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Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix
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| Zeitschriftentitel: | Natural Product Communications |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Natural Product Communications, 15, 2020, 1, S. 1934578X1990119 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Bai, Hai-Ying Zheng, Wen-Hui Han, Shu Bao, Fang Sun, Li-Li Zhang, Kai-Xue Wang, Li-Yao Du, Hong Li, Yi-Meng Feng, Shi-Lan Nakabayashi, Ryo Yang, Zhi-Gang Bai, Hai-Ying Zheng, Wen-Hui Han, Shu Bao, Fang Sun, Li-Li Zhang, Kai-Xue Wang, Li-Yao Du, Hong Li, Yi-Meng Feng, Shi-Lan Nakabayashi, Ryo Yang, Zhi-Gang |
|---|---|
| author |
Bai, Hai-Ying Zheng, Wen-Hui Han, Shu Bao, Fang Sun, Li-Li Zhang, Kai-Xue Wang, Li-Yao Du, Hong Li, Yi-Meng Feng, Shi-Lan Nakabayashi, Ryo Yang, Zhi-Gang |
| spellingShingle |
Bai, Hai-Ying Zheng, Wen-Hui Han, Shu Bao, Fang Sun, Li-Li Zhang, Kai-Xue Wang, Li-Yao Du, Hong Li, Yi-Meng Feng, Shi-Lan Nakabayashi, Ryo Yang, Zhi-Gang Natural Product Communications Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
| author_sort |
bai, hai-ying |
| spelling |
Bai, Hai-Ying Zheng, Wen-Hui Han, Shu Bao, Fang Sun, Li-Li Zhang, Kai-Xue Wang, Li-Yao Du, Hong Li, Yi-Meng Feng, Shi-Lan Nakabayashi, Ryo Yang, Zhi-Gang 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x19901192 <jats:p> The Traditional Chinese Medicines (TCMs) Astragali Radix (AR) derived from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao and A. membranaceus (Fisch.) Bge., and Hedysari Radix (HR) derived from Hedysarum polybotrys Hand.-Mazz. (family Leguminosae) are well-known for increasing the tonic effects on “Qi.” A better insight into the specialized (secondary) metabolites is essential to understand the effects of TCM; however, such metabolites remain largely unknown. Here, we performed a metabolomics-based analysis using liquid chromatography-tandem mass spectrometry in 3 plant tissues—periderm, phloem, and xylem—to identify potential bioactive metabolites. Multivariate statistical analysis revealed 29 metabolites showing a significant difference between groups and 10 biomarker candidates of AR and HR. An anti-inflammatory assay showed that the xylem of both AR and HR and the phloem of HR showed higher anti-inflammatory activity than the positive control quercetin in terms of nitric oxide inhibition. </jats:p> Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines <i>Astragali Radix</i> and <i>Hedysari Radix</i> Natural Product Communications |
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10.1177/1934578x19901192 |
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SAGE Publications, 2020 |
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| title |
Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_unstemmed |
Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_full |
Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_fullStr |
Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_full_unstemmed |
Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_short |
Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_sort |
metabolomic determination of specialized metabolites using liquid chromatography-tandem mass spectrometry in the traditional chinese medicines <i>astragali radix</i> and <i>hedysari radix</i> |
| topic |
Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine |
| url |
http://dx.doi.org/10.1177/1934578x19901192 |
| publishDate |
2020 |
| physical |
1934578X1990119 |
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<jats:p> The Traditional Chinese Medicines (TCMs) Astragali Radix (AR) derived from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao and A. membranaceus (Fisch.) Bge., and Hedysari Radix (HR) derived from Hedysarum polybotrys Hand.-Mazz. (family Leguminosae) are well-known for increasing the tonic effects on “Qi.” A better insight into the specialized (secondary) metabolites is essential to understand the effects of TCM; however, such metabolites remain largely unknown. Here, we performed a metabolomics-based analysis using liquid chromatography-tandem mass spectrometry in 3 plant tissues—periderm, phloem, and xylem—to identify potential bioactive metabolites. Multivariate statistical analysis revealed 29 metabolites showing a significant difference between groups and 10 biomarker candidates of AR and HR. An anti-inflammatory assay showed that the xylem of both AR and HR and the phloem of HR showed higher anti-inflammatory activity than the positive control quercetin in terms of nitric oxide inhibition. </jats:p> |
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| author | Bai, Hai-Ying, Zheng, Wen-Hui, Han, Shu, Bao, Fang, Sun, Li-Li, Zhang, Kai-Xue, Wang, Li-Yao, Du, Hong, Li, Yi-Meng, Feng, Shi-Lan, Nakabayashi, Ryo, Yang, Zhi-Gang |
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| description | <jats:p> The Traditional Chinese Medicines (TCMs) Astragali Radix (AR) derived from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao and A. membranaceus (Fisch.) Bge., and Hedysari Radix (HR) derived from Hedysarum polybotrys Hand.-Mazz. (family Leguminosae) are well-known for increasing the tonic effects on “Qi.” A better insight into the specialized (secondary) metabolites is essential to understand the effects of TCM; however, such metabolites remain largely unknown. Here, we performed a metabolomics-based analysis using liquid chromatography-tandem mass spectrometry in 3 plant tissues—periderm, phloem, and xylem—to identify potential bioactive metabolites. Multivariate statistical analysis revealed 29 metabolites showing a significant difference between groups and 10 biomarker candidates of AR and HR. An anti-inflammatory assay showed that the xylem of both AR and HR and the phloem of HR showed higher anti-inflammatory activity than the positive control quercetin in terms of nitric oxide inhibition. </jats:p> |
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| spelling | Bai, Hai-Ying Zheng, Wen-Hui Han, Shu Bao, Fang Sun, Li-Li Zhang, Kai-Xue Wang, Li-Yao Du, Hong Li, Yi-Meng Feng, Shi-Lan Nakabayashi, Ryo Yang, Zhi-Gang 1934-578X 1555-9475 SAGE Publications Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine http://dx.doi.org/10.1177/1934578x19901192 <jats:p> The Traditional Chinese Medicines (TCMs) Astragali Radix (AR) derived from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao and A. membranaceus (Fisch.) Bge., and Hedysari Radix (HR) derived from Hedysarum polybotrys Hand.-Mazz. (family Leguminosae) are well-known for increasing the tonic effects on “Qi.” A better insight into the specialized (secondary) metabolites is essential to understand the effects of TCM; however, such metabolites remain largely unknown. Here, we performed a metabolomics-based analysis using liquid chromatography-tandem mass spectrometry in 3 plant tissues—periderm, phloem, and xylem—to identify potential bioactive metabolites. Multivariate statistical analysis revealed 29 metabolites showing a significant difference between groups and 10 biomarker candidates of AR and HR. An anti-inflammatory assay showed that the xylem of both AR and HR and the phloem of HR showed higher anti-inflammatory activity than the positive control quercetin in terms of nitric oxide inhibition. </jats:p> Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines <i>Astragali Radix</i> and <i>Hedysari Radix</i> Natural Product Communications |
| spellingShingle | Bai, Hai-Ying, Zheng, Wen-Hui, Han, Shu, Bao, Fang, Sun, Li-Li, Zhang, Kai-Xue, Wang, Li-Yao, Du, Hong, Li, Yi-Meng, Feng, Shi-Lan, Nakabayashi, Ryo, Yang, Zhi-Gang, Natural Product Communications, Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix, Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| title | Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_full | Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_fullStr | Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_full_unstemmed | Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_short | Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| title_sort | metabolomic determination of specialized metabolites using liquid chromatography-tandem mass spectrometry in the traditional chinese medicines <i>astragali radix</i> and <i>hedysari radix</i> |
| title_unstemmed | Metabolomic Determination of Specialized Metabolites Using Liquid Chromatography-Tandem Mass Spectrometry in the Traditional Chinese Medicines Astragali Radix and Hedysari Radix |
| topic | Complementary and alternative medicine, Plant Science, Drug Discovery, Pharmacology, General Medicine |
| url | http://dx.doi.org/10.1177/1934578x19901192 |