Eintrag weiter verarbeiten
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke
Gespeichert in:
| Zeitschriftentitel: | Stroke |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Stroke, 44, 2013, 8, S. 2134-2138 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Rocco, Andrea Heuschmann, Peter U. Schellinger, Peter D. Köhrmann, Martin Diedler, Jennifer Sykora, Marek Nolte, Christian H. Ringleb, Peter Hacke, Werner Jüttler, Eric Rocco, Andrea Heuschmann, Peter U. Schellinger, Peter D. Köhrmann, Martin Diedler, Jennifer Sykora, Marek Nolte, Christian H. Ringleb, Peter Hacke, Werner Jüttler, Eric |
|---|---|
| author |
Rocco, Andrea Heuschmann, Peter U. Schellinger, Peter D. Köhrmann, Martin Diedler, Jennifer Sykora, Marek Nolte, Christian H. Ringleb, Peter Hacke, Werner Jüttler, Eric |
| spellingShingle |
Rocco, Andrea Heuschmann, Peter U. Schellinger, Peter D. Köhrmann, Martin Diedler, Jennifer Sykora, Marek Nolte, Christian H. Ringleb, Peter Hacke, Werner Jüttler, Eric Stroke Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| author_sort |
rocco, andrea |
| spelling |
Rocco, Andrea Heuschmann, Peter U. Schellinger, Peter D. Köhrmann, Martin Diedler, Jennifer Sykora, Marek Nolte, Christian H. Ringleb, Peter Hacke, Werner Jüttler, Eric 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/strokeaha.111.675918 <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p> Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of parameters of glycosylated hemoglobin A1 (HbA <jats:sub>1c</jats:sub> ) on sICH. </jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose was obtained at admission. HbA <jats:sub>1c</jats:sub> was determined within hospital stay. A second head computed tomography was obtained after 24 hours or when neurological worsening occurred. Modified Rankin Scale was used to assess outcome at 90 days. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> A total of 222 patients (19.9%) had any hemorrhage; 43 of those had sICH (3.9%) per Safe Implementation of Treatments in Stroke definition and 95 (8.5%) per National Institute of Neurological Disorders and Stroke definition; 33.2% of patients had a dependent outcome (modified Rankin Scale score 3–5). In univariate analysis history of diabetes mellitus, HbA <jats:sub>1c</jats:sub> , blood glucose, and National Institute of Health Stroke Scale score on admission were associated with any hemorrhage and sICH. In multivariate analysis National Institute of Health Stroke Scale score, a history of diabetes mellitus, and HbA <jats:sub>1c</jats:sub> were predictors of sICH per National Institute of Neurological Disorders and Stroke, and only HbA <jats:sub>1c</jats:sub> when Safe Implementation of Treatments in Stroke criteria were used. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> In our study, HbA <jats:sub>1c</jats:sub> turns out to be an important predictor of sICH after thrombolysis for acute stroke. These results suggest that hemorrhage after thrombolysis may be a consequence of long-term vascular injury rather than of acute hyperglycemia, and that HbA <jats:sub>1c</jats:sub> may be a better predictor than acute blood glucose or a history of diabetes mellitus. </jats:p> </jats:sec> Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke Stroke |
| doi_str_mv |
10.1161/strokeaha.111.675918 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS9zdHJva2VhaGEuMTExLjY3NTkxOA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS9zdHJva2VhaGEuMTExLjY3NTkxOA |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Ovid Technologies (Wolters Kluwer Health), 2013 |
| imprint_str_mv |
Ovid Technologies (Wolters Kluwer Health), 2013 |
| issn |
0039-2499 1524-4628 |
| issn_str_mv |
0039-2499 1524-4628 |
| language |
English |
| mega_collection |
Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| match_str |
rocco2013glycosylatedhemoglobina1predictsriskforsymptomatichemorrhageafterthrombolysisforacutestroke |
| publishDateSort |
2013 |
| publisher |
Ovid Technologies (Wolters Kluwer Health) |
| recordtype |
ai |
| record_format |
ai |
| series |
Stroke |
| source_id |
49 |
| title |
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_unstemmed |
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_full |
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_fullStr |
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_full_unstemmed |
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_short |
Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_sort |
glycosylated hemoglobin a1 predicts risk for symptomatic hemorrhage after thrombolysis for acute stroke |
| topic |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| url |
http://dx.doi.org/10.1161/strokeaha.111.675918 |
| publishDate |
2013 |
| physical |
2134-2138 |
| description |
<jats:sec>
<jats:title>Background and Purpose—</jats:title>
<jats:p>
Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of parameters of glycosylated hemoglobin A1 (HbA
<jats:sub>1c</jats:sub>
) on sICH.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods—</jats:title>
<jats:p>
In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose was obtained at admission. HbA
<jats:sub>1c</jats:sub>
was determined within hospital stay. A second head computed tomography was obtained after 24 hours or when neurological worsening occurred. Modified Rankin Scale was used to assess outcome at 90 days.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results—</jats:title>
<jats:p>
A total of 222 patients (19.9%) had any hemorrhage; 43 of those had sICH (3.9%) per Safe Implementation of Treatments in Stroke definition and 95 (8.5%) per National Institute of Neurological Disorders and Stroke definition; 33.2% of patients had a dependent outcome (modified Rankin Scale score 3–5). In univariate analysis history of diabetes mellitus, HbA
<jats:sub>1c</jats:sub>
, blood glucose, and National Institute of Health Stroke Scale score on admission were associated with any hemorrhage and sICH. In multivariate analysis National Institute of Health Stroke Scale score, a history of diabetes mellitus, and HbA
<jats:sub>1c</jats:sub>
were predictors of sICH per National Institute of Neurological Disorders and Stroke, and only HbA
<jats:sub>1c</jats:sub>
when Safe Implementation of Treatments in Stroke criteria were used.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions—</jats:title>
<jats:p>
In our study, HbA
<jats:sub>1c</jats:sub>
turns out to be an important predictor of sICH after thrombolysis for acute stroke. These results suggest that hemorrhage after thrombolysis may be a consequence of long-term vascular injury rather than of acute hyperglycemia, and that HbA
<jats:sub>1c</jats:sub>
may be a better predictor than acute blood glucose or a history of diabetes mellitus.
</jats:p>
</jats:sec> |
| container_issue |
8 |
| container_start_page |
2134 |
| container_title |
Stroke |
| container_volume |
44 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792334838112452614 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:34:58.939Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Glycosylated+Hemoglobin+A1+Predicts+Risk+for+Symptomatic+Hemorrhage+After+Thrombolysis+for+Acute+Stroke&rft.date=2013-08-01&genre=article&issn=1524-4628&volume=44&issue=8&spage=2134&epage=2138&pages=2134-2138&jtitle=Stroke&atitle=Glycosylated+Hemoglobin+A1+Predicts+Risk+for+Symptomatic+Hemorrhage+After+Thrombolysis+for+Acute+Stroke&aulast=J%C3%BCttler&aufirst=Eric&rft_id=info%3Adoi%2F10.1161%2Fstrokeaha.111.675918&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792334838112452614 |
| author | Rocco, Andrea, Heuschmann, Peter U., Schellinger, Peter D., Köhrmann, Martin, Diedler, Jennifer, Sykora, Marek, Nolte, Christian H., Ringleb, Peter, Hacke, Werner, Jüttler, Eric |
| author_facet | Rocco, Andrea, Heuschmann, Peter U., Schellinger, Peter D., Köhrmann, Martin, Diedler, Jennifer, Sykora, Marek, Nolte, Christian H., Ringleb, Peter, Hacke, Werner, Jüttler, Eric, Rocco, Andrea, Heuschmann, Peter U., Schellinger, Peter D., Köhrmann, Martin, Diedler, Jennifer, Sykora, Marek, Nolte, Christian H., Ringleb, Peter, Hacke, Werner, Jüttler, Eric |
| author_sort | rocco, andrea |
| container_issue | 8 |
| container_start_page | 2134 |
| container_title | Stroke |
| container_volume | 44 |
| description | <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p> Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of parameters of glycosylated hemoglobin A1 (HbA <jats:sub>1c</jats:sub> ) on sICH. </jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose was obtained at admission. HbA <jats:sub>1c</jats:sub> was determined within hospital stay. A second head computed tomography was obtained after 24 hours or when neurological worsening occurred. Modified Rankin Scale was used to assess outcome at 90 days. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> A total of 222 patients (19.9%) had any hemorrhage; 43 of those had sICH (3.9%) per Safe Implementation of Treatments in Stroke definition and 95 (8.5%) per National Institute of Neurological Disorders and Stroke definition; 33.2% of patients had a dependent outcome (modified Rankin Scale score 3–5). In univariate analysis history of diabetes mellitus, HbA <jats:sub>1c</jats:sub> , blood glucose, and National Institute of Health Stroke Scale score on admission were associated with any hemorrhage and sICH. In multivariate analysis National Institute of Health Stroke Scale score, a history of diabetes mellitus, and HbA <jats:sub>1c</jats:sub> were predictors of sICH per National Institute of Neurological Disorders and Stroke, and only HbA <jats:sub>1c</jats:sub> when Safe Implementation of Treatments in Stroke criteria were used. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> In our study, HbA <jats:sub>1c</jats:sub> turns out to be an important predictor of sICH after thrombolysis for acute stroke. These results suggest that hemorrhage after thrombolysis may be a consequence of long-term vascular injury rather than of acute hyperglycemia, and that HbA <jats:sub>1c</jats:sub> may be a better predictor than acute blood glucose or a history of diabetes mellitus. </jats:p> </jats:sec> |
| doi_str_mv | 10.1161/strokeaha.111.675918 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2MS9zdHJva2VhaGEuMTExLjY3NTkxOA |
| imprint | Ovid Technologies (Wolters Kluwer Health), 2013 |
| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2013 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0039-2499, 1524-4628 |
| issn_str_mv | 0039-2499, 1524-4628 |
| language | English |
| last_indexed | 2024-03-01T14:34:58.939Z |
| match_str | rocco2013glycosylatedhemoglobina1predictsriskforsymptomatichemorrhageafterthrombolysisforacutestroke |
| mega_collection | Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| physical | 2134-2138 |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | ai |
| recordtype | ai |
| series | Stroke |
| source_id | 49 |
| spelling | Rocco, Andrea Heuschmann, Peter U. Schellinger, Peter D. Köhrmann, Martin Diedler, Jennifer Sykora, Marek Nolte, Christian H. Ringleb, Peter Hacke, Werner Jüttler, Eric 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/strokeaha.111.675918 <jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p> Symptomatic intracerebral hemorrhage (sICH) is the most feared acute complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of parameters of glycosylated hemoglobin A1 (HbA <jats:sub>1c</jats:sub> ) on sICH. </jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> In a retrospective single center series, 1112 consecutive patients treated with thrombolysis were studied. Baseline blood glucose was obtained at admission. HbA <jats:sub>1c</jats:sub> was determined within hospital stay. A second head computed tomography was obtained after 24 hours or when neurological worsening occurred. Modified Rankin Scale was used to assess outcome at 90 days. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> A total of 222 patients (19.9%) had any hemorrhage; 43 of those had sICH (3.9%) per Safe Implementation of Treatments in Stroke definition and 95 (8.5%) per National Institute of Neurological Disorders and Stroke definition; 33.2% of patients had a dependent outcome (modified Rankin Scale score 3–5). In univariate analysis history of diabetes mellitus, HbA <jats:sub>1c</jats:sub> , blood glucose, and National Institute of Health Stroke Scale score on admission were associated with any hemorrhage and sICH. In multivariate analysis National Institute of Health Stroke Scale score, a history of diabetes mellitus, and HbA <jats:sub>1c</jats:sub> were predictors of sICH per National Institute of Neurological Disorders and Stroke, and only HbA <jats:sub>1c</jats:sub> when Safe Implementation of Treatments in Stroke criteria were used. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p> In our study, HbA <jats:sub>1c</jats:sub> turns out to be an important predictor of sICH after thrombolysis for acute stroke. These results suggest that hemorrhage after thrombolysis may be a consequence of long-term vascular injury rather than of acute hyperglycemia, and that HbA <jats:sub>1c</jats:sub> may be a better predictor than acute blood glucose or a history of diabetes mellitus. </jats:p> </jats:sec> Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke Stroke |
| spellingShingle | Rocco, Andrea, Heuschmann, Peter U., Schellinger, Peter D., Köhrmann, Martin, Diedler, Jennifer, Sykora, Marek, Nolte, Christian H., Ringleb, Peter, Hacke, Werner, Jüttler, Eric, Stroke, Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke, Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| title | Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_full | Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_fullStr | Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_full_unstemmed | Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_short | Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| title_sort | glycosylated hemoglobin a1 predicts risk for symptomatic hemorrhage after thrombolysis for acute stroke |
| title_unstemmed | Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke |
| topic | Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| url | http://dx.doi.org/10.1161/strokeaha.111.675918 |