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N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications
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| Zeitschriftentitel: | Journal of International Medical Research |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Journal of International Medical Research, 41, 2013, 5, S. 1612-1621 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Ma, Gang Liao, Wei Qiu, Junke Su, Quanguan Fang, Yi Gu, Baochun Ma, Gang Liao, Wei Qiu, Junke Su, Quanguan Fang, Yi Gu, Baochun |
|---|---|
| author |
Ma, Gang Liao, Wei Qiu, Junke Su, Quanguan Fang, Yi Gu, Baochun |
| spellingShingle |
Ma, Gang Liao, Wei Qiu, Junke Su, Quanguan Fang, Yi Gu, Baochun Journal of International Medical Research N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| author_sort |
ma, gang |
| spelling |
Ma, Gang Liao, Wei Qiu, Junke Su, Quanguan Fang, Yi Gu, Baochun 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060513490085 <jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the relationship between plasma N-terminal prohormone B-type natriuretic peptide (NT-proBNP) and weaning outcomes, and the ability of NT-proBNP level to predict weaning success, in cancer patients with pulmonary complications undergoing noncardiac major surgeries. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Patients who were mechanically ventilated following postoperative respiratory failure were enrolled. NT-proBNP levels at the end of a 2-h spontaneous breathing trial were measured. Weaning was considered a success in patients who completed the trial and maintained spontaneous breathing following extubation for >48 h. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Out of 29 patients, 22 patients weaned successfully but weaning failed in 7 patients. Plasma NT-proBNP was significantly higher in the weaning failure group than in the weaning success group. For predicting weaning success, the optimal NT-proBNP threshold value at the end of the spontaneous breathing trial was <448 ng/l (receiver operating characteristic analysis; sensitivity 68.18%, specificity 85.71%, positive predictive value 93.7% and negative predictive value 46.2%). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Measuring NT-proBNP at the end of a spontaneous breathing trial may assist in predicting weaning success, as a noninvasive, quantitative and repeatable indicator of cardiac stress in patients with postsurgical respiratory failure. </jats:p></jats:sec> N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications Journal of International Medical Research |
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Biologie Chemie und Pharmazie |
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SAGE Publications, 2013 |
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SAGE Publications, 2013 |
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| title |
N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_unstemmed |
N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_full |
N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_fullStr |
N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_full_unstemmed |
N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_short |
N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_sort |
n-terminal prohormone b-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| topic |
Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| url |
http://dx.doi.org/10.1177/0300060513490085 |
| publishDate |
2013 |
| physical |
1612-1621 |
| description |
<jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the relationship between plasma N-terminal prohormone B-type natriuretic peptide (NT-proBNP) and weaning outcomes, and the ability of NT-proBNP level to predict weaning success, in cancer patients with pulmonary complications undergoing noncardiac major surgeries. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Patients who were mechanically ventilated following postoperative respiratory failure were enrolled. NT-proBNP levels at the end of a 2-h spontaneous breathing trial were measured. Weaning was considered a success in patients who completed the trial and maintained spontaneous breathing following extubation for >48 h. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Out of 29 patients, 22 patients weaned successfully but weaning failed in 7 patients. Plasma NT-proBNP was significantly higher in the weaning failure group than in the weaning success group. For predicting weaning success, the optimal NT-proBNP threshold value at the end of the spontaneous breathing trial was <448 ng/l (receiver operating characteristic analysis; sensitivity 68.18%, specificity 85.71%, positive predictive value 93.7% and negative predictive value 46.2%). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Measuring NT-proBNP at the end of a spontaneous breathing trial may assist in predicting weaning success, as a noninvasive, quantitative and repeatable indicator of cardiac stress in patients with postsurgical respiratory failure. </jats:p></jats:sec> |
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| author | Ma, Gang, Liao, Wei, Qiu, Junke, Su, Quanguan, Fang, Yi, Gu, Baochun |
| author_facet | Ma, Gang, Liao, Wei, Qiu, Junke, Su, Quanguan, Fang, Yi, Gu, Baochun, Ma, Gang, Liao, Wei, Qiu, Junke, Su, Quanguan, Fang, Yi, Gu, Baochun |
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| description | <jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the relationship between plasma N-terminal prohormone B-type natriuretic peptide (NT-proBNP) and weaning outcomes, and the ability of NT-proBNP level to predict weaning success, in cancer patients with pulmonary complications undergoing noncardiac major surgeries. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Patients who were mechanically ventilated following postoperative respiratory failure were enrolled. NT-proBNP levels at the end of a 2-h spontaneous breathing trial were measured. Weaning was considered a success in patients who completed the trial and maintained spontaneous breathing following extubation for >48 h. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Out of 29 patients, 22 patients weaned successfully but weaning failed in 7 patients. Plasma NT-proBNP was significantly higher in the weaning failure group than in the weaning success group. For predicting weaning success, the optimal NT-proBNP threshold value at the end of the spontaneous breathing trial was <448 ng/l (receiver operating characteristic analysis; sensitivity 68.18%, specificity 85.71%, positive predictive value 93.7% and negative predictive value 46.2%). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Measuring NT-proBNP at the end of a spontaneous breathing trial may assist in predicting weaning success, as a noninvasive, quantitative and repeatable indicator of cardiac stress in patients with postsurgical respiratory failure. </jats:p></jats:sec> |
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| imprint | SAGE Publications, 2013 |
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| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4 |
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| spelling | Ma, Gang Liao, Wei Qiu, Junke Su, Quanguan Fang, Yi Gu, Baochun 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060513490085 <jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the relationship between plasma N-terminal prohormone B-type natriuretic peptide (NT-proBNP) and weaning outcomes, and the ability of NT-proBNP level to predict weaning success, in cancer patients with pulmonary complications undergoing noncardiac major surgeries. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Patients who were mechanically ventilated following postoperative respiratory failure were enrolled. NT-proBNP levels at the end of a 2-h spontaneous breathing trial were measured. Weaning was considered a success in patients who completed the trial and maintained spontaneous breathing following extubation for >48 h. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Out of 29 patients, 22 patients weaned successfully but weaning failed in 7 patients. Plasma NT-proBNP was significantly higher in the weaning failure group than in the weaning success group. For predicting weaning success, the optimal NT-proBNP threshold value at the end of the spontaneous breathing trial was <448 ng/l (receiver operating characteristic analysis; sensitivity 68.18%, specificity 85.71%, positive predictive value 93.7% and negative predictive value 46.2%). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Measuring NT-proBNP at the end of a spontaneous breathing trial may assist in predicting weaning success, as a noninvasive, quantitative and repeatable indicator of cardiac stress in patients with postsurgical respiratory failure. </jats:p></jats:sec> N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications Journal of International Medical Research |
| spellingShingle | Ma, Gang, Liao, Wei, Qiu, Junke, Su, Quanguan, Fang, Yi, Gu, Baochun, Journal of International Medical Research, N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications, Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| title | N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_full | N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_fullStr | N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_full_unstemmed | N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_short | N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_sort | n-terminal prohormone b-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| title_unstemmed | N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications |
| topic | Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| url | http://dx.doi.org/10.1177/0300060513490085 |