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Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3
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| Zeitschriftentitel: | Journal of International Medical Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Journal of International Medical Research, 47, 2019, 1, S. 159-172 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Stoica, Alexandra Şorodoc, Victoriţa Lionte, Cătălina Jaba, Irina M. Costache, Irina Anisie, Ecaterina Tuchiluș, Cristina Rusalim Petriș, Ovidiu Sîrbu, Oana Jaba, Elisabeta Ceasovschih, Alexandr Vâţă, Luminiţa Şorodoc, Laurenţiu Stoica, Alexandra Şorodoc, Victoriţa Lionte, Cătălina Jaba, Irina M. Costache, Irina Anisie, Ecaterina Tuchiluș, Cristina Rusalim Petriș, Ovidiu Sîrbu, Oana Jaba, Elisabeta Ceasovschih, Alexandr Vâţă, Luminiţa Şorodoc, Laurenţiu |
|---|---|
| author |
Stoica, Alexandra Şorodoc, Victoriţa Lionte, Cătălina Jaba, Irina M. Costache, Irina Anisie, Ecaterina Tuchiluș, Cristina Rusalim Petriș, Ovidiu Sîrbu, Oana Jaba, Elisabeta Ceasovschih, Alexandr Vâţă, Luminiţa Şorodoc, Laurenţiu |
| spellingShingle |
Stoica, Alexandra Şorodoc, Victoriţa Lionte, Cătălina Jaba, Irina M. Costache, Irina Anisie, Ecaterina Tuchiluș, Cristina Rusalim Petriș, Ovidiu Sîrbu, Oana Jaba, Elisabeta Ceasovschih, Alexandr Vâţă, Luminiţa Şorodoc, Laurenţiu Journal of International Medical Research Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| author_sort |
stoica, alexandra |
| spelling |
Stoica, Alexandra Şorodoc, Victoriţa Lionte, Cătălina Jaba, Irina M. Costache, Irina Anisie, Ecaterina Tuchiluș, Cristina Rusalim Petriș, Ovidiu Sîrbu, Oana Jaba, Elisabeta Ceasovschih, Alexandr Vâţă, Luminiţa Şorodoc, Laurenţiu 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060518798257 <jats:sec><jats:title>Objective</jats:title><jats:p>This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission. The patients were divided into two groups according to the etiology of their clinical manifestations: cardiac and non-cardiac dyspnea. The patients’ New York Heart Association functional class, left ventricular ejection fraction, and discharge status were assessed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Diagnostic criteria for acute heart failure were fulfilled in 61.1% of the patients. NT-proBNP and galectin-3 were strongly and significantly correlated. Receiver operating characteristic analysis revealed similar areas under the curve for both markers in the entire group of patients as well as in the high-risk subsets of patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The diagnostic performance of NT-proBNP and galectin-3 is comparable for both the total population and high-risk subsets. Galectin-3 adds diagnostic value to the conventional NT-proBNP in patients with acute cardiac dyspnea, and its utility is of major interest in uncertain clinical situations.</jats:p></jats:sec> Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 Journal of International Medical Research |
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| title |
Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_unstemmed |
Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_full |
Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_fullStr |
Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_full_unstemmed |
Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_short |
Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_sort |
acute cardiac dyspnea in the emergency department: diagnostic value of n-terminal prohormone of brain natriuretic peptide and galectin-3 |
| topic |
Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| url |
http://dx.doi.org/10.1177/0300060518798257 |
| publishDate |
2019 |
| physical |
159-172 |
| description |
<jats:sec><jats:title>Objective</jats:title><jats:p>This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission. The patients were divided into two groups according to the etiology of their clinical manifestations: cardiac and non-cardiac dyspnea. The patients’ New York Heart Association functional class, left ventricular ejection fraction, and discharge status were assessed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Diagnostic criteria for acute heart failure were fulfilled in 61.1% of the patients. NT-proBNP and galectin-3 were strongly and significantly correlated. Receiver operating characteristic analysis revealed similar areas under the curve for both markers in the entire group of patients as well as in the high-risk subsets of patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The diagnostic performance of NT-proBNP and galectin-3 is comparable for both the total population and high-risk subsets. Galectin-3 adds diagnostic value to the conventional NT-proBNP in patients with acute cardiac dyspnea, and its utility is of major interest in uncertain clinical situations.</jats:p></jats:sec> |
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| author | Stoica, Alexandra, Şorodoc, Victoriţa, Lionte, Cătălina, Jaba, Irina M., Costache, Irina, Anisie, Ecaterina, Tuchiluș, Cristina, Rusalim Petriș, Ovidiu, Sîrbu, Oana, Jaba, Elisabeta, Ceasovschih, Alexandr, Vâţă, Luminiţa, Şorodoc, Laurenţiu |
| author_facet | Stoica, Alexandra, Şorodoc, Victoriţa, Lionte, Cătălina, Jaba, Irina M., Costache, Irina, Anisie, Ecaterina, Tuchiluș, Cristina, Rusalim Petriș, Ovidiu, Sîrbu, Oana, Jaba, Elisabeta, Ceasovschih, Alexandr, Vâţă, Luminiţa, Şorodoc, Laurenţiu, Stoica, Alexandra, Şorodoc, Victoriţa, Lionte, Cătălina, Jaba, Irina M., Costache, Irina, Anisie, Ecaterina, Tuchiluș, Cristina, Rusalim Petriș, Ovidiu, Sîrbu, Oana, Jaba, Elisabeta, Ceasovschih, Alexandr, Vâţă, Luminiţa, Şorodoc, Laurenţiu |
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| description | <jats:sec><jats:title>Objective</jats:title><jats:p>This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission. The patients were divided into two groups according to the etiology of their clinical manifestations: cardiac and non-cardiac dyspnea. The patients’ New York Heart Association functional class, left ventricular ejection fraction, and discharge status were assessed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Diagnostic criteria for acute heart failure were fulfilled in 61.1% of the patients. NT-proBNP and galectin-3 were strongly and significantly correlated. Receiver operating characteristic analysis revealed similar areas under the curve for both markers in the entire group of patients as well as in the high-risk subsets of patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The diagnostic performance of NT-proBNP and galectin-3 is comparable for both the total population and high-risk subsets. Galectin-3 adds diagnostic value to the conventional NT-proBNP in patients with acute cardiac dyspnea, and its utility is of major interest in uncertain clinical situations.</jats:p></jats:sec> |
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| spelling | Stoica, Alexandra Şorodoc, Victoriţa Lionte, Cătălina Jaba, Irina M. Costache, Irina Anisie, Ecaterina Tuchiluș, Cristina Rusalim Petriș, Ovidiu Sîrbu, Oana Jaba, Elisabeta Ceasovschih, Alexandr Vâţă, Luminiţa Şorodoc, Laurenţiu 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060518798257 <jats:sec><jats:title>Objective</jats:title><jats:p>This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission. The patients were divided into two groups according to the etiology of their clinical manifestations: cardiac and non-cardiac dyspnea. The patients’ New York Heart Association functional class, left ventricular ejection fraction, and discharge status were assessed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Diagnostic criteria for acute heart failure were fulfilled in 61.1% of the patients. NT-proBNP and galectin-3 were strongly and significantly correlated. Receiver operating characteristic analysis revealed similar areas under the curve for both markers in the entire group of patients as well as in the high-risk subsets of patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The diagnostic performance of NT-proBNP and galectin-3 is comparable for both the total population and high-risk subsets. Galectin-3 adds diagnostic value to the conventional NT-proBNP in patients with acute cardiac dyspnea, and its utility is of major interest in uncertain clinical situations.</jats:p></jats:sec> Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 Journal of International Medical Research |
| spellingShingle | Stoica, Alexandra, Şorodoc, Victoriţa, Lionte, Cătălina, Jaba, Irina M., Costache, Irina, Anisie, Ecaterina, Tuchiluș, Cristina, Rusalim Petriș, Ovidiu, Sîrbu, Oana, Jaba, Elisabeta, Ceasovschih, Alexandr, Vâţă, Luminiţa, Şorodoc, Laurenţiu, Journal of International Medical Research, Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3, Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| title | Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_full | Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_fullStr | Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_full_unstemmed | Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_short | Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_sort | acute cardiac dyspnea in the emergency department: diagnostic value of n-terminal prohormone of brain natriuretic peptide and galectin-3 |
| title_unstemmed | Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3 |
| topic | Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| url | http://dx.doi.org/10.1177/0300060518798257 |