiseh 2280-8000 2280-8000 SAGE Publications Biomedical Engineering Biomaterials General Medicine Bioengineering Biophysics http://dx.doi.org/10.1177/2280800018820490 <jats:p>Bone defects remain a significant health issue and a major cause of morbidity in elderly patients. Composites based on collagen/calcium phosphate have been widely used for bone repair in clinical applications, owing to their comparability to bone extracellular matrix. This study aimed to evaluate the effects of a scaffold of collagen/calcium phosphate (COL/β-TCP) on bone formation to assess its potential use as a bone substitute to repair bone defects. Bilateral full-thickness critically sized calvarial defects (8 mm in diameter) were created in New Zealand white rabbits and treated with COL/β-TCP or COL scaffolds. One defect was also left unfilled as a control. Bone regeneration was assessed through histological evaluation using hematoxylin and eosin and Masson’s trichrome staining after 4 and 8 weeks. Alizarin Red staining was also utilized to observe the mineralization process. Our findings indicated that COL/β-TCP implantation could better enhance bone regeneration than COL and exhibited both new bone growth and scaffold material degradation.</jats:p> Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects Journal of Applied Biomaterials & Functional Materials |
| spellingShingle | Tebyanian, Hamid, Norahan, Mohammad Hadi, Eyni, Hossein, Movahedin, Mansoureh, Mortazavi, SM Javad, Karami, Ali, Nourani, Mohammad Reza, Baheiraei, Nafiseh, Journal of Applied Biomaterials & Functional Materials, Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects, Biomedical Engineering, Biomaterials, General Medicine, Bioengineering, Biophysics |
| title | Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_full | Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_fullStr | Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_full_unstemmed | Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_short | Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_sort | effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| title_unstemmed | Effects of collagen/β-tricalcium phosphate bone graft to regenerate bone in critically sized rabbit calvarial defects |
| topic | Biomedical Engineering, Biomaterials, General Medicine, Bioengineering, Biophysics |
| url | http://dx.doi.org/10.1177/2280800018820490 |