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Toxic effects of T-2 toxin on reproductive system in male mice
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| Zeitschriftentitel: | Toxicology and Industrial Health |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Toxicology and Industrial Health, 26, 2010, 1, S. 25-31 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Jian Ying Yang Yong Fa Zhang Ai Min Liang Xiang Feng Kong Yuan Xiao Li Kai Wang Ma Ai Hua Jing Shu Ying Feng Xiao Lan Qiao Jian Ying Yang Yong Fa Zhang Ai Min Liang Xiang Feng Kong Yuan Xiao Li Kai Wang Ma Ai Hua Jing Shu Ying Feng Xiao Lan Qiao |
|---|---|
| author |
Jian Ying Yang Yong Fa Zhang Ai Min Liang Xiang Feng Kong Yuan Xiao Li Kai Wang Ma Ai Hua Jing Shu Ying Feng Xiao Lan Qiao |
| spellingShingle |
Jian Ying Yang Yong Fa Zhang Ai Min Liang Xiang Feng Kong Yuan Xiao Li Kai Wang Ma Ai Hua Jing Shu Ying Feng Xiao Lan Qiao Toxicology and Industrial Health Toxic effects of T-2 toxin on reproductive system in male mice Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
| author_sort |
jian ying yang |
| spelling |
Jian Ying Yang Yong Fa Zhang Ai Min Liang Xiang Feng Kong Yuan Xiao Li Kai Wang Ma Ai Hua Jing Shu Ying Feng Xiao Lan Qiao 0748-2337 1477-0393 SAGE Publications Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology http://dx.doi.org/10.1177/0748233709354554 <jats:p> The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female mice after being exposed to intraperitoneal injection of T-2 toxin at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen quality, serum testosterone concentration and fertility of treated mice were assessed. The results showed that the number of abnormal spermatozoa increased significantly and a significant decrease in spermatozoa with integrated acrosome was observed in males treated with T-2 toxin at all doses, As well, the amount of live spermatozoa decreased significantly in mice treated with 10 and 15 mg/kg body weight T-2 toxin. Low pregnancy rate and high fetal resorption rate were observed when females were mated with T-2 toxin—exposed males. Testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration were significantly reduced in mice treated with T-2 toxin at all doses in a dose-dependent manner. In conclusion, these findings indicated that T-2 toxin presented toxic effects on reproductive system of adult male mice. </jats:p> Toxic effects of T-2 toxin on reproductive system in male mice Toxicology and Industrial Health |
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| title |
Toxic effects of T-2 toxin on reproductive system in male mice |
| title_unstemmed |
Toxic effects of T-2 toxin on reproductive system in male mice |
| title_full |
Toxic effects of T-2 toxin on reproductive system in male mice |
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Toxic effects of T-2 toxin on reproductive system in male mice |
| title_full_unstemmed |
Toxic effects of T-2 toxin on reproductive system in male mice |
| title_short |
Toxic effects of T-2 toxin on reproductive system in male mice |
| title_sort |
toxic effects of t-2 toxin on reproductive system in male mice |
| topic |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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http://dx.doi.org/10.1177/0748233709354554 |
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2010 |
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25-31 |
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<jats:p> The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female mice after being exposed to intraperitoneal injection of T-2 toxin at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen quality, serum testosterone concentration and fertility of treated mice were assessed. The results showed that the number of abnormal spermatozoa increased significantly and a significant decrease in spermatozoa with integrated acrosome was observed in males treated with T-2 toxin at all doses, As well, the amount of live spermatozoa decreased significantly in mice treated with 10 and 15 mg/kg body weight T-2 toxin. Low pregnancy rate and high fetal resorption rate were observed when females were mated with T-2 toxin—exposed males. Testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration were significantly reduced in mice treated with T-2 toxin at all doses in a dose-dependent manner. In conclusion, these findings indicated that T-2 toxin presented toxic effects on reproductive system of adult male mice. </jats:p> |
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| author | Jian Ying Yang, Yong Fa Zhang, Ai Min Liang, Xiang Feng Kong, Yuan Xiao Li, Kai Wang Ma, Ai Hua Jing, Shu Ying Feng, Xiao Lan Qiao |
| author_facet | Jian Ying Yang, Yong Fa Zhang, Ai Min Liang, Xiang Feng Kong, Yuan Xiao Li, Kai Wang Ma, Ai Hua Jing, Shu Ying Feng, Xiao Lan Qiao, Jian Ying Yang, Yong Fa Zhang, Ai Min Liang, Xiang Feng Kong, Yuan Xiao Li, Kai Wang Ma, Ai Hua Jing, Shu Ying Feng, Xiao Lan Qiao |
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| description | <jats:p> The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female mice after being exposed to intraperitoneal injection of T-2 toxin at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen quality, serum testosterone concentration and fertility of treated mice were assessed. The results showed that the number of abnormal spermatozoa increased significantly and a significant decrease in spermatozoa with integrated acrosome was observed in males treated with T-2 toxin at all doses, As well, the amount of live spermatozoa decreased significantly in mice treated with 10 and 15 mg/kg body weight T-2 toxin. Low pregnancy rate and high fetal resorption rate were observed when females were mated with T-2 toxin—exposed males. Testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration were significantly reduced in mice treated with T-2 toxin at all doses in a dose-dependent manner. In conclusion, these findings indicated that T-2 toxin presented toxic effects on reproductive system of adult male mice. </jats:p> |
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| spelling | Jian Ying Yang Yong Fa Zhang Ai Min Liang Xiang Feng Kong Yuan Xiao Li Kai Wang Ma Ai Hua Jing Shu Ying Feng Xiao Lan Qiao 0748-2337 1477-0393 SAGE Publications Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology http://dx.doi.org/10.1177/0748233709354554 <jats:p> The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female mice after being exposed to intraperitoneal injection of T-2 toxin at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen quality, serum testosterone concentration and fertility of treated mice were assessed. The results showed that the number of abnormal spermatozoa increased significantly and a significant decrease in spermatozoa with integrated acrosome was observed in males treated with T-2 toxin at all doses, As well, the amount of live spermatozoa decreased significantly in mice treated with 10 and 15 mg/kg body weight T-2 toxin. Low pregnancy rate and high fetal resorption rate were observed when females were mated with T-2 toxin—exposed males. Testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration were significantly reduced in mice treated with T-2 toxin at all doses in a dose-dependent manner. In conclusion, these findings indicated that T-2 toxin presented toxic effects on reproductive system of adult male mice. </jats:p> Toxic effects of T-2 toxin on reproductive system in male mice Toxicology and Industrial Health |
| spellingShingle | Jian Ying Yang, Yong Fa Zhang, Ai Min Liang, Xiang Feng Kong, Yuan Xiao Li, Kai Wang Ma, Ai Hua Jing, Shu Ying Feng, Xiao Lan Qiao, Toxicology and Industrial Health, Toxic effects of T-2 toxin on reproductive system in male mice, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Toxicology |
| title | Toxic effects of T-2 toxin on reproductive system in male mice |
| title_full | Toxic effects of T-2 toxin on reproductive system in male mice |
| title_fullStr | Toxic effects of T-2 toxin on reproductive system in male mice |
| title_full_unstemmed | Toxic effects of T-2 toxin on reproductive system in male mice |
| title_short | Toxic effects of T-2 toxin on reproductive system in male mice |
| title_sort | toxic effects of t-2 toxin on reproductive system in male mice |
| title_unstemmed | Toxic effects of T-2 toxin on reproductive system in male mice |
| topic | Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Toxicology |
| url | http://dx.doi.org/10.1177/0748233709354554 |