Eintrag weiter verarbeiten
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis
Gespeichert in:
Zeitschriftentitel: | Journal of International Medical Research |
---|---|
Personen und Körperschaften: | , , , , , , , |
In: | Journal of International Medical Research, 46, 2018, 6, S. 2398-2409 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
SAGE Publications
|
Schlagwörter: |
author_facet |
Wang, Yi Hu, Ying Ma, Ben Wang, Fei Liu, Sheng Xu, Jing Chen, Xu-Lin Lü, Xiong-Wen Wang, Yi Hu, Ying Ma, Ben Wang, Fei Liu, Sheng Xu, Jing Chen, Xu-Lin Lü, Xiong-Wen |
---|---|
author |
Wang, Yi Hu, Ying Ma, Ben Wang, Fei Liu, Sheng Xu, Jing Chen, Xu-Lin Lü, Xiong-Wen |
spellingShingle |
Wang, Yi Hu, Ying Ma, Ben Wang, Fei Liu, Sheng Xu, Jing Chen, Xu-Lin Lü, Xiong-Wen Journal of International Medical Research Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis Biochemistry (medical) Cell Biology Biochemistry General Medicine |
author_sort |
wang, yi |
spelling |
Wang, Yi Hu, Ying Ma, Ben Wang, Fei Liu, Sheng Xu, Jing Chen, Xu-Lin Lü, Xiong-Wen 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060518764210 <jats:sec><jats:title>Objective</jats:title><jats:p> This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses. The expression levels of CD31, CD68, and F4/80 in the tissues were examined immunohistologically. The expression of transforming growth factor (TGF)-β1 in the wound was determined by western blot. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> N-CWS increased the wound healing rate, reduced the complete wound healing time, and increased the expression levels of CD31, CD68, and F4/80 on day 7. The TGF-β1 expression level in the wound was significantly higher in the N-CWS group than in the control group on day 7. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> N-CWS can activate macrophages, increase TGF-β1 expression, and enhance angiogenesis and thus accelerate cutaneous wound healing. </jats:p></jats:sec> <i>Nocardia rubra</i> cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis Journal of International Medical Research |
doi_str_mv |
10.1177/0300060518764210 |
facet_avail |
Online Free |
finc_class_facet |
Biologie Chemie und Pharmazie |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8wMzAwMDYwNTE4NzY0MjEw |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8wMzAwMDYwNTE4NzY0MjEw |
institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 |
imprint |
SAGE Publications, 2018 |
imprint_str_mv |
SAGE Publications, 2018 |
issn |
1473-2300 0300-0605 |
issn_str_mv |
1473-2300 0300-0605 |
language |
English |
mega_collection |
SAGE Publications (CrossRef) |
match_str |
wang2018nocardiarubracellwallskeletonacceleratescutaneouswoundhealingbyenhancingmacrophageactivationandangiogenesis |
publishDateSort |
2018 |
publisher |
SAGE Publications |
recordtype |
ai |
record_format |
ai |
series |
Journal of International Medical Research |
source_id |
49 |
title |
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_unstemmed |
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_full |
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_fullStr |
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_full_unstemmed |
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_short |
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_sort |
<i>nocardia rubra</i> cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
topic |
Biochemistry (medical) Cell Biology Biochemistry General Medicine |
url |
http://dx.doi.org/10.1177/0300060518764210 |
publishDate |
2018 |
physical |
2398-2409 |
description |
<jats:sec><jats:title>Objective</jats:title><jats:p> This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses. The expression levels of CD31, CD68, and F4/80 in the tissues were examined immunohistologically. The expression of transforming growth factor (TGF)-β1 in the wound was determined by western blot. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> N-CWS increased the wound healing rate, reduced the complete wound healing time, and increased the expression levels of CD31, CD68, and F4/80 on day 7. The TGF-β1 expression level in the wound was significantly higher in the N-CWS group than in the control group on day 7. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> N-CWS can activate macrophages, increase TGF-β1 expression, and enhance angiogenesis and thus accelerate cutaneous wound healing. </jats:p></jats:sec> |
container_issue |
6 |
container_start_page |
2398 |
container_title |
Journal of International Medical Research |
container_volume |
46 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792340698451673097 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T16:08:09.264Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Nocardia+rubra+cell+wall+skeleton+accelerates+cutaneous+wound+healing+by+enhancing+macrophage+activation+and+angiogenesis&rft.date=2018-06-01&genre=article&issn=1473-2300&volume=46&issue=6&spage=2398&epage=2409&pages=2398-2409&jtitle=Journal+of+International+Medical+Research&atitle=%3Ci%3ENocardia+rubra%3C%2Fi%3E+cell+wall+skeleton+accelerates+cutaneous+wound+healing+by+enhancing+macrophage+activation+and+angiogenesis&aulast=L%C3%BC&aufirst=Xiong-Wen&rft_id=info%3Adoi%2F10.1177%2F0300060518764210&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792340698451673097 |
author | Wang, Yi, Hu, Ying, Ma, Ben, Wang, Fei, Liu, Sheng, Xu, Jing, Chen, Xu-Lin, Lü, Xiong-Wen |
author_facet | Wang, Yi, Hu, Ying, Ma, Ben, Wang, Fei, Liu, Sheng, Xu, Jing, Chen, Xu-Lin, Lü, Xiong-Wen, Wang, Yi, Hu, Ying, Ma, Ben, Wang, Fei, Liu, Sheng, Xu, Jing, Chen, Xu-Lin, Lü, Xiong-Wen |
author_sort | wang, yi |
container_issue | 6 |
container_start_page | 2398 |
container_title | Journal of International Medical Research |
container_volume | 46 |
description | <jats:sec><jats:title>Objective</jats:title><jats:p> This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses. The expression levels of CD31, CD68, and F4/80 in the tissues were examined immunohistologically. The expression of transforming growth factor (TGF)-β1 in the wound was determined by western blot. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> N-CWS increased the wound healing rate, reduced the complete wound healing time, and increased the expression levels of CD31, CD68, and F4/80 on day 7. The TGF-β1 expression level in the wound was significantly higher in the N-CWS group than in the control group on day 7. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> N-CWS can activate macrophages, increase TGF-β1 expression, and enhance angiogenesis and thus accelerate cutaneous wound healing. </jats:p></jats:sec> |
doi_str_mv | 10.1177/0300060518764210 |
facet_avail | Online, Free |
finc_class_facet | Biologie, Chemie und Pharmazie |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE3Ny8wMzAwMDYwNTE4NzY0MjEw |
imprint | SAGE Publications, 2018 |
imprint_str_mv | SAGE Publications, 2018 |
institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
issn | 1473-2300, 0300-0605 |
issn_str_mv | 1473-2300, 0300-0605 |
language | English |
last_indexed | 2024-03-01T16:08:09.264Z |
match_str | wang2018nocardiarubracellwallskeletonacceleratescutaneouswoundhealingbyenhancingmacrophageactivationandangiogenesis |
mega_collection | SAGE Publications (CrossRef) |
physical | 2398-2409 |
publishDate | 2018 |
publishDateSort | 2018 |
publisher | SAGE Publications |
record_format | ai |
recordtype | ai |
series | Journal of International Medical Research |
source_id | 49 |
spelling | Wang, Yi Hu, Ying Ma, Ben Wang, Fei Liu, Sheng Xu, Jing Chen, Xu-Lin Lü, Xiong-Wen 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060518764210 <jats:sec><jats:title>Objective</jats:title><jats:p> This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses. The expression levels of CD31, CD68, and F4/80 in the tissues were examined immunohistologically. The expression of transforming growth factor (TGF)-β1 in the wound was determined by western blot. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> N-CWS increased the wound healing rate, reduced the complete wound healing time, and increased the expression levels of CD31, CD68, and F4/80 on day 7. The TGF-β1 expression level in the wound was significantly higher in the N-CWS group than in the control group on day 7. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> N-CWS can activate macrophages, increase TGF-β1 expression, and enhance angiogenesis and thus accelerate cutaneous wound healing. </jats:p></jats:sec> <i>Nocardia rubra</i> cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis Journal of International Medical Research |
spellingShingle | Wang, Yi, Hu, Ying, Ma, Ben, Wang, Fei, Liu, Sheng, Xu, Jing, Chen, Xu-Lin, Lü, Xiong-Wen, Journal of International Medical Research, Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis, Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
title | Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_full | Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_fullStr | Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_full_unstemmed | Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_short | Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_sort | <i>nocardia rubra</i> cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
title_unstemmed | Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis |
topic | Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
url | http://dx.doi.org/10.1177/0300060518764210 |