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Review: The role of the L-arginine-nitric oxide pathway in preeclampsia
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| Zeitschriftentitel: | Therapeutic Advances in Cardiovascular Disease |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Therapeutic Advances in Cardiovascular Disease, 2, 2008, 4, S. 261-275 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
López-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincon, Melvin Y. López, Marcos López-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincon, Melvin Y. López, Marcos |
|---|---|
| author |
López-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincon, Melvin Y. López, Marcos |
| spellingShingle |
López-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincon, Melvin Y. López, Marcos Therapeutic Advances in Cardiovascular Disease Review: The role of the L-arginine-nitric oxide pathway in preeclampsia Pharmacology (medical) Cardiology and Cardiovascular Medicine |
| author_sort |
lópez-jaramillo, patricio |
| spelling |
López-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincon, Melvin Y. López, Marcos 1753-9447 1753-9455 SAGE Publications Pharmacology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1177/1753944708092277 <jats:p> Preeclampsia (PE) is a major cause of maternal and perinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that clinical manifestations are caused by endothelial dysfunction. Nitric oxide (NO), which is synthesized from L-arginine in endothelial cells by the endothelial nitric oxide synthase (eNOS), provides a tonic dilator tone and regulates the adhesion of white blood cells and platelet aggregation. Alterations in the L-arginine-NO pathway have been associated with the development of PE. Various studies, reporting decreased, elevated or unchanged levels of nitrite (NO<jats:sub>2</jats:sub>) and nitrate (NO<jats:sub>3</jats:sub>), two end products of NO metabolism, have been published. Our group contributed to those contradictory reports describing cases of PE with both elevated and decreased levels of NO<jats:sub>2</jats:sub> and NO<jats:sub>3</jats:sub>. Apparently, diminished levels of NO could be related to deficiencies in the ingestion of dietary calcium associated to low levels of plasma ionic calcium, which is crucial to the eNOS' activity. Also, low levels of NO could be associated with the presence of eNOS polymorphisms or the presence of increased levels of ADMA, the endogenous inhibitor of NO. High levels of NO associated to low levels of cGMP suggest a decreased bioactivity of NO, which is probably related to an increased degradation of NO caused by a high production of superoxide in states of infection and inflammation. The present article analyses and reviews the reported paradoxical roles of the L-arginine-NO pathway in PE and gives a possible explanation for these results. </jats:p> Review: The role of the L-arginine-nitric oxide pathway in preeclampsia Therapeutic Advances in Cardiovascular Disease |
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| title |
Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_unstemmed |
Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_full |
Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_fullStr |
Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_full_unstemmed |
Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_short |
Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_sort |
review: the role of the l-arginine-nitric oxide pathway in preeclampsia |
| topic |
Pharmacology (medical) Cardiology and Cardiovascular Medicine |
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http://dx.doi.org/10.1177/1753944708092277 |
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2008 |
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261-275 |
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<jats:p> Preeclampsia (PE) is a major cause of maternal and perinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that clinical manifestations are caused by endothelial dysfunction. Nitric oxide (NO), which is synthesized from L-arginine in endothelial cells by the endothelial nitric oxide synthase (eNOS), provides a tonic dilator tone and regulates the adhesion of white blood cells and platelet aggregation. Alterations in the L-arginine-NO pathway have been associated with the development of PE. Various studies, reporting decreased, elevated or unchanged levels of nitrite (NO<jats:sub>2</jats:sub>) and nitrate (NO<jats:sub>3</jats:sub>), two end products of NO metabolism, have been published. Our group contributed to those contradictory reports describing cases of PE with both elevated and decreased levels of NO<jats:sub>2</jats:sub> and NO<jats:sub>3</jats:sub>. Apparently, diminished levels of NO could be related to deficiencies in the ingestion of dietary calcium associated to low levels of plasma ionic calcium, which is crucial to the eNOS' activity. Also, low levels of NO could be associated with the presence of eNOS polymorphisms or the presence of increased levels of ADMA, the endogenous inhibitor of NO. High levels of NO associated to low levels of cGMP suggest a decreased bioactivity of NO, which is probably related to an increased degradation of NO caused by a high production of superoxide in states of infection and inflammation. The present article analyses and reviews the reported paradoxical roles of the L-arginine-NO pathway in PE and gives a possible explanation for these results. </jats:p> |
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| description | <jats:p> Preeclampsia (PE) is a major cause of maternal and perinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that clinical manifestations are caused by endothelial dysfunction. Nitric oxide (NO), which is synthesized from L-arginine in endothelial cells by the endothelial nitric oxide synthase (eNOS), provides a tonic dilator tone and regulates the adhesion of white blood cells and platelet aggregation. Alterations in the L-arginine-NO pathway have been associated with the development of PE. Various studies, reporting decreased, elevated or unchanged levels of nitrite (NO<jats:sub>2</jats:sub>) and nitrate (NO<jats:sub>3</jats:sub>), two end products of NO metabolism, have been published. Our group contributed to those contradictory reports describing cases of PE with both elevated and decreased levels of NO<jats:sub>2</jats:sub> and NO<jats:sub>3</jats:sub>. Apparently, diminished levels of NO could be related to deficiencies in the ingestion of dietary calcium associated to low levels of plasma ionic calcium, which is crucial to the eNOS' activity. Also, low levels of NO could be associated with the presence of eNOS polymorphisms or the presence of increased levels of ADMA, the endogenous inhibitor of NO. High levels of NO associated to low levels of cGMP suggest a decreased bioactivity of NO, which is probably related to an increased degradation of NO caused by a high production of superoxide in states of infection and inflammation. The present article analyses and reviews the reported paradoxical roles of the L-arginine-NO pathway in PE and gives a possible explanation for these results. </jats:p> |
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| spelling | López-Jaramillo, Patricio Arenas, William D. García, Ronald G. Rincon, Melvin Y. López, Marcos 1753-9447 1753-9455 SAGE Publications Pharmacology (medical) Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1177/1753944708092277 <jats:p> Preeclampsia (PE) is a major cause of maternal and perinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that clinical manifestations are caused by endothelial dysfunction. Nitric oxide (NO), which is synthesized from L-arginine in endothelial cells by the endothelial nitric oxide synthase (eNOS), provides a tonic dilator tone and regulates the adhesion of white blood cells and platelet aggregation. Alterations in the L-arginine-NO pathway have been associated with the development of PE. Various studies, reporting decreased, elevated or unchanged levels of nitrite (NO<jats:sub>2</jats:sub>) and nitrate (NO<jats:sub>3</jats:sub>), two end products of NO metabolism, have been published. Our group contributed to those contradictory reports describing cases of PE with both elevated and decreased levels of NO<jats:sub>2</jats:sub> and NO<jats:sub>3</jats:sub>. Apparently, diminished levels of NO could be related to deficiencies in the ingestion of dietary calcium associated to low levels of plasma ionic calcium, which is crucial to the eNOS' activity. Also, low levels of NO could be associated with the presence of eNOS polymorphisms or the presence of increased levels of ADMA, the endogenous inhibitor of NO. High levels of NO associated to low levels of cGMP suggest a decreased bioactivity of NO, which is probably related to an increased degradation of NO caused by a high production of superoxide in states of infection and inflammation. The present article analyses and reviews the reported paradoxical roles of the L-arginine-NO pathway in PE and gives a possible explanation for these results. </jats:p> Review: The role of the L-arginine-nitric oxide pathway in preeclampsia Therapeutic Advances in Cardiovascular Disease |
| spellingShingle | López-Jaramillo, Patricio, Arenas, William D., García, Ronald G., Rincon, Melvin Y., López, Marcos, Therapeutic Advances in Cardiovascular Disease, Review: The role of the L-arginine-nitric oxide pathway in preeclampsia, Pharmacology (medical), Cardiology and Cardiovascular Medicine |
| title | Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_full | Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_fullStr | Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_full_unstemmed | Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_short | Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| title_sort | review: the role of the l-arginine-nitric oxide pathway in preeclampsia |
| title_unstemmed | Review: The role of the L-arginine-nitric oxide pathway in preeclampsia |
| topic | Pharmacology (medical), Cardiology and Cardiovascular Medicine |
| url | http://dx.doi.org/10.1177/1753944708092277 |