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Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review
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| Zeitschriftentitel: | Journal of International Medical Research |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of International Medical Research, 36, 2008, 6, S. 1149-1160 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Huang, K Wu, LD Huang, K Wu, LD |
|---|---|
| author |
Huang, K Wu, LD |
| spellingShingle |
Huang, K Wu, LD Journal of International Medical Research Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review Biochemistry (medical) Cell Biology Biochemistry General Medicine |
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huang, k |
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Huang, K Wu, LD 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/147323000803600601 <jats:p>Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the ‘A Disintegrin And Metalloproteinase with ThromboSpondin motifs’ (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.</jats:p> Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review Journal of International Medical Research |
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| title |
Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_unstemmed |
Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_full |
Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
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Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
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Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_short |
Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_sort |
aggrecanase and aggrecan degradation in osteoarthritis: a review |
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Biochemistry (medical) Cell Biology Biochemistry General Medicine |
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2008 |
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<jats:p>Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the ‘A Disintegrin And Metalloproteinase with ThromboSpondin motifs’ (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.</jats:p> |
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| description | <jats:p>Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the ‘A Disintegrin And Metalloproteinase with ThromboSpondin motifs’ (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.</jats:p> |
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| spelling | Huang, K Wu, LD 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/147323000803600601 <jats:p>Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the ‘A Disintegrin And Metalloproteinase with ThromboSpondin motifs’ (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.</jats:p> Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review Journal of International Medical Research |
| spellingShingle | Huang, K, Wu, LD, Journal of International Medical Research, Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review, Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| title | Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_full | Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_fullStr | Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_full_unstemmed | Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_short | Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| title_sort | aggrecanase and aggrecan degradation in osteoarthritis: a review |
| title_unstemmed | Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review |
| topic | Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| url | http://dx.doi.org/10.1177/147323000803600601 |