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Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placeb...
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| Zeitschriftentitel: | Journal of International Medical Research |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Journal of International Medical Research, 46, 2018, 3, S. 1063-1072 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Wang, Wei Yu, Wan-You Lv, Jie Chen, Lian-Hua Li, Zhong Wang, Wei Yu, Wan-You Lv, Jie Chen, Lian-Hua Li, Zhong |
|---|---|
| author |
Wang, Wei Yu, Wan-You Lv, Jie Chen, Lian-Hua Li, Zhong |
| spellingShingle |
Wang, Wei Yu, Wan-You Lv, Jie Chen, Lian-Hua Li, Zhong Journal of International Medical Research Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| author_sort |
wang, wei |
| spelling |
Wang, Wei Yu, Wan-You Lv, Jie Chen, Lian-Hua Li, Zhong 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060517744957 <jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T<jats:sub>0</jats:sub>), skin incision (T<jats:sub>1</jats:sub>), cutting the gallbladder (T<jats:sub>2</jats:sub>), suturing the peritoneum (T<jats:sub>3</jats:sub>), skin closure (T<jats:sub>4</jats:sub>), sputum suction (T<jats:sub>5</jats:sub>), extubation (T<jats:sub>6</jats:sub>) and 1 min (T<jats:sub>7</jats:sub>), 5 min (T<jats:sub>8</jats:sub>), 10 min (T<jats:sub>9</jats:sub>), and 15 min (T<jats:sub>10</jats:sub>) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T<jats:sub>7</jats:sub>, T<jats:sub>8</jats:sub>, T<jats:sub>9</jats:sub> and T<jats:sub>10</jats:sub> were recorded. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T<jats:sub>5</jats:sub>, T<jats:sub>6</jats:sub>, T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub>; and the Steward recovery scores at T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub> were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Creatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients. </jats:p></jats:sec> Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial Journal of International Medical Research |
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| title |
Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_unstemmed |
Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_full |
Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_fullStr |
Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed |
Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_short |
Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_sort |
effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: a randomized, double-blind, placebo-controlled trial |
| topic |
Biochemistry (medical) Cell Biology Biochemistry General Medicine |
| url |
http://dx.doi.org/10.1177/0300060517744957 |
| publishDate |
2018 |
| physical |
1063-1072 |
| description |
<jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T<jats:sub>0</jats:sub>), skin incision (T<jats:sub>1</jats:sub>), cutting the gallbladder (T<jats:sub>2</jats:sub>), suturing the peritoneum (T<jats:sub>3</jats:sub>), skin closure (T<jats:sub>4</jats:sub>), sputum suction (T<jats:sub>5</jats:sub>), extubation (T<jats:sub>6</jats:sub>) and 1 min (T<jats:sub>7</jats:sub>), 5 min (T<jats:sub>8</jats:sub>), 10 min (T<jats:sub>9</jats:sub>), and 15 min (T<jats:sub>10</jats:sub>) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T<jats:sub>7</jats:sub>, T<jats:sub>8</jats:sub>, T<jats:sub>9</jats:sub> and T<jats:sub>10</jats:sub> were recorded. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T<jats:sub>5</jats:sub>, T<jats:sub>6</jats:sub>, T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub>; and the Steward recovery scores at T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub> were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Creatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients. </jats:p></jats:sec> |
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| author | Wang, Wei, Yu, Wan-You, Lv, Jie, Chen, Lian-Hua, Li, Zhong |
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| description | <jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T<jats:sub>0</jats:sub>), skin incision (T<jats:sub>1</jats:sub>), cutting the gallbladder (T<jats:sub>2</jats:sub>), suturing the peritoneum (T<jats:sub>3</jats:sub>), skin closure (T<jats:sub>4</jats:sub>), sputum suction (T<jats:sub>5</jats:sub>), extubation (T<jats:sub>6</jats:sub>) and 1 min (T<jats:sub>7</jats:sub>), 5 min (T<jats:sub>8</jats:sub>), 10 min (T<jats:sub>9</jats:sub>), and 15 min (T<jats:sub>10</jats:sub>) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T<jats:sub>7</jats:sub>, T<jats:sub>8</jats:sub>, T<jats:sub>9</jats:sub> and T<jats:sub>10</jats:sub> were recorded. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T<jats:sub>5</jats:sub>, T<jats:sub>6</jats:sub>, T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub>; and the Steward recovery scores at T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub> were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Creatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients. </jats:p></jats:sec> |
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| spelling | Wang, Wei Yu, Wan-You Lv, Jie Chen, Lian-Hua Li, Zhong 0300-0605 1473-2300 SAGE Publications Biochemistry (medical) Cell Biology Biochemistry General Medicine http://dx.doi.org/10.1177/0300060517744957 <jats:sec><jats:title>Objective</jats:title><jats:p> To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T<jats:sub>0</jats:sub>), skin incision (T<jats:sub>1</jats:sub>), cutting the gallbladder (T<jats:sub>2</jats:sub>), suturing the peritoneum (T<jats:sub>3</jats:sub>), skin closure (T<jats:sub>4</jats:sub>), sputum suction (T<jats:sub>5</jats:sub>), extubation (T<jats:sub>6</jats:sub>) and 1 min (T<jats:sub>7</jats:sub>), 5 min (T<jats:sub>8</jats:sub>), 10 min (T<jats:sub>9</jats:sub>), and 15 min (T<jats:sub>10</jats:sub>) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T<jats:sub>7</jats:sub>, T<jats:sub>8</jats:sub>, T<jats:sub>9</jats:sub> and T<jats:sub>10</jats:sub> were recorded. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T<jats:sub>5</jats:sub>, T<jats:sub>6</jats:sub>, T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub>; and the Steward recovery scores at T<jats:sub>7</jats:sub> and T<jats:sub>8</jats:sub> were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Creatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients. </jats:p></jats:sec> Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial Journal of International Medical Research |
| spellingShingle | Wang, Wei, Yu, Wan-You, Lv, Jie, Chen, Lian-Hua, Li, Zhong, Journal of International Medical Research, Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial, Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| title | Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_full | Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_fullStr | Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_short | Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| title_sort | effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: a randomized, double-blind, placebo-controlled trial |
| title_unstemmed | Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial |
| topic | Biochemistry (medical), Cell Biology, Biochemistry, General Medicine |
| url | http://dx.doi.org/10.1177/0300060517744957 |