Eintrag weiter verarbeiten
Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation
Gespeichert in:
| Zeitschriftentitel: | Clinical and Applied Thrombosis/Hemostasis |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Clinical and Applied Thrombosis/Hemostasis, 24, 2018, 5, S. 718-723 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Jabati, Sallu Fareed, Jawed Liles, Jeffrey Otto, Abigail Hoppensteadt, Debra Bontekoe, Jack Phan, Trung Walborn, Amanda Syed, Mushabbar Jabati, Sallu Fareed, Jawed Liles, Jeffrey Otto, Abigail Hoppensteadt, Debra Bontekoe, Jack Phan, Trung Walborn, Amanda Syed, Mushabbar |
|---|---|
| author |
Jabati, Sallu Fareed, Jawed Liles, Jeffrey Otto, Abigail Hoppensteadt, Debra Bontekoe, Jack Phan, Trung Walborn, Amanda Syed, Mushabbar |
| spellingShingle |
Jabati, Sallu Fareed, Jawed Liles, Jeffrey Otto, Abigail Hoppensteadt, Debra Bontekoe, Jack Phan, Trung Walborn, Amanda Syed, Mushabbar Clinical and Applied Thrombosis/Hemostasis Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation Hematology General Medicine |
| author_sort |
jabati, sallu |
| spelling |
Jabati, Sallu Fareed, Jawed Liles, Jeffrey Otto, Abigail Hoppensteadt, Debra Bontekoe, Jack Phan, Trung Walborn, Amanda Syed, Mushabbar 1076-0296 1938-2723 SAGE Publications Hematology General Medicine http://dx.doi.org/10.1177/1076029618761006 <jats:p> The purpose of this study was to determine whether there are any differences in the levels of inflammatory, thrombotic, and collagen turnover biomarkers between individuals with atrial fibrillation (AF) and healthy volunteers. Circulating plasma levels of plasminogen activator inhibitor 1 (PAI-1), CD40-ligand (CD40-L), nucleosomes (which are indicators of cell death), C-reactive protein (CRP), procollagen III N-terminal propeptide (PIIINP), procollagen III C-terminal propeptide (PIIICP), procollagen I N-terminal propeptide, tissue plasminogen activator, and von Willebrand factor were analyzed as potential biomarkers of AF. Baseline plasma was collected from patients with AF prior to ablation surgery at Loyola University Medical Center. Individuals with AF had statistically significantly increased levels of PAI-1, CD40-L, and nucleosomes, when compared to the normal population ( P < .0001). Additionally, there was a statistically significant increase in the CRP ( P = .01), PIIINP ( P = .04), and PIIICP ( P = .0008) when compared to normal individuals. From this study, it is concluded that the prothrombotic, inflammatory, and collagen turnover biomarkers PAI-1, CD40-L, nucleosomes, CRP, PIIICP, and PIIINP are elevated in AF. </jats:p> Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation Clinical and Applied Thrombosis/Hemostasis |
| doi_str_mv |
10.1177/1076029618761006 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xMDc2MDI5NjE4NzYxMDA2 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xMDc2MDI5NjE4NzYxMDA2 |
| institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 |
| imprint |
SAGE Publications, 2018 |
| imprint_str_mv |
SAGE Publications, 2018 |
| issn |
1076-0296 1938-2723 |
| issn_str_mv |
1076-0296 1938-2723 |
| language |
English |
| mega_collection |
SAGE Publications (CrossRef) |
| match_str |
jabati2018biomarkersofinflammationthrombogenesisandcollagenturnoverinpatientswithatrialfibrillation |
| publishDateSort |
2018 |
| publisher |
SAGE Publications |
| recordtype |
ai |
| record_format |
ai |
| series |
Clinical and Applied Thrombosis/Hemostasis |
| source_id |
49 |
| title |
Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_unstemmed |
Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_full |
Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_fullStr |
Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_full_unstemmed |
Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_short |
Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_sort |
biomarkers of inflammation, thrombogenesis, and collagen turnover in patients with atrial fibrillation |
| topic |
Hematology General Medicine |
| url |
http://dx.doi.org/10.1177/1076029618761006 |
| publishDate |
2018 |
| physical |
718-723 |
| description |
<jats:p> The purpose of this study was to determine whether there are any differences in the levels of inflammatory, thrombotic, and collagen turnover biomarkers between individuals with atrial fibrillation (AF) and healthy volunteers. Circulating plasma levels of plasminogen activator inhibitor 1 (PAI-1), CD40-ligand (CD40-L), nucleosomes (which are indicators of cell death), C-reactive protein (CRP), procollagen III N-terminal propeptide (PIIINP), procollagen III C-terminal propeptide (PIIICP), procollagen I N-terminal propeptide, tissue plasminogen activator, and von Willebrand factor were analyzed as potential biomarkers of AF. Baseline plasma was collected from patients with AF prior to ablation surgery at Loyola University Medical Center. Individuals with AF had statistically significantly increased levels of PAI-1, CD40-L, and nucleosomes, when compared to the normal population ( P < .0001). Additionally, there was a statistically significant increase in the CRP ( P = .01), PIIINP ( P = .04), and PIIICP ( P = .0008) when compared to normal individuals. From this study, it is concluded that the prothrombotic, inflammatory, and collagen turnover biomarkers PAI-1, CD40-L, nucleosomes, CRP, PIIICP, and PIIINP are elevated in AF. </jats:p> |
| container_issue |
5 |
| container_start_page |
718 |
| container_title |
Clinical and Applied Thrombosis/Hemostasis |
| container_volume |
24 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792334331607253005 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:26:54.541Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Biomarkers+of+Inflammation%2C+Thrombogenesis%2C+and+Collagen+Turnover+in+Patients+With+Atrial+Fibrillation&rft.date=2018-07-01&genre=article&issn=1938-2723&volume=24&issue=5&spage=718&epage=723&pages=718-723&jtitle=Clinical+and+Applied+Thrombosis%2FHemostasis&atitle=Biomarkers+of+Inflammation%2C+Thrombogenesis%2C+and+Collagen+Turnover+in+Patients+With+Atrial+Fibrillation&aulast=Syed&aufirst=Mushabbar&rft_id=info%3Adoi%2F10.1177%2F1076029618761006&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792334331607253005 |
| author | Jabati, Sallu, Fareed, Jawed, Liles, Jeffrey, Otto, Abigail, Hoppensteadt, Debra, Bontekoe, Jack, Phan, Trung, Walborn, Amanda, Syed, Mushabbar |
| author_facet | Jabati, Sallu, Fareed, Jawed, Liles, Jeffrey, Otto, Abigail, Hoppensteadt, Debra, Bontekoe, Jack, Phan, Trung, Walborn, Amanda, Syed, Mushabbar, Jabati, Sallu, Fareed, Jawed, Liles, Jeffrey, Otto, Abigail, Hoppensteadt, Debra, Bontekoe, Jack, Phan, Trung, Walborn, Amanda, Syed, Mushabbar |
| author_sort | jabati, sallu |
| container_issue | 5 |
| container_start_page | 718 |
| container_title | Clinical and Applied Thrombosis/Hemostasis |
| container_volume | 24 |
| description | <jats:p> The purpose of this study was to determine whether there are any differences in the levels of inflammatory, thrombotic, and collagen turnover biomarkers between individuals with atrial fibrillation (AF) and healthy volunteers. Circulating plasma levels of plasminogen activator inhibitor 1 (PAI-1), CD40-ligand (CD40-L), nucleosomes (which are indicators of cell death), C-reactive protein (CRP), procollagen III N-terminal propeptide (PIIINP), procollagen III C-terminal propeptide (PIIICP), procollagen I N-terminal propeptide, tissue plasminogen activator, and von Willebrand factor were analyzed as potential biomarkers of AF. Baseline plasma was collected from patients with AF prior to ablation surgery at Loyola University Medical Center. Individuals with AF had statistically significantly increased levels of PAI-1, CD40-L, and nucleosomes, when compared to the normal population ( P < .0001). Additionally, there was a statistically significant increase in the CRP ( P = .01), PIIINP ( P = .04), and PIIICP ( P = .0008) when compared to normal individuals. From this study, it is concluded that the prothrombotic, inflammatory, and collagen turnover biomarkers PAI-1, CD40-L, nucleosomes, CRP, PIIICP, and PIIINP are elevated in AF. </jats:p> |
| doi_str_mv | 10.1177/1076029618761006 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8xMDc2MDI5NjE4NzYxMDA2 |
| imprint | SAGE Publications, 2018 |
| imprint_str_mv | SAGE Publications, 2018 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
| issn | 1076-0296, 1938-2723 |
| issn_str_mv | 1076-0296, 1938-2723 |
| language | English |
| last_indexed | 2024-03-01T14:26:54.541Z |
| match_str | jabati2018biomarkersofinflammationthrombogenesisandcollagenturnoverinpatientswithatrialfibrillation |
| mega_collection | SAGE Publications (CrossRef) |
| physical | 718-723 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | SAGE Publications |
| record_format | ai |
| recordtype | ai |
| series | Clinical and Applied Thrombosis/Hemostasis |
| source_id | 49 |
| spelling | Jabati, Sallu Fareed, Jawed Liles, Jeffrey Otto, Abigail Hoppensteadt, Debra Bontekoe, Jack Phan, Trung Walborn, Amanda Syed, Mushabbar 1076-0296 1938-2723 SAGE Publications Hematology General Medicine http://dx.doi.org/10.1177/1076029618761006 <jats:p> The purpose of this study was to determine whether there are any differences in the levels of inflammatory, thrombotic, and collagen turnover biomarkers between individuals with atrial fibrillation (AF) and healthy volunteers. Circulating plasma levels of plasminogen activator inhibitor 1 (PAI-1), CD40-ligand (CD40-L), nucleosomes (which are indicators of cell death), C-reactive protein (CRP), procollagen III N-terminal propeptide (PIIINP), procollagen III C-terminal propeptide (PIIICP), procollagen I N-terminal propeptide, tissue plasminogen activator, and von Willebrand factor were analyzed as potential biomarkers of AF. Baseline plasma was collected from patients with AF prior to ablation surgery at Loyola University Medical Center. Individuals with AF had statistically significantly increased levels of PAI-1, CD40-L, and nucleosomes, when compared to the normal population ( P < .0001). Additionally, there was a statistically significant increase in the CRP ( P = .01), PIIINP ( P = .04), and PIIICP ( P = .0008) when compared to normal individuals. From this study, it is concluded that the prothrombotic, inflammatory, and collagen turnover biomarkers PAI-1, CD40-L, nucleosomes, CRP, PIIICP, and PIIINP are elevated in AF. </jats:p> Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation Clinical and Applied Thrombosis/Hemostasis |
| spellingShingle | Jabati, Sallu, Fareed, Jawed, Liles, Jeffrey, Otto, Abigail, Hoppensteadt, Debra, Bontekoe, Jack, Phan, Trung, Walborn, Amanda, Syed, Mushabbar, Clinical and Applied Thrombosis/Hemostasis, Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation, Hematology, General Medicine |
| title | Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_full | Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_fullStr | Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_full_unstemmed | Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_short | Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| title_sort | biomarkers of inflammation, thrombogenesis, and collagen turnover in patients with atrial fibrillation |
| title_unstemmed | Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation |
| topic | Hematology, General Medicine |
| url | http://dx.doi.org/10.1177/1076029618761006 |