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Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue
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| Zeitschriftentitel: | Journal of Cerebral Blood Flow & Metabolism |
|---|---|
| Personen und Körperschaften: | |
| In: | Journal of Cerebral Blood Flow & Metabolism, 36, 2016, 3, S. 639-644 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
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Feuerstein, Giora Z Feuerstein, Giora Z |
|---|---|
| author |
Feuerstein, Giora Z |
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Feuerstein, Giora Z Journal of Cerebral Blood Flow & Metabolism Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
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feuerstein, giora z |
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Feuerstein, Giora Z 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1177/0271678x15619429 <jats:p> Pharmacological tools (compounds) have an important role in validation of biological molecular targets for their role in disease processes and their prospective development for therapeutic objectives. Effective utilization of such pharmacological tools impacts on the veracity of the information by which decisions regarding target validation is reached, and investment in clinical development is committed. This commentary addresses frequent gaps in effective utilization of pharmacological principles and practices of pharmacokinetics and pharmacodynamics in experimental pre-clinical research, which if more rigorously implemented could contribute to eventual success in drug development for stroke and neurotrauma. </jats:p> Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue Journal of Cerebral Blood Flow & Metabolism |
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Journal of Cerebral Blood Flow & Metabolism |
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Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
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Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
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Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
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Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
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Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
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Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
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pharmacology in cerebrovascular disease research: pharmacokinetics–pharmacodynamics to the rescue |
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Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
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http://dx.doi.org/10.1177/0271678x15619429 |
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2016 |
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<jats:p> Pharmacological tools (compounds) have an important role in validation of biological molecular targets for their role in disease processes and their prospective development for therapeutic objectives. Effective utilization of such pharmacological tools impacts on the veracity of the information by which decisions regarding target validation is reached, and investment in clinical development is committed. This commentary addresses frequent gaps in effective utilization of pharmacological principles and practices of pharmacokinetics and pharmacodynamics in experimental pre-clinical research, which if more rigorously implemented could contribute to eventual success in drug development for stroke and neurotrauma. </jats:p> |
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| description | <jats:p> Pharmacological tools (compounds) have an important role in validation of biological molecular targets for their role in disease processes and their prospective development for therapeutic objectives. Effective utilization of such pharmacological tools impacts on the veracity of the information by which decisions regarding target validation is reached, and investment in clinical development is committed. This commentary addresses frequent gaps in effective utilization of pharmacological principles and practices of pharmacokinetics and pharmacodynamics in experimental pre-clinical research, which if more rigorously implemented could contribute to eventual success in drug development for stroke and neurotrauma. </jats:p> |
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| spelling | Feuerstein, Giora Z 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1177/0271678x15619429 <jats:p> Pharmacological tools (compounds) have an important role in validation of biological molecular targets for their role in disease processes and their prospective development for therapeutic objectives. Effective utilization of such pharmacological tools impacts on the veracity of the information by which decisions regarding target validation is reached, and investment in clinical development is committed. This commentary addresses frequent gaps in effective utilization of pharmacological principles and practices of pharmacokinetics and pharmacodynamics in experimental pre-clinical research, which if more rigorously implemented could contribute to eventual success in drug development for stroke and neurotrauma. </jats:p> Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue Journal of Cerebral Blood Flow & Metabolism |
| spellingShingle | Feuerstein, Giora Z, Journal of Cerebral Blood Flow & Metabolism, Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue, Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| title | Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
| title_full | Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
| title_fullStr | Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
| title_full_unstemmed | Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
| title_short | Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
| title_sort | pharmacology in cerebrovascular disease research: pharmacokinetics–pharmacodynamics to the rescue |
| title_unstemmed | Pharmacology in cerebrovascular disease research: Pharmacokinetics–pharmacodynamics to the rescue |
| topic | Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| url | http://dx.doi.org/10.1177/0271678x15619429 |